Showing 51–75 of 200 documents
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Qiu X, Tang Y, Zou R, Zeng Y, Yue Y, et al.
…-gamma release assay are not good at differentiating active tuberculosis from latent tuberculosis. Interferon-gamma-induced protein 10 (IP-10) has been widely used to detect tuberculosis infection. However, its values of discriminating active and latent tuberculosis is unknown. T…
Graves SK, Augusto O, Viegas SO, Lederer P, David C, et al.
…can healthcare workers have high rates of latent and active tuberculosis, but occupational screening for tuberculosis is not routine in this setting. Furthermore, the specificity of tuberculin skin testing in this population compared with interferon gamma release assay testing ha…
Hirai N, Kasahara K, Yoshihara S, Nishimura T, Omori K, et al.
…d man with primary myelofibrosis who developed disseminated tuberculosis during treatment with ruxolitinib at 15 mg twice daily and prednisone at 5 mg. We also reviewed the literature on patients who developed tuberculosis during treatment with ruxolitinib. There are 13 case repo…
Rabe H, Lönnermark E, Johansson E, Gilljam M, Jönsson B
Mycobacterium tuberculosis and opportunistic environmental non-tuberculous mycobacteria (NTM) can cause severe infection. Why latent tuberculosis infection advances to active disease, and why some individuals with cystic fibrosis (CF) develop pulmonary infections with NTM is stil…
Fang Y, Wang N, Tang L, Yang XJ, Tang Y, et al.
Background Active tuberculosis (ATB) originates from primary Mycobacterium tuberculosis (MTB) infection or reactivation of latent tuberculosis. Besides bacteriological examination, MTB-reactive immunocytes detection can be an alternative testing for discrimination of active tuber…
Ikuta K, Ota Y, Kuroki S, Matsumoto Y, Senda E, et al.
Treatment of latent tuberculosis infection (LTBI) reduces the probability of reactivation of tuberculosis associated with anti-tumor necrosis factor (TNF) α inhibitors, but no chemoprophylaxis is completely protective. We herein report a woman with rheumatoid arthritis who develo…
Tsolaki AG, Varghese PM, Kishore U
Innate immunity against Mycobacterium tuberculosis is a critical early response to prevent the establishment of the infection. Despite recent advances in understanding the host-pathogen dialogue in the early stages of tuberculosis (TB), much has yet to be learnt. The nature and c…
Miyazaki S, Fujita K, Ozaki S, Ichiyama S, Ito M, et al.
…is generally effective in preventing reactivation of latent tuberculosis infection (LTBI), prophylactic measures do not fully protect against development of active tuberculosis. We report a rare case of active tuberculosis despite chemoprophylaxis for LTBI in a patient receiving …
Bielecka T, Augustynowicz-Kopeć E, Gonerko P, Gruszczyński P, Korzeniewska-Koseła M, et al.
Since the second half of the 20th century the incidence of tuberculosis has been declining in Poland. Despite this, current epidemiological data still support the need for the continued mass BCG vaccination in Poland in the near future. Apart from the protection against severe he…
Ralph A Stidham, Rachel G Tyler
Tuberculosis (TB) remains a force health protection threat to the U.S. military, particularly in crucial populations at increased risk of exposure or re-activation. This analysis examined TB testing trends and the prevalence of latent tuberculosis infection (LTBI) among U.S. Army…
Stidham RA, Tyler RG
Tuberculosis (TB) remains a force health protection threat to the U.S. military, particularly in crucial populations at increased risk of exposure or re-activation. This analysis examined TB testing trends and the prevalence of latent tuberculosis infection (LTBI) among U.S. Army…
Iba A, Tomio J, Yamana H, Sugiyama T, Yoshiyama T, et al.
Background and aim Screening for tuberculosis before treating with biologic agents is recommended in patients with immune-mediated inflammatory diseases (IMIDs). We conducted this study to identify adherence to the recommended practice in a real-world setting in Japan. Methods We…
Haerana BT, Prihartono NA, Riono P, Djuwita R, Syarif S, et al.
Background Children who inhabit the same house with tuberculosis (TB) patients are at high risk for infection and illness with TB. Nutritional status (stunting) in children is related to the child's ability to withstand MTB (Mycobacterium Tuberculosis). This study aims to estimat…
Achkar JM, Prados-Rosales R
A more effective vaccine to control tuberculosis (TB), a major global public health problem, is urgently needed. Current vaccine candidates focus predominantly on eliciting cell-mediated immunity but other arms of the immune system also contribute to protection against TB. We rev…
Gong W, Liang Y, Wang J, Liu Y, Xue Y, et al.
Latent tuberculosis infection (LTBI) is the primary source of tuberculosis (TB) but there is no suitable detection method to distinguish LTBI from active tuberculosis (ATB). In this study, five antigens of Mycobacterium tuberculosis belonging to LTBI and regions of difference (RD…
Sharma S, Bhat R, Singh R, Sharma S, Wazir P, et al.
One of the significant challenges to treat tuberculosis is the phenotypic resistance adapted by the latent or dormant Mycobacterium tuberculosis (M. tuberculosis) cells against most of the available drugs. Different in-vitro assay such as oxygen depletion model and nutrient starv…
López-Ramos JE, Macías-Segura N, Cuevas-Cordoba B, Araujo-Garcia Z, Bastián Y, et al.
Background Pulmonary tuberculosis (PTB) is a public health problem with 10.4 million new cases reported in 2017 (1). According to the World Health Organization (WHO), accurate diagnostic tests based in serum biomarkers to detect new cases of tuberculosis are necessary. Aim of the…
Çavuşoğlu C, Çoğulu Ö, Durmaz A, Cengisiz Z, Yılmaz FF, et al.
… of the miRNA and cytokine expression levels, the course of tuberculosis infection, clinical forms and response to treatment, and (ii) the effects of genotypic features of bacteria on the course of tuberculosis and the relationship between miRNA and cytokine expressions and bacte…
Adankwah E, Lundtoft C, Güler A, Franken KLMC, Ottenhoff THM, et al.
…FERON (QFT)] are widely used for diagnosis of Mycobacterium tuberculosis ( Mtb ) infection. T-cell responses against QFT antigens ESAT6 and CFP10 are highly Mtb specific but previous studies indicated suboptimal assay sensitivity. Especially for potentially infected healthy conta…
Kuscu F, Yildirim F, Erturk D, Cabalak M, Komur S, et al.
Background About 10% of individuals with latent tuberculosis infection (LTBI) develop tuberculosis (TB) disease during their lifetime. People living with HIV (PLWH) have a significantly higher risk of developing tuberculosis disease from latent tuberculosis infection (LTBI) compa…
Reece ST, Vogelzang A, Tornack J, Bauer W, Zedler U, et al.
Persistence of Mycobacterium tuberculosis within human bone marrow stem cells has been identified as a potential bacterial niche during latent tuberculosis. Using a murine model of tuberculosis, we show here that bone marrow stem and progenitor cells containing M. tuberculosis pr…
Feng PI, Horne DJ, Wortham JM, Katz DJ
Objective Little is known about regimen choice for latent tuberculosis infection in the United States. Since 2011, the Centers for Disease Control and Prevention has recommended shorter regimens-12 weeks of isoniazid and rifapentine or 4 months of rifampin-because they have simil…
Juste RA, Fernández-Veiga L, Fuertes M, Fernández-Ortiz de Murua I, Cardona G, et al.
Tuberculosis (TB) is a disease caused by members of the M. tuberculosis complex (MTC) that affects numerous species. M. caprae, a member of the complex which is close to M. bovis, is emerging and affects several different hosts that include goats, cattle, sheep, pigs, rabbits, wi…
Florence Mutua, Ruey-Chyi Su, Terry Blake Ball, Sandra Kiazyk
…ype I interferon-induced transcriptomic signature in active tuberculosis suggests a potential role for these interferons in the pathogenesis of tuberculosis. Comorbidities such as human immunodeficiency virus, diabetes, systemic lupus erythematosus, end-stage renal disease, and c…
Purba BB, Sembiring RJS, Sitorus FE, Fahdi F, Purba D
…ound Indonesia reported the second-highest global burden of tuberculosis after India, with a 2.6% increase in cases from the previous year. Objective This study aimed to evaluate case-finding of latent tuberculosis infection (LTBI) and differences in tuberculin induration diamete…