Showing 76–100 of 200 documents
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Bermawi B, Kurniasari DW, Imaniar A, Hidayatih N, Lisnawati DA, et al.
Introduction Tuberculosis (TB) is a serious global health problem in Indonesia, which is the country with the secondhighest TB burden after India. Accuracy in TB diagnosis is the key to effective treatment and decreased transmission rate. One of the latest diagnostic methods is i…
Barış Çil, Mehmet Sinan Bodur, Mehmet Kabak
**BACKGROUND:** The diagnosis of extrapulmonary tuberculosis (EPTB) often depends on advanced imaging, invasive tissue sampling, and multidisciplinary referral pathways. These complex, procedure-dependent diagnostic processes are particularly vulnerable to disruption during perio…
Kay A, Vasiliu A, Carratala-Castro L, Mtafya B, Mendez Reyes JE, et al.
…Reliance on sputum as the primary specimen for tuberculosis diagnostics contributes to this diagnostic gap. We evaluated the diagnostic accuracy and additive yield of a novel stool quantitative PCR (qPCR) assay for the diagnosis of tuberculosis in three countries in Africa with h…
Wang B, Wang Q, Li M, Yu J, Jiang F, et al.
…t yet discussed in current literature as a means for TB-IAI diagnostics. Here we describe a cohort of patients with TB-IAI diagnosed by mNGS show high efficiency of mNGS for detection of this pathology and present a clinical algorithm supplementing conventional methods for TB-IAI…
Vijay Pratap, Astha Lalwani, Ankur Malhotra
…synechiae were seen in 46% and 18%, respectively. Molecular diagnostics GeneXpert and tuberculosis-polymerase chain reaction (TB-PCR) showed high sensitivity (up to 100%) and varied specificity (33% to 100%). The prevalence of FGTB ranged from 6.73% to 45%, with conception rates …
He Y, Zhu Z, Chen Y, Chen F, Wang Y, et al.
Objectives Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) remains a diagnostic challenge. Misdiagnosis carries potential grave implications. We aimed to develop and validate a novel diagnostic nomogram for differentiating them. Methods In total, 310 eligi…
Seki M, Kim CK, Hayakawa S, Mitarai S
…iagnostic methodologies for TB, and the impact of those new diagnostics on TB control in such situations. Moreover, the perspective of TB management based on laboratory examinations is described. Smear microscopy with sputum samples is the only laboratory examination available in…
Assebe LF, Erena AK, Fikadu L, Alemu B, Baruda YS, et al.
…ational TB guideline recommends the primary use of rapid TB diagnostics whenever feasible, there is limited evidence available that assess the efficiency of deploying various diagnostic tools in the country. Hence, this study aims to evaluate the cost-effectiveness of rapid TB/MD…
Xuegang Zhou, Nan Tang, Xiuqing Liao, Xiaoli Bao
**BACKGROUND:** Bronchoalveolar lavage fluid (BALF) Xpert Mycobacterium tuberculosis and rifampicin resistance (Xpert MTB/RIF) is increasingly used as an important diagnostic method for sputum smear-negative pulmonary tuberculosis (PTB) in many countries. However, no studies have…
Niti Sureka, Smriti Sharan, Charanjeet Ahluwalia, Sana Ahuja, Sunil Ranga
**BACKGROUND:** Pulmonary diseases represent a significant global health challenge, underscoring the need for accurate diagnostic methods to ensure effective management. Bronchoalveolar lavage (BAL) is an essential diagnostic tool, providing valuable insights into various lung co…
Birendra Gupta, Natalia Blanco, Chandramani Wagle, Nikita Acharya, Jyoti Takanche, et al.
**BACKGROUND:** Pyrexia of Unknown Origin (PUO) represents a persistent diagnostic challenge in clinical practice. In South Asian regions, this challenge is compounded by a high burden of endemic infections, resource constraints, and varied clinical practices. This systematic rev…
Du J, Shu W, Liu Y, Wang Y, Zhan Y, et al.
…l external quality assessment (EQA) panels for molecular TB diagnostics. In addition, we also assessed the performance of the laboratories with the EQA panels in China. Dried Mycobacterium tuberculosis (MTB) DNA in the chelex resin was designed as part of an EQA program. The stor…
Tandel N, Joseph AZ, Joshi A, Shrama P, Mishra RP, et al.
…formulation and their utilization in the field of molecular diagnostics for TB. The review also sheds a light on other nanoparticle-based molecular diagnostic approaches for TB. Despite the advent of science, we are yet to have a diagnostic tool that is simple, rapid, sensitive, …
Eduarda Rabello, Fernanda de-Paris
Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, a burden further exacerbated by HIV co-infection and the increasing prevalence of drug-resistant strains. Although a wide range of laboratory diagnostic methods are currently av…
Saini S, Prasad BM, Mahajan A, Duhan A, Jangra A, et al.
…from implementation indicate the need to strengthen private diagnostics through a certification process to ensure provision of quality TB diagnostic services.
Peerzada Ajaz A Shah, Mustafa Bashir, Moien Farooq, Tavseef A Tali, Toufeeq A Teli
**BACKGROUND:** Exudative pleural effusion is a common clinical problem with diverse etiologies, often requiring invasive procedures for definitive diagnosis. While conventional cytology is widely used, its diagnostic yield remains limited. Ancillary methods such as cell block (C…
Xuxiang Song, Qipan Zhang, Tiantian Cen, Wei Fan, Weili Chen, et al.
**OBJECTIVE:** This study aimed to assess Interleukin-39 (IL-39) levels in various types of pleural effusion (PE), explore IL-39's diagnostic value in tuberculous pleurisy, analyze its correlation with other PE and tuberculosis indicators, and confirm the involvement of IL-39 in …
Xie L, Zhu G, Long S, Wang M, Cheng X, et al.
Background Current diagnostic methods cannot effectively distinguish between latent tuberculosis infection (LTBI) and active tuberculosis (ATB). This study aims to explore novel non-invasive diagnostic biomarkers for LTBI and to elucidate possible molecular mechanisms of LTBI pat…
Li Y, Luo D, Zheng Y, Liu K, Chen S, et al.
Objective To understand and analyze the factors relating to patient and diagnostic delays among groups with tuberculous pleurisy (TP), and its spatiotemporal distribution in Zhejiang Province. Methods Data of all tuberculous pleurisy patients were collected from the existing Tube…
Khambati N, Song R, MacLean EL, Kohli M, Olbrich L, et al.
Background Tuberculosis (TB) is a leading cause of death in children, but many cases are never diagnosed. Microbiological diagnosis of pulmonary TB is challenging in young children who cannot spontaneously expectorate sputum. Nasopharyngeal aspirates (NPA) may be more easily coll…
Dimitri Daraselia, Ani Toloraia, Salome Tsertsvadze, Marika Todua
…elay. These cases highlight the limitations of conventional diagnostics in both pulmonary and pleural TB, particularly in smear- and polymerase chain reaction (PCR)-negative presentations. They underscore the importance of clinical vigilance and timely escalation to tissue-based …
Lehman A, Ellis J, Nalintya E, Bahr NC, Loyse A, et al.
…ve of this review is to highlight novel point-of-care (POC) diagnostics and treatment strategies that can facilitate OI screening and prophylaxis for persons with AHD. Methods We reviewed the WHO guidelines for recommendations for persons with AHD. We summarized the scientific li…
Zhang X, Meng Q, Miao R, Huang P
Background Tuberculous infection of T cell spot test (T-SPOT.TB) and adenosine deaminase (ADA) have a high diagnostic value in pleural effusion for tuberculous pleurisy. However, there were major differences in existing research in regard to the clinical application of the two tr…
Yerlikaya S, Holtgrewe LM, Broger T, Isaacs C, Nahid P, et al.
…ty target product profiles (TPPs) for new tuberculosis (TB) diagnostics to align end-user needs with test targets and specifications; nevertheless, no TB test meets these targets to date. The COVID-19-driven momentum in the diagnostics world offers an opportunity to address the l…
Bankole OT, Ajayi IO
The prevalence of tuberculosis (TB) and human immunodeficiency virus (HIV) coinfection in Nigeria is currently around 19.1%. This indicates that the two diseases are still a burden on the nation"s health. The aim of this study was to evaluate the diagnostic microbiology capacity …