Showing 76–100 of 200 documents
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Qi X, Yang Q, Cai J, Wu J, Gao Y, et al.
Household contacts (HHCs) of patients with active tuberculosis (ATB) are at higher risk of Mycobacterium tuberculosis ( M. tuberculosis ) infection. However, the immune factors responsible for different defense responses in HHCs are unknown. Hence, we aimed to evaluate transcript…
Owusu W, van Vliet AHM, Riddell NE, Stewart G, Akwani WC, et al.
In low-resource settings with high tuberculosis (TB) burdens, lack of rapid diagnostic methods for detection and differentiation of Mycobacterium tuberculosis complex (MTBC) is a major challenge affecting TB management. This study utilized comparative genomic analyses of MTBC lin…
Chen L, Yuan L, Sun T, Liu R, Huang Q, et al.
Background Tuberculosis is a chronic infectious disease caused by mycobacterium tuberculosis (MTB) and is the ninth leading cause of death worldwide. It is still difficult to distinguish active TB from latent TB,but it is very important for individualized management and treatment…
Carvalho I, Goletti D, Manga S, Silva DR, Manissero D, et al.
Tuberculosis (TB) is a major cause of childhood morbidity and mortality worldwide. The aim of this review is to describe the management of the child with TB and latent tuberculosis infection (LTBI). To develop this article, a working group reviewed relevant epidemiological and ot…
Barbara E de Bary, Marlies Heudobler, Alois Fürst, Kirsten Utpatel, Elisabeth Schuierer, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a significant global health issue, with extrapulmonary manifestations accounting for a notable proportion of cases. Perianal tuberculosis, however, is a rare presentation of TB, often leading to delayed diagnosis due to its nonspecific …
Lu P, Xu J, Wang R, Gong X, Liu Q, et al.
… is recommended by the World Health Organization for latent tuberculosis infection (LTBI). However, it is still unknown how the EC skin test performs in students during a school tuberculosis outbreak. Methods We conducted an epidemiological investigation to assess the performance…
Flynn AG, Aiona K, Haas MK, Reves R, Belknap R
Although rare, subclinical tuberculosis disease can be missed during evaluations for latent tuberculosis infection, and can manifest with symptoms during latent tuberculosis treatment. Among over 8000 patients treated for latent tuberculosis we found no evidence of acquired drug …
Della Bella C, Spinicci M, Grassi A, Bartalesi F, Benagiano M, et al.
Background Tuberculosis (TB) still is a major worldwide health problem, with 10.4 million new cases in 2016. Only 5-15% of people infected with M. tuberculosis develop TB disease while others remain latently infected (LTBI) during their lifetime. Thus, the absence of tests able t…
Ye L, Cao Y, Fu Y, Tian C, Cao Q
Background Discriminating Crohn's disease (CD) with latent tuberculosis infection (LTBI) from intestinal tuberculosis (ITB) in tuberculosis-endemic regions remains challenging. Aim To assess whether targeted next-generation sequencing (tNGS) could be an efficient method for ITB d…
Smith A, Kempker R, Wassie L, Bobosha K, Nizam A, et al.
…amines the association between diabetes mellitus and latent tuberculosis infection among a cohort of household contacts exposed to active tuberculosis in Ethiopia, focusing attention on the need for further translational research to determine the mechanisms of susceptibility to M…
Liu Y, Zhang L, Chen Y, Ruan G, Liu Y, et al.
Background The population with latent tuberculosis infection (LTBI) represents a potential pool of patients with active tuberculosis (ATB). T-SPOT.TB is an important test tool for screening LTBI. Owing to the large population of LTBI patients in China, it is necessary to identify…
Luo D, Yang BY, Qin K, Shi CY, Wei NS, et al.
Purpose Distinguishing latent tuberculosis infection (LTBI) from active tuberculosis (ATB) is important to control the prevalence of tuberculosis; however, there is currently no effective method. The aim of this study was to discover specific metabolites through fecal untargeted …
Justen T Despain, John L Kiley, Mary B Ford
**INTRODUCTION:** Tuberculosis (TB) causes significant morbidity and mortality worldwide. Diagnosing TB in service members can be a challenge given the overall low incidence but increased risk of exposure that accompanies military travel, training and activities. Here we describe…
Tang W, Leonhardt L, Pervez A, Sarvepalli S
The reactivation of latent tuberculosis occurs when a patient living with Mycobacterium tuberculosis enters a state where the immune system is suppressed. Since early 2021, the standard of care has been to provide corticosteroids in patients with COVID-19 infection in hospitalize…
Lee JY, Kim BJ, Koo HK, Kim J, Kim JM, et al.
Tuberculosis remains a major public health problem. Conventional tests are inadequate to distinguish between active tuberculosis (ATB) and latent tuberculosis infection (LTBI). We measured antibody responses to Mycobacterium tuberculosis antigens ( Mycobacterium tuberculosis chor…
Revadi G, Johann Aibantyllilang Blah, Manoj Verma, Arun M Kokane
**INTRODUCTION:** Latent Tuberculosis infection (LTBI) care cascade involves identification of high-risk individuals, testing, identification of LTBI, initiation of Tuberculosis Preventive therapy (TPT) and documentation of outcomes. There is a dearth of such evidence in Indian s…
Fengjuan Wang, Lei Zhou, Xiaoyan Hao, Jiayun Liu
…pathogens and is a contributing factor to the occurrence of tuberculosis infection. The primary objective of this investigation was to examine the risk factors for the progression from latent tuberculosis infection (LTBI) to active tuberculosis (ATB) in patients with rheumatic di…
Hanthamrongwit J, Aruvornlop P, Saelee C, Wanta N, Poneksawat P, et al.
Multi-stage tuberculosis (TB) vaccines composed of active- and dormancy-associated antigens are promising to trigger the immune protection against all TB stages. However, scientists are still in quest of the suitable vaccine candidates. In this study, we identified the potential …
Qiu B, Liu Q, Li Z, Song H, Xu D, et al.
…ents, a sensitive and specific method to distinguish active tuberculosis from latent tuberculosis infection (LTBI) would allow for early diagnosis and limit the spread of the pathogen. The analysis of multiple cytokine profiles provides the possibility to differentiate the two di…
Sun T, Wu B, Wang J, Yuan T, Huang H, et al.
…is important to distinguish those with active Mycobacterium tuberculosis infection (ATB) from latent tuberculosis infection (LTBI) for monitoring and treating the disease. Monocytes play an important role and may undergo morphological changes against active TB infection. The aim …
Rebeiro PF, Cohen MJ, Ewing HM, Figueiredo MC, Peetluk LS, et al.
Background Tuberculosis (TB) elimination requires treatment of millions of persons with latent M. tuberculosis infection (LTBI). LTBI treatment acceptance depends on population-wide TB knowledge and low stigma, but limited data are available on the relationship between stigma and…
Meier NR, Battegay M, Ottenhoff THM, Furrer H, Nemeth J, et al.
…In individuals living with HIV infection the development of tuberculosis (TB) is associated with rapid progression from asymptomatic TB infection to active TB disease. Sputum-based diagnostic tests for TB have low sensitivity in minimal and subclinical TB precluding early diagnos…
Seers T, Quah H, Ludwig D, Noursadeghi M, Brown M, et al.
…ing for an aetiology. Despite previous treatment for latent tuberculosis, he developed changes typical for miliary tuberculosis and was started on antituberculosis therapy; whole genome sequencing later demonstrated isoniazid monoresistance. This case demonstrates both the import…
Aravindhan V, Yuvaraj S
Tuberculosis patients with diabetes, have higher sputum bacillary load, delayed sputum conversion, higher rates of drug resistance, higher lung cavitary involvement and extra-pulmonary TB infection, which is called as "Diabetes-Tuberculosis Nexus". However, recently we have shown…
Wang S, Wu J, Chen J, Gao Y, Zhang S, et al.
…n tests offer several advantages for the rapid diagnosis of tuberculosis (TB). The Mycobacterium tuberculosis-specific antibody responses associated with different stages of TB infection remain to be investigated. Methods The Pathozyme-Myco IgG (Myco G), Pathozyme TB Complex Plus…