Showing 76–100 of 200 documents
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Ting Liu, Lei Zhang, Jiao Liu, Yao Liu, Anying Xiong, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major global cause of mortality and is a leading cause of death among women of reproductive age (WRA). Untreated TB in this population endangers both maternal and neonatal health, yet the age-stratified burden and the shifting distribut…
Wang T, Yang Q, Gao Y, Zhang R, Zhou C, et al.
…nifestations of rifampicin primary drug-resistant pulmonary tuberculosis in Liangshan Yi Autonomous Prefecture. Patients and methods A total of 100 inpatients with confirmed primary rifampicin-resistant pulmonary tuberculosis were recruited from January 2020 to December 2022 at a…
Marie Wijk, Paolo Denti, Kamunkhwala Gausi, Bronwyn Myers, Tara Carney, et al.
**BACKGROUND:** Quantitative markers of tuberculosis disease burden are essential for assessing treatment response and optimizing therapeutic strategies. This study evaluated the impact of antimicrobial plasma drug levels on time-to-positivity (TTP) trajectories in patients with …
Walsh KF, McAulay K, Lee MH, Vilbrun SC, Mathurin L, et al.
…d in treatment-naive adults with drug-susceptible pulmonary tuberculosis in Port-au-Prince, Haiti, to assess the safety, bactericidal activity, and pharmacokinetics of nitazoxanide (NTZ). This was a prospective phase II clinical trial in 30 adults with pulmonary tuberculosis. Twe…
Serebryakova VA, Urazova OI, Novitsky VV, Vengerovskii AI, Kononova TE, et al.
…blood lymphocytes from patients with infiltrative pulmonary tuberculosis were studied in vitro. It was found that levofloxacin stimulated apoptotic cell death in tuberculosis. Addition of levofloxacin to cell suspension from patients with drug-susceptible form of tuberculosis led…
Lun S, Tasneen R, Chaira T, Stec J, Onajole OK, et al.
…l wall-associated mycolic acid transporter of Mycobacterium tuberculosis In the present study, we characterized indoleamide effects on bacterial cell morphology and reevaluated pharmacokinetics and in vivo efficacy using an optimized oral formulation. Morphologically, indoleamide…
Nikonov SD, Bredikhin DA, Belogorodtsev SN, Schwartz YS
…ed for effective photodynamic inactivation of Mycobacterium tuberculosis at a constant dose of aluminum phthalocyanine. Reference laboratory drug-susceptible strain H37Rv and clinical isolates of M. tuberculosis with varying degrees of resistance to antibiotics were used. Suspens…
Hamid M, Brooks MB, Madhani F, Ali H, Naseer MJ, et al.
Objective Pakistan has a high pediatric burden of tuberculosis, but few studies describe the treatment experience of children with tuberculosis in Pakistan. We sought to identify risk factors for unsuccessful treatment outcomes in children with drug-susceptible tuberculosis ident…
Colangeli R, Jedrey H, Kim S, Connell R, Ma S, et al.
…ckground Approximately 5% of patients with drug-susceptible tuberculosis have a relapse after 6 months of first-line therapy, as do approximately 20% of patients after 4 months of short-course therapy. We postulated that by analyzing pretreatment isolates of Mycobacterium tubercu…
Sejie GA, Mahomed OH
Background Eliminating Tuberculosis is one of the targets of Sustainable Development Goal Three. Decentralizing TB care beyond health facilities by leveraging community involvement is crucial for safeguarding effective tuberculosis care. In this study, we explored potential facil…
Reddy KP, Horsburgh CR, Wood R, Fields NF, Girouard MP, et al.
Rationale: Recent tuberculosis treatment trials failed to show that some 4-month (4m) regimens were noninferior to conventional 6-month (6m) regimens for a composite clinical outcome. Novel shortened regimens may still have important clinical and economic benefits in populations …
Kim HJ, Lee YJ, Song MJ, Kwon BS, Kim YW, et al.
Rifampicin is an important agent for tuberculosis treatment; however, it is often discontinued because of adverse reactions. The treatment regimen then can be administered as that for rifampicin-resistant tuberculosis, which can be toxic. We retrospectively reviewed 114 patients …
Ekaterina V Kurbatova, Kelly E Dooley, Wendy Carr, Jason E Stout, Eric L Nuermberger, et al.
…t shorten treatment duration for drug-susceptible pulmonary tuberculosis. **METHODS/DESIGN:** We describe the design of Tuberculosis Trials Consortium (TBTC) Study 38/CRUSH-TB (NCT05766267), an open-label multicenter international randomized controlled phase 2C trial that compar…
Lee H, Bea S, Kim JH, Jeong HE, Jang SH, et al.
…tives The clinical importance of adhering to the regimen in tuberculosis patients has been widely investigated, but most studies were conducted in controlled settings and in limited populations. We aimed to measure the level of real-world adherence during intensive phase and inve…
Haile H, Tema L, Anjulo A, Temesgen Z, Jerene D
…stimated incidence to be about 2-5% of overall total cases. Tuberculosis ARDS and septic shock are rare but carries extremely poor prognosis. Case summary A 27 year old male with advanced HIV disease with very low CD4 count presented to Wolaita Sodo University comprehensive speci…
Wang WF, Lu MJ, Cheng TR, Tang YC, Teng YC, et al.
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, kills over 1 million people worldwide annually. Development of drug resistance (DR) in the pathogen is a major challenge for TB control. We conducted whole-genome analysis of seven Taiwan M. tuberculos…
Li P, Wang B, Zhang X, Batt SM, Besra GS, et al.
…aluated for their in vitro activities against Mycobacterium tuberculosis and cytotoxicity against Vero cell line. Among these three series, the benzothiopyranone series displayed excellent antimycobacterial activity and low cytotoxicity. In particular, compound 6b exhibited poten…
Welekidan LN, Yimer SA, Skjerve E, Dejene TA, Homberset H, et al.
Background: Tuberculosis, mainly caused by Mycobacterium tuberculosis (Mtb), is an ancient human disease that gravely affects millions of people annually. We wanted to explore the genetic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuber…
Saag L, Rebeiro P, Cordeiro-Santos M, Kritski A, Andrade B, et al.
…first two months of anti-TB therapy) is a predictor of poor tuberculosis (TB) treatment outcomes among HIV-negative populations, but the relationship has not been well studied in the context of HIV. We examined the association between HIV and weight change during the first two mo…
Subbaraman R, Thomas BE, Kumar JV, Lubeck-Schricker M, Khandewale A, et al.
Background Nonadherence to tuberculosis medications is associated with poor outcomes. However, measuring adherence in practice is challenging. In this study, we evaluated the accuracy of multiple tuberculosis adherence measures. Methods We enrolled adult Indians with drug-suscept…
Salazar-Austin N, Mulder C, Hoddinott G, Ryckman T, Hanrahan CF, et al.
… live in the household of someone with infectious pulmonary tuberculosis are at a high risk of tuberculosis infection and subsequent progression to tuberculosis disease. These individuals are prioritized for contact investigation and tuberculosis preventive treatment (TPT). The t…
Du W, Zhao Y, Zhang C, Zhang L, Zhou L, et al.
…ns can be influenced by the susceptibility of Mycobacterium tuberculosis (MTB) can provide valuable information for preventing and treating drug resistant tuberculosis (DR-TB). High-throughput 16S rRNA sequencing was employed to analyze the bacteriome in pulmonary TB lesions from…
Du W, Zhao Y, Zhang C, Zhang L, Zhou L, et al.
…ns can be influenced by the susceptibility of Mycobacterium tuberculosis (MTB) can provide valuable information for preventing and treating drug resistant tuberculosis (DR-TB). High-throughput 16S rRNA sequencing was employed to analyze the bacteriome in pulmonary TB lesions from…
Muda MR, Albitar O, Harun SN, Syed Sulaiman SA, Hyder Ali IA, et al.
… or relapse among drug susceptible smear-positive pulmonary tuberculosis patients. Several contributing factors have been identified in many studies, but the results varied across regions and countries. Therefore, the current study aimed to develop a predictive model that explain…
Tafaj S, Mokrousov I, Borroni E, Trovato A, Kapisyzi P, et al.
…bania is a Balkan country with moderate to low incidence of tuberculosis (TB) and very low prevalence of drug resistant TB. Here, we analyzed a country-wide multi-year Mycobacterium tuberculosis collection in order to detect possible dynamic trends of TB in Albania, with a focus …