Showing 76–100 of 200 documents
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Anurag Bhargava
Nutrition is essential to survival, health, and protection from disease across the lifespan. In the 1970s, an adequate diet was described as the most effective vaccine available for respiratory, diarrheal, and other common infections, as nutritional supplementation reduced these …
Adepoju VA, Onyezue OI
…ases and 1.4 million deaths in 2020 alone, new and improved vaccines are urgently needed. Recent advancements in TB vaccine research offer hope, but a lack of funding, coordination and understanding of immune responses have impeded progress. A TB Vaccine Accelerator Council aims …
Dockrell HM, Butkeviciute E
The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and…
Schaltz-Buchholzer F, Kjær Sørensen M, Benn CS, Aaby P
Background Following the introduction of oral Bacille Calmette-Guérin (BCG) a century ago, Albert Calmette suggested that BCG both provided protection against death from tuberculosis (TB) and other causes. The findings were not pursued. Today, there is considerable evidence that …
Wong NX, Buttery J, McMinn A, Azhar Z, Crawford NW
Bacille Calmete-Guerin vaccine is widely administered to reduce the risk of severe tuberculosis disease in children. Recent global vaccine supply issues have led to the use of alternative products, which may vary in side effect profile. We report on the safety of the Polish (More…
Liebler-Tenorio EM, Heyl J, Wedlich N, Figl J, Köhler H, et al.
…models to compare reactions to different mycobacteria or TB vaccines.
Stewart EL, Counoupas C, Quan DH, Wang T, Petrovsky N, et al.
…able protection; however, the development of more effective vaccines is hindered by a lack of defined correlates of protection (CoP) against M. tuberculosis . Pulmonary vaccine delivery is a promising strategy since it may promote lung-resident immune memory that can respond rapi…
Justiz Vaillant AA, Grella MJ
…unities alike. The gamut of diseases currently addressed by vaccines is extensive, encompassing diphtheria, tetanus, pertussis, poliomyelitis, measles, mumps, rubella, pneumococcal pneumonia, smallpox, sepsis, meningitis, hepatitis B, varicella-zoster, tuberculosis, cholera, rota…
Rappuoli R, Black S, Bloom DE
Most vaccines for diseases in low- and middle-income countries fail to be developed because of weak or absent market incentives. Conquering diseases such as tuberculosis, HIV, malaria, and Ebola, as well as illnesses caused by multidrug-resistant pathogens, requires considerable …
Kwon BE, Ahn JH, Park EK, Jeong H, Lee HJ, et al.
Early secretory antigenic target-6 (ESAT6) is a potent immunogenic antigen expressed in Mycobacterium tuberculosis as well as in some non-tuberculous mycobacteria (NTM), such as M. kansasii . M. kansasii is one of the most clinically relevant species of NTM that causes mycobacter…
Roces CB, Hussain MT, Schmidt ST, Christensen D, Perrie Y
…(lungs) have been considered for the development of subunit vaccines. Inert delivery systems such as poly (lactic-co-glycolic acid) (PLGA) are an interesting approach due to its approval for human use. However, PLGA suffers hydrolytic degradation when stored in a liquid environme…
Goudouris E, Aranda CS, Solé D
Objectives Since the beginning of its use for the prevention of tuberculosis (TB) in 1921, other uses of BCG (Bacillus Calmette-Guérin) have been proposed, particularly in the treatment of malignant solid tumors, multiple sclerosis, and other autoimmune diseases. Its beneficial i…
Wang J, Xie T, Ullah I, Mi Y, Li X, et al.
Concerns were brought to the attention of the journal's editorial office after the paper was published [...].
Kanipe C, Boggiatto PM, Putz EJ, Palmer MV
[This corrects the article DOI: 10.3389/fmicb.2022.1048648.].
Jeong YD, Lee K, Lee S, Park J, Kim HJ, et al.
…d to identify the extent of its association with individual vaccines, thereby contributing to the development of a more effective vaccination program. We used data on vaccine-associated facial paralysis from 1967 to 2023 (total reports, n = 131 255 418 418) from the World Health …
Dinga JN, Akinbobola JS, Afolayan FID, Njoh AA, Kassa T, et al.
…s including healthcare and the purchase and distribution of vaccines. This vulnerable situation has been exacerbated by the COVID-19 pandemic which disrupted and exposed the fragile nature of equitable access to vaccines for childhood immunisation globally. A systematic review an…
Agopian A, Young H, Quinlan S, Rice MM
…ases not only requires high coverage but also requires that vaccines are administered in a timely manner. Prior studies have examined the timing of vaccinations in Armenia and found that although vaccination coverage is high, children are not receiving the vaccinations in a timel…
Ullah I, Bibi S, Ul Haq I, Safia, Ullah K, et al.
…unogenicity and safety of the M72/AS01 E and MVA85A subunit vaccines. The M72/AS01 E is a novel peptide-based vaccine currently in progress, which may increase the protection level against TB infection. The MVA85A was a viral vector-based TB subunit vaccine being used in the clin…
José Victor Bortolotto Bampi, Ghislaine Gonçalez de Araujo Arcanjo, Karina Marques Santos, Michele Souza Ventura, Everton Ferreira Lemos, et al.
…obal threat, with unequal burden across populations. New TB vaccines are in development, and people deprived of liberty (PDL) represent a vulnerable group that may benefit from vaccination. This study evaluated acceptability of a hypothetical new TB vaccine and factors associated…
Sharma A, Kerkhoff AD, Haambokoma M, Shamoya B, Sikombe K, et al.
…ves To estimate intention to receive newly introduced adult vaccines among community members and healthcare workers (HCWs) in Lusaka, Zambia in the context of previous COVID-19 vaccine uptake and perceived disease threat and, identify trusted sources of vaccine information. Metho…
Palmer MV, Hwang S, Kanipe C, Putz EJ, Fernandes LGV, et al.
…ablished technique used for stabilizing bioproducts such as vaccines. Methods In the current study, cattle were vaccinated in two phases. In each phase, cattle were divided into three groups. Group 1 received BCG injected SQ, Group 2 received liquid BCG delivered to the posterior…
Badurdeen S, Marshall A, Daish H, Hatherill M, Berkley JA
Importance Bacillus Calmette-Guérin (BCG) vaccination is commonly delayed in infants who are preterm and have low birth weights (LBW) despite the association of early vaccination with better vaccination coverage and potentially nonspecific benefits for survival. Objective To dete…
Pelzer PT, Holleman M, Helinski MEH, Weinberg AL, Buis J, et al.
…t populations. To accelerate the clinical development of TB vaccines, a directory of clinical trial centres was established in sub-Saharan Africa (SSA) to assess capacity for conducting late-stage TB vaccine trials. Methods TB vaccine-related parameters were identified, and trial…
Xie Y, Tian X, Zhang X, Yao H, Wu N
Vaccines are known to function as the most effective interventional therapeutics for controlling infectious diseases, including polio, smallpox, rabies, tuberculosis, influenza and SARS-CoV-2. Smallpox has been eliminated completely and polio is almost extinct because of vaccines…
Jia Q, Masleša-Galić S, Nava S, Horwitz MA
… attenuated L. monocytogenes multiantigenic M. tuberculosis vaccines, especially the rLm5Ag(30) vaccine expressing a fusion protein of 23.5/Mpt64, TB10.4/EsxH, ESAT6/EsxA, CFP10/EsxB, and r30, enhances BCG-induced protective immunity against M. tuberculosis aerosol challenge. In …