Showing 51–75 of 200 documents
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Chaiyachat P, Kaewseekhao B, Chaiprasert A, Kamolwat P, Nonghanphithak D, et al.
…of pre-extensively (pre-XDR) and extensively drug-resistant tuberculosis (XDR-TB) is challenging. Drug-susceptibility tests for some anti-TB drugs, especially ethambutol (ETH) and ethionamide (ETO), are problematic due to overlapping thresholds to differentiate between susceptibl…
Merker M, Rasigade JP, Barbier M, Cox H, Feuerriegel S, et al.
…ansmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the largest single contributor to human mortality due to antimicrobial resistance. A few major clades of the Mycobacterium tuberculosis complex belonging to lineage 2, responsible for high prevalence…
Omar SV, Louw G, Ismail F, Liu X, Ngcamu D, et al.
Drug-resistant tuberculosis (TB) poses a significant public health concern in South Africa due to its complexity in diagnosis, treatment, and management. This study assessed the diagnostic performance of the Xpert MTB/XDR test for detecting drug resistance in patients with TB by …
Lin M, Chen YW, Li YR, Long LJ, Qi LY, et al.
…-based assays used for the rapid diagnosis of Mycobacterium tuberculosis (MTB) and drug-resistant tuberculosis (DR-TB). But studies on its performance are insufficient. Thus, in this study, we conducted a systematic review and meta-analysis to evaluate the effect of LPAs in the d…
Younghun Kim, Da-Gyum Lee, Jinyoung Bae, Jihee Jung, Hyeongrin Jeon, et al.
…tidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB); however, mutations related to LZD resistance still need to be characterised. This study investigated resistance-related mutations on a whole-genome scale in clinical isolates from patients with MDR/XDR…
Xu Y, Li Q, Zhu M, Wu X, Wang D, et al.
…idemiological characteristics and profile of drug-resistant tuberculosis (DR-TB) among children with TB in Sichuan province of China.From January 2015 to December 2018, microbiological culture-confirmed child TB cases (aged <15 years old) were enrolled retrospectively. Epidemiolo…
Sharma A, De Rosa M, Singla N, Singh G, Barnwal RP, et al.
Tuberculosis (TB) is a slow growing, potentially debilitating disease that has plagued humanity for centuries and has claimed numerous lives across the globe. Concerted efforts by researchers have culminated in the development of various strategies to combat this malady. This rev…
Mokry J, Porvaznik I, Kusnir P, Dohal M, Solovic I
The incidence of tuberculosis (TB) in some countries increases continuously, especially caused by mycobacterial strains resistant to various anti-tuberculotic drugs (AT). The emergence and spread of drug-resistant tuberculosis (multidrug-resistant - MDR-TB, and extensively drug-r…
Burhan E, Karyana M, Karuniawati A, Kusmiati T, Wibisono BH, et al.
…are lower than global testing rates per the 2020 WHO global tuberculosis (TB) report, prevalence of multidrug-resistant TB may be underestimated. Our study aimed to evaluate prevalence and patterns of TB drug resistance (DR) within Indonesia. We conducted a cross-sectional analys…
Osei-Wusu S, Amo Omari M, Asante-Poku A, Darko Otchere I, Asare P, et al.
Background Drug resistance surveillance is crucial for tuberculosis (TB) control. Therefore, our goal was to determine the prevalence of second-line anti-TB drug resistance among diverse primary drug-resistant Mycobacterium tuberculosis complex (MTBC) isolates in Ghana. Materials…
Basingnaa A, Antwi-Baffour S, Nkansah DO, Afutu E, Owusu E
The emergence of multidrug-resistant tuberculosis (MDR⁻TB) and more recently, extensively drug-resistant (XDR) TB has intensified the need for studies aimed at identifying factors associated with TB drug resistance. This study determined the differences in plasma concentrations o…
Ncha R, Variava E, Otwombe K, Kawonga M, Martinson NA
…s predictive of TTSCC in patients with multi-drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in the North-West Province. Methods A retrospective cohort study, abstracting patient demographic and clinical data, laboratory results, dates of…
Shaik J, Pillay M, Moodley J, Jeena P
…demiology and drug susceptibility patterns of Mycobacterium tuberculosis (MTB) of children and their household contacts (HHC) in Umlazi, a high TB-burden township in South Africa. Sixty eight MTBRifPLUS positive TB-infected children (TIC) (≤14 years) and 111 HHC were enrolled. Dr…
Benremila D, Djoudi F, Gharout-Sait A, Kheloufi S, Spitaleri A, et al.
…un on the Illumina NextSeq500 System. Among 82 isolates, 21 tuberculosis (TB) isolates (25.6%) were drug resistant, including 10 MDR and 4 pre-extensively drug-resistant (XDR)-TB. The mutation Ser315Thr in the kat G gene was confirmed in 15 isolates. In rpo B, Ser450Leu and His44…
Ketema T, Tadesse M, Bonsa Z, Balay G, Kebede W, et al.
…f drug resistance, including resistance to second-line anti-tuberculosis (TB) drugs, is crucial for the effective control and management of pre-extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB). The Xpert MTB/XDR assay is the WHO recommended me…
Meskini M, Zamani MS, Amanzadeh A, Bouzari S, Karimipoor M, et al.
…d-dendritic cells (mo-DCs) in connection with Mycobacterium tuberculosis (MTB) infection, with particular emphasis on pro/ anti-inflammatory genes. Methods In the context of this investigation, mo-DCs were infected by various active strains of MTB (Rifampicin-resistant [RIFR], H3…
Girase R, Ahmad I, Patel H
…st 35 years. It exhibits bacteriostatic efficacy against M. tuberculosis and is a crucial constituent of the BPaL regimen (Bedaquiline, Pretomanid, and Linezolid), which was authorized by the FDA in 2019 for the treatment of XDR-TB or MDR-TB. Despite its unique mechanism of actio…
Buziashvili M, Davtyan H, Sereda Y, Denisiuk O, Gozalov O, et al.
Considering the complexity of second-line anti-tuberculosis (TB) treatment regimens, the management of drug-resistant TB (DR-TB) in Georgia remains a major challenge. Since the introduction of new and repurposed anti-TB medications, the implementation of active TB Drug Safety Mon…
Salindri AD, Kipiani M, Lomtadze N, Tukvadze N, Avaliani Z, et al.
…e relationship between common comorbidities in persons with tuberculosis (TB) (including human immunodeficiency virus [HIV], diabetes, and hepatitis C virus [HCV]) and post-TB mortality. We conducted a retrospective cohort study among persons who initiated treatment for rifampici…
Kuchukhidze G, Baliashvili D, Adamashvili N, Kasradze A, Kempker RR, et al.
…mong patients with multidrug and extensively drug-resistant tuberculosis (M/XDR TB). We aimed to identify long-term clinical outcomes of patients who were LFU during second-line TB treatment. Methods We conducted a follow-up study among adults who received second-line TB treatmen…
Prasitpuriprecha C, Jantama SS, Preeprem T, Pitakaso R, Srichok T, et al.
…rm for determining if a patient is positive or negative for tuberculosis and classifying several types of drug resistance. The constructed model is evaluated and compared to current methods described in the literature. The proposed model was assessed using two datasets of chest X…
Francesca Saluzzo, Andrea Maurizio Cabibbe, Richard Anthony, Alexandra Aubry, Francis Drobniewski, et al.
…rted poor treatment outcomes for extensively drug-resistant tuberculosis (TB) in the European region highlight the urgent need for effective and context-appropriate diagnostic strategies. While the World Health Organisation (WHO) provides model algorithms, these require adaptatio…
Maïssala Zoutené, Akouvi Mawussé Edjodjinam Ako, Koffi Atsu Aziagbe, Narcisse Viani Gateu Tadjom, Tété Amento Stéphane Adambounou, et al.
…IVES:** The increasing burden of extensively drug-resistant tuberculosis (XDR-TB) undermines global TB control efforts. **METHODS:** This was a case series study conducted from January 1, 2007, to December 31, 2024, in the Department of Pulmonology at Sylvanus Olympio University…
Matúš Dohál, Olha Konstantynovska, Michaela Hromádková, Marek Štrba, Karolína Doležalová, et al.
…d migration into Central Europe, raising concerns regarding tuberculosis (TB) spread. **METHODS:** We conducted a molecular-epidemiological study including all Ukrainian migrants with culture-confirmed TB in Slovakia and the Czech Republic between September 2021 and December 202…
Zhao LL, Huang MX, Xiao TY, Liu HC, Li MC, et al.
…valence, risk and genetic characteristics of drug-resistant tuberculosis (TB) from a tertiary care TB hospital in China. Patients and methods We carried out a retrospective study including isolates from 189 patients with pulmonary TB at Fuzhou Pulmonary Hospital. All isolates fro…