Showing 76–100 of 200 documents
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Trigos AS, Goudey BW, Bedő J, Conway TC, Faux NG, et al.
The evolution of resistance to one antimicrobial can result in enhanced sensitivity to another, known as "collateral sensitivity." This underexplored phenomenon opens new therapeutic possibilities for patients infected with pathogens unresponsive to classical treatments. Intrinsi…
Utpat KV, Rajpurohit R, Desai U
Background Drug-resistant tuberculosis (DR-TB) is the most exigent and calamitous challenge encountered in treatment of TB. Extra pulmonary (EP) DR-TB poses a complex diagnostic and therapeutic challenge owing to myriad of presentations and paucibacillary nature. Data available o…
Sheikh BA, Bhat BA, Mehraj U, Mir W, Hamadani S, et al.
…easing burden of tuberculosis is mainly caused due to multi drug-resistance. The failure of conventional treatment has been observed in large number of cases. Drugs that are used to treat extensively drug-resistant tuberculosis are expensive, have limited efficacy, and have more …
Rêgo AM, Alves da Silva D, Ferreira NV, de Pina LC, Evaristo JAM, et al.
…ading cause of death. Mycobacterium tuberculosis antibiotic resistance is becoming increasingly common and disease control is challenging. Conventional drug susceptibility testing takes weeks to produce results, and treatment is often initiated empirically. Therefore, new methods…
Tao NN, Li YF, Song WM, Liu JY, Zhang QY, et al.
…ve This study was designed to identify the risk factors for drug-resistant tuberculosis (DR-TB) and the association between comorbidity and drug resistance among retreated pulmonary tuberculosis (PTB). Design A retrospective study was conducted among all the 36 monitoring sites i…
Singh V, Chibale K, Chibale K
" Drug resistance is an unavoidable consequence of the use of drugs; however, the emergence of multi-drug resistance can be managed by accurate diagnosis and tailor-made regimens. "Antimicrobial resistance (AMR), is one of the most paramount health perils that has emerged in the …
Desai U, Joshi JM
Background Drug-resistant tuberculosis (DR-TB) is a global problem with only 52% reported cure rate. Extrapulmonary (EP) DR-TB poses a formidable diagnostic, therapeutic challenge. We aimed to study their clinical profile and treatment outcomes under the programmatic setting. Mat…
Jiandong Yang, Pengwei Lou, Weisheng Zhang, Yanggui Chen, Yaoqin Lu, et al.
…ate the epidemic status and distribution characteristics of drug-resistantin Urumqi. From January 2019 to July 2024, all sputum culture-positivestrains were collected in Urumqi. Using the traditional solid-state proportion method for drug-sensitivity testing, we determined the re…
Wang G, Jiang G, Jing W, Zong Z, Yu X, et al.
The drug resistance prevalence data facilitates selection of the initial drug for treating multidrug-resistant tuberculosis (MDR-TB). The aim of this study was to investigate the prevalence and molecular characterization of seven additional types of drug resistances among MDR-TB …
Noorizhab MNF, Zainal Abidin N, Teh LK, Tang TH, Onyejepu N, et al.
Multidrug-resistant (MDR) or extensively drug-resistant (XDR) Tuberculosis (TB) is a major challenge to global TB control. Therefore, accurate tracing of in-country MDR-TB transmission are crucial for the development of optimal TB management strategies. This study aimed to invest…
Miiro E, Olum R, Baluku JB
Background Drug-resistant tuberculosis (DR-TB) is a threat to tuberculosis (TB) control. Extra-pulmonary forms of DR-TB (DR-epTB) are not well characterized. This review summarizes the clinical features, resistance patterns and treatment outcomes of DR-epTB. Methods We searched E…
Okumu A, Orwa J, Sitati R, Omondi I, Odhiambo B, et al.
Multidrug-resistant tuberculosis (MDR-TB) is caused by M. tuberculosis ( Mtb ) with resistance to the first-line anti-TB medicines isoniazid (INH) and rifampicin (RIF). In Western Kenya, there is reported low prevalence of drug resistant strains among HIV tuberculosis patients, c…
Katran ZY, Bulut İ, Babalık A, Keren M, Tepetam FM, et al.
Objective To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods This was a retrospective study. The primary aim of the study is to determine the demographic and clinical characteristics of patients who develop drug …
Wang Z, Sun R, Mu C, Wang C, Zhao H, et al.
…cular characteristics of fluoroquinolone-resistant and multidrug-resistant M. tuberculosis strains using whole-genome sequencing to predict drug resistance in M. tuberculosis in Tianjin, China, which has not been established previously. Methods Twenty-one fluoroquinolone-resistan…
Shraddha Dalvi, Poulami Biswas, Shatabdi Bhagat, Nilma Hirani
…ng cause of death from a single infectious agent worldwide. Drug-resistant TB (DR-TB) poses a major challenge. Bedaquiline (BDQ) is central to multidrug resistant tuberculosis/extensively drug-resistant TB (MDR/XDR-TB) treatment, yet emerging resistance prompted this study to ass…
Hameed S, Ahmad SR, Rahman MAU, Nazir H, Ullah I
Objectives Drug-resistant tuberculosis (DR-TB) is a major challenge to national TB control programmes in developing countries. In the Pakistan province of Punjab, the extent and development of DR-TB is not well known. The current study was therefore conducted to assess the incide…
Lies Dina Liastuti, Kelvin Kohar, Haifa Mayang Lestari, Armalya Pritazahra
**BACKGROUND:** Drug-resistant tuberculosis remains a major public health challenge with substantial associated morbidity and mortality. Management requires complex, individualized treatment regimens. Emerging evidence suggests that contemporary antituberculosis agents for drug-r…
Rana HK, Singh AK, Kumar R, Pandey AK
…culosis (TB). TB control programmes are facing threats from drug resistance. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strains need longer and more expensive treatment with many medications resulting in more adverse effects and decreased chances of treatm…
Li Q, Zhao G, Wu L, Lu M, Liu W, et al.
Background To evaluate prevalence and patterns of drug resistance among pulmonary tuberculosis (TB) patients in Hangzhou City, China. Methods Sputum samples of smear positive TB patients enrolled in 2011 and 2015 were collected and tested for drug susceptibility, and demographic …
Pan Y, Yu Y, Lu J, Yi Y, Dou X, et al.
Purpose The emergence of drug-resistant tuberculosis (DR-TB) represents a threat to the control of tuberculosis. This study aimed to estimate the patterns and trends of DR-TB in patients with suspected DR-TB. In addition, risk factors for multidrug-resistant tuberculosis (MDR-TB)…
Ruesen C, Riza AL, Florescu A, Chaidir L, Editoiu C, et al.
Mycobacterium tuberculosis drug resistance poses a major threat to tuberculosis control. Current phenotypic tests for drug susceptibility are time-consuming, technically complex, and expensive. Whole genome sequencing is a promising alternative, though the impact of different dru…
Pedro Gomes, Paulo Paixão, Fernando Maltez, Laura Brum, Jody E Phelan, et al.
…tuberculosis (TB) in Western Europe and, historically, multidrug-resistant (MDR) cases have been strongly associated withstrains pertaining to the endemic Q1 and Lisboa3 clades. Notwithstanding, the contribution of drug resistance-associated allelic configurations in these clades…
Yunusbaeva M, Borodina L, Alekseev P, Davydov R, Yunusbaev U, et al.
…ountries, is characterized by one of the highest burdens of drug-resistant tuberculosis. Published data on the drug-resistant tuberculosis for these countries are limited, and it is not clear whether current treatment regimens remain effective against constantly evolving drug-res…
Anderson K, Pietersen E, Dheda K, van der Heijden YF
Background Simplified drug-resistant tuberculosis (DR-TB) treatment outcome definitions, mostly centred around receipt of treatment and sputum culture status at 6 months after treatment initiation, have been proposed, but have not been widely evaluated in resource-limited setting…
Ogari CO, Nyamache AK, Nonoh J, Amukoye E
…as to determine the prevalence of mutations responsible for drug resistance in Mycobacterium tuberculosis among patients visiting selected health centers in Nairobi, Kenya. Methods The cross-sectional study involved 132 TB positive patients visiting Mbagathi and Chandaria hospita…