Showing 51–75 of 200 documents
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Bamidele J, Abiodun O, Sodeinde K, Daniel O
Background Tuberculosis is still a major public health concern that affects millions of people worldwide. Despite the fact that tuberculosis has a well-established treatment, little attention is paid to the quality of life of TB patients on treatment. Poor quality of life has bee…
Chidambaram V, Tun NL, Majella MG, Ruelas Castillo J, Ayeh SK, et al.
Background Although the incidence of tuberculosis is higher in men than in women, the relationship of sex with tuberculosis treatment outcomes has not been adequately studied. Methods We performed a retrospective cohort study and a systematic review and meta-analysis of observati…
Musisi E, Dide-Agossou C, Al Mubarak R, Rossmassler K, Ssesolo AW, et al.
… need for improved pharmacodynamic markers for use in human tuberculosis (TB) drug trials. Pharmacodynamic monitoring in TB has conventionally used culture or molecular methods to enumerate the burden of Mycobacterium tuberculosis organisms in sputum. A recently proposed assay ca…
Peetluk LS, Rebeiro PF, Cordeiro-Santos M, Kritski A, Andrade BB, et al.
Background Weight change may inform tuberculosis treatment response, but its predictive power may be confounded by human immunodeficiency virus (HIV). Methods We prospectively followed up adults with culture-confirmed, drug-susceptible, pulmonary tuberculosis receiving standard 4…
Dooley KE, Kaplan R, Mwelase N, Grinsztejn B, Ticona E, et al.
Background The concurrent treatment of tuberculosis and human immunodeficiency virus (HIV) is challenging, owing to drug interactions, overlapping toxicities, and immune reconstitution inflammatory syndrome (IRIS). The efficacy and safety of dolutegravir (DTG) were assessed in ad…
Yun YJ, Lee JS, Yoo JC, Cho E, Park D, et al.
…gs used in combination chemotherapies against Mycobacterium tuberculosis, and its use has greatly shortened the duration of chemotherapy for the successful treatment of drug-susceptible tuberculosis. Compensatory mutations have been identified in rpoC that restore the fitness of …
Chabala C, Turkova A, Thomason MJ, Wobudeya E, Hissar S, et al.
Background Tuberculosis (TB) in children is frequently paucibacillary and non-severe forms of pulmonary TB are common. Evidence for tuberculosis treatment in children is largely extrapolated from adult studies. Trials in adults with smear-negative tuberculosis suggest that treatm…
Ko EM, Min J, Kim H, Jeong JA, Lee S, et al.
…anscriptomic analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with drug-susceptible tuberculosis (DS-TB). The clinical isolates were categorized based on treatment duration: standard 6 months or >6 months. Methods Study participants were recruit…
Shurygina AS, Zabolotnykh NV, Vinogradova TI, Vitovskaya ML, Dogonadze MZ, et al.
The steady rise of drug-resistant tuberculosis (TB), which renders standard therapy regimens ineffective, necessitates the development of innovative treatment approaches. Immunotherapeutic vaccines have the potential to effectively regulate the anti-TB immune response and enhance…
Sebastian J, Thomas A, Levine C, Shrestha R, Levy S, et al.
Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease, suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting Mycobacterium tuberculosis population.…
Radtke KK, Dooley KE, Dodd PJ, Garcia-Prats AJ, McKenna L, et al.
…ng children are particularly susceptible to severe forms of tuberculosis and poor treatment response. WHO dosing guidelines for drugs for tuberculosis treatment are based only on weight, which might lead to systematic underdosing and poor outcomes in these children. We aimed to a…
Dorman SE, Nahid P, Kurbatova EV, Goldberg SV, Bozeman L, et al.
Introduction Phase 2 clinical trials of tuberculosis treatment have shown that once-daily regimens in which rifampin is replaced by high dose rifapentine have potent antimicrobial activity that may be sufficient to shorten overall treatment duration. Herein we describe the design…
Omollo C, Singh V, Kigondu E, Wasuna A, Agarwal P, et al.
Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic efficacy a…
Jumat MI, Jani J, Mustapha ZA, Rodrigues KF, Azizan N, et al.
…ist of small RNAs from three drug-susceptible Mycobacterium tuberculosis strains isolated from Sabah, Malaysia. Sputum samples were obtained from three tuberculosis patients belonging to different districts. The bacteria were detected using GeneXpert MTB/RIF, isolated and culture…
Goutelle S, Bahuaud O, Genestet C, Millet A, Parant F, et al.
… of RIF and 25-dRIF collected in adult patients treated for tuberculosis. Methods In adult patients receiving 10 mg/kg of RIF as part of a standard regimen for drug-susceptible pulmonary tuberculosis enrolled in the Opti-4TB study, plasma RIF and 25-dRIF concentrations were measu…
Dorman SE, Nahid P, Kurbatova EV, Phillips PPJ, Bryant K, et al.
… shorter course in patients with drug-susceptible pulmonary tuberculosis. Methods In an open-label, phase 3, randomized, controlled trial involving persons with newly diagnosed pulmonary tuberculosis from 13 countries, we compared two 4-month rifapentine-based regimens with a sta…
Dawson R, Diacon AH, De Jager V, Narunsky K, Moodley VM, et al.
…y in adults with smear-positive, drug-susceptible pulmonary tuberculosis. Stage 2 of this study was designed to evaluate the safety, tolerability, pharmacokinetics, and early bactericidal activity of quabodepistat in combination with delamanid, bedaquiline, or both versus rifampi…
Tanner L, Evans JC, Seldon R, Jordaan A, Warner DF, et al.
Mycobacterium tuberculosis , the causative agent of tuberculosis, remains a leading infectious killer globally, demanding the urgent development of faster-acting drugs with novel mechanisms of action. Riminophenazines such as clofazimine are clinically efficacious against both dr…
John Z Metcalfe, Isabelle R Weir, Kimberly K Scarsi, Alberto Mendoza-Ticona, Samuel Pierre, et al.
…ed with treatment shortening potential for drug-susceptible tuberculosis; the Clo-Fast trial aimed to determine the efficacy and safety of this regimen. We compared 3 months of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine, administered with a clofazimine load…
Pettit AC, Shepherd BE, Sterling TR
…cribes recent advances in the treatment of drug-susceptible tuberculosis (DS-TB) among people living with human immunodeficiency virus (PLWH). Recent findings Higher than standard rifampicin doses (>10 mg/kg/day) are well tolerated and have improved sterilizing activity. Standard…
Muhammad Dayyab F, Iliyasu G, Garba Ahmad B, Aliyu Umar I, Musa Shuaib N, et al.
Background Mycobacterium tuberculosis with resistance to first line and second line anti tuberculous drugs is a serious setback in the treatment of tuberculosis (TB). The COVID-19 pandemic constitutes a serious threat that could unwind the recent gains made thus far in the contro…
Bart G J Dekkers, Huib A M Kerstjens, Helene W Breisnes, Diana J Leeming, Richard M Anthony, et al.
… reduce excessive inflammation and prevent tissue damage in tuberculosis are being investigated. Macrolides, including azithromycin, were shown to possess anti-inflammatory and immune-modulatory effects in addition to their antibacterial effects. In the current trial, we investig…
Fry S, Barnabas S, Cotton MF
Purpose of review Although tuberculosis (TB) causes much morbidity and mortality in children, diagnosis and treatment remain challenging. Recently, children have gained increasing attention in research and clinical trials driving improved contact management, case identification a…
Lun S, Xiao S, Zhang W, Wang S, Gunosewoyo H, et al.
…se 13 (Pks13) is an important enzyme found in Mycobacterium tuberculosis ( M. tuberculosis ) that condenses two fatty acyl chains to produce α-alkyl β-ketoesters, which in turn serve as the precursors for the synthesis of mycolic acids that are essential building blocks for maint…
Workie MG, Aycheh MW, Birhanu MY, Tsegaye TB
Background Tuberculosis treatment interruption is a failure of attending two scheduled appointments to collect the drugs in either phase of tuberculosis treatment. Even if TB treatment is crucial to achieve a cure and avoid the emergence of drug resistance, treatment interruption…