Showing 51–75 of 200 documents
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Shanbag N, Haseeb M, Engade M, Siddiqui MS, Badaam KM, et al.
Background The prevalence of tuberculosis (TB) disease among household contacts of adult TB patients is very high. Contact screening and isoniazid preventive therapy (IPT) are recommended for household contacts, but their uptake by families and implementation by the national TB p…
Faksri K, Xia E, Ong RT, Tan JH, Nonghanphithak D, et al.
Tuberculous meningitis (TBM) is a severe form of tuberculosis with a high mortality rate. The factors associated with TBM pathogenesis are still unclear. Using comparative whole-genome sequence analysis we compared Mycobacterium tuberculosis (Mtb) isolates from cerebrospinal flui…
Sibandze DB, Magazi BT, Malinga LA, Maningi NE, Shey BA, et al.
… There is a general dearth of information on extrapulmonary tuberculosis (EPTB). Here, we investigated Mycobacterium tuberculosis (Mtb) drug resistance and transmission patterns in EPTB patients treated in the Tshwane metropolitan area, in South Africa. Methods Consecutive Mtb cu…
Scherer J, Mukasa SL, Wolmarans K, Guler R, Kotze T, et al.
Background Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and typically infects the lungs. However, extrapulmonary forms of TB can be found in approximately 20% of cases. It is suggested, that up to 10% of extrapulmonary TB affects the musculoskeletal system, in …
Var A, Uysal Y, Kuruş M, Yeşiltaş YS, Bozlar U, et al.
Purpose Orbital/periorbital tuberculosis (TB) is an uncommon manifestation of extrapulmonary TB, presenting diagnostic challenges due to its varied clinical features that can mimic other diseases. This report aims to present a rare case of periorbital TB in a young man. Methods C…
Sharma K, Sharma M, Ayyadurai N, Dogra M, Sharma A, et al.
…IF Ultra (Ultra) was evaluated for the first time on Ocular tuberculosis (OTB) samples and compared with Xpert. Methods Seventy five vitreous fluid samples (3 confirmed OTB, 47 clinically suspected OTB, and 25 controls) were subjected to Ultra, Xpert and Multiplex-PCR and compare…
Kim M, Lee JH, Lee HN, Park DJ, Lee EJ
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (MTB), can affect the lungs (pulmonary TB) as well as other sites (extrapulmonary TB). Nasopharyngeal tuberculosis (NPTB) is a rare type of extrapulmonary TB. Since NPTB has nonspecific clinical present…
Kaur K, Sharma S, Abhishek S, Kaur P, Saini UC, et al.
Objectives Bone tuberculosis (TB) is the third most common types of extrapulmonary tuberculosis. It is critical to understand mycobacterial adaptive strategies within bone lesions to identify mycobacterial factors that may have role in disease pathogenesis. Methods Whole genome m…
Kaur K, Laal S, Ryndak MB
Introduction . Intraocular tuberculosis (IOTB) is a significant cause of visual morbidity in tuberculosis (TB)-endemic countries. Although Mycobacterium tuberculosis ( M. tb ) has been detected in both the retinal pigment epithelial (RPE) cells and in the intraocular fluid (IOF) …
Şahin Mavi EA, Akdemir MÇ, Akin AE, Uyaroğlu OA, Köksal D
Tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis (MTB). Although it typically affects the lungs (pulmonary TB), one-fifth of TB cases present as extrapulmonary TB. The diagnosis of extrapulmonary TB is often overlooked due to its atypical c…
Li H, Long Y, Shao F, Lan X
Extrapulmonary tuberculosis could involve multiple organs. However, thymic tuberculosis is relatively rare. We report a 21-year-old man who was referred for an F-FDG PET/CT imaging to assess his newly detected pulmonary nodule. The images showed the pulmonary nodule had minimal a…
Andrea Vejarano-Pombo, Sandra B Amado-Garzón, Javier I Lasso-Apráez, Sebastián Moreno-Mercado, Samuel Martínez-Vernaza, et al.
**BACKGROUND:** Extrapulmonary tuberculosis (EPTB) poses a public health challenge, particularly among individuals with human immunodeficiency virus (HIV). However, many EPTB cases arise in those without HIV, leaving the underlying factors unclear. **OBJECTIVES:** This study aim…
Risan NA, Febrianda RD, Nataprawira HM
…ale neonate with high suggestive of congenital disseminated tuberculosis (TB) [tuberculous meningitis (TBM), pulmonary TB, and ocular TB] at term, low birth weight born cesarean section from a confirmed COVID-19 and pulmonary TB mother who hospitalized in the isolation room and n…
Ngwira A, Manda S, Karimuribo ED, Kimera SI
…tion of common spatial disease trends between cattle bovine tuberculosis (BTB) and human extrapulmonary tuberculosis (EPTB) and drug-resistant tuberculosis (DRTB) can support integrated disease control and monitoring programmes. We employed the recently developed multivariate dis…
Muxing Chen, Fan Zhang, Yiping Liu, Youfei Lin, Di Wu, et al.
**BACKGROUND:** Central nervous system tuberculosis (CNS-TB) remains a critical clinical challenge with high mortality, and its underlying immunopathological mechanisms have not been fully elucidated. This study aimed to investigate age-dependent variations in T lymphocyte subset…
Mekonnen D, Munshea A, Nibret E, Adnew B, Herrera-Leon S, et al.
Background Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTBC), is a chronic infectious disease with both pulmonary and extrapulmonary forms. This study set out to investigate and compare the genomic diversity and transmission dynamics of Mycobacterium tube…
Ramachandran S, R P
Background The Xpert® mycobacterium tuberculosis complex/resistance to rifampin (MTB/RIF) test is widely recognized for its ability to provide rapid and accurate results for diagnosing tuberculosis (TB) in both pulmonary and extrapulmonary samples. Its utility is especially criti…
Riyadi Adrizain, Dyah Ayu Shinta Lesmanawati, Fadila Dyah Trie Utami, Anggraini Alam, Djatnika Setiabudi
…mune systems and more prone to secondary infections such as tuberculosis (TB).is a rare case but serious complication of COVID-19. It commonly affects the gastrointestinal, cardiovascular, hematologic, and mucocutaneous systems. This study presents a case of MIS-C in a 15-year-ol…
Addo SO, Mensah GI, Mosi L, Abrahams AOD, Addo KK
…tic diversity and drug resistance profiles of Mycobacterium tuberculosis complex (MTBC) isolates from extrapulmonary tuberculosis (EPTB) patients in Ghana, and their associated immune responses. Methods Spoligotyping was performed on 102 MTBC isolates from EPTB patients. Lineages…
Imrani K, El Youssfi Z, Acharki M, Belkouchi A, Billah NM, et al.
Tuberculosis is related to high rate of morbidity and mortality worldwide. Extra-pulmonary forms are increasing in incidence. The diagnosis of extrapulmonary locations, especially abdominal, is often difficult because the clinical and biological signs are not specific, leading to…
Mannava AS, Wesley Garapati CA, Ganguly S, Jaykar KC
Tuberculosis (TB) is caused by Mycobacterium tuberculosis and it can affect multiple organ systems. Cutaneous TB, a less common type of extrapulmonary TB can coexist with TB of other organs. Here, we describe a case of multifocal cutaneous TB suggestive of two different morpholog…
Nasrin R, Uddin MKM, Kabir SN, Rahman T, Biswas S, et al.
…t MTB/RIF Ultra (Ultra) for the diagnosis of extrapulmonary tuberculosis (EPTB) from different types of extrapulmonary specimens in comparison with culture and composite microbiological reference standard (CRS). A total of 240 specimens were prospectively collected from presumpti…
Niu T, Li Y, Ru C, Chen A, Shi Y, et al.
…risk factors, and complication characteristics of pulmonary tuberculosis (PTB) combined with extrapulmonary tuberculosis (EPTB) in elderly patients (aged > 60 years). Clinical data were collected from pathogen positive elderly patients with PTB hospitalized in a teaching hospital…
Noor AM, Ghazali SM, Bakar ZA, Ruzan IN
…ostic tools are critically needed to diagnose Mycobacterium tuberculosis and rifampicin resistance in AFB smear-negative samples. In this study, we evaluated the diagnostic performance of Xpert MTB/RIF Ultra (Ultra) as a rapid test to diagnose tuberculosis in smear-negative cases…
Chekesa B, Singh H, Gonzalez-Juarbe N, Vashee S, Wiscovitch-Russo R, et al.
Background The lineage 4 (L4) of Mycobacterium tuberculosis (MTB) is not only globally prevalent but also locally dominant, surpassing other lineages, with lineage 2 (L2) following in prevalence. Despite its widespread occurrence, factors influencing the expansion of L4 and its s…