Showing 51–75 of 200 documents
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Huang JH, Chen H, Zhang ZC, Gu J, Yan L, et al.
Background and objective Cancer ratio (CR), which is defined as serum lactate dehydrogenase (LDH) to pleural fluid adenosine deaminase (ADA) ratio, has been reported to be a useful diagnostic marker for malignant pleural effusion (MPE). Whether its diagnostic accuracy is affected…
Raizada N, Khaparde SD, Swaminathan S, Sarin S, Salhotra VS, et al.
…te of the increasing availability of rapid high-sensitivity diagnostics in public and private sectors, majority of paediatric TB cases are empirically diagnosed, without laboratory confirmation. To address these diagnostic challenges, World Health Organization (WHO) has recommend…
Zou X, Zhu Y, Hu Q, Qi Q, Hua H, et al.
Background To investigate the diagnostic value of bronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) in tuberculous peripheral pulmonary lesions. Methods A total of 770 patients who completed CT imaging and ultrasound bronchoscopy were retrospectively analyzed. Al…
Ibrahim Adamu, Nura Umaru, Adamu Mohammed Sani, Ali Adamu Abdullahi, Jabir Hamza Adamu, et al.
**PURPOSE:** Pulmonary tuberculosis (PTB) continues to be a major public health burden, a situation exacerbated by significant diagnostic gaps. Conventional testing relies heavily on sputum samples, but many patients are unable to produce adequate and qualitative sputum. This lim…
Ismail IM, Kibballi Madhukeshwar A, Naik PR, Nayarmoole BM, Satyanarayana S
Background In India, ensuring all Persons with Presumptive TB (PPTB) undergo TB diagnostic tests and initiating all diagnosed TB patients on treatment are two major implementation challenges. Objectives In a coastal district of Karnataka state, South India, to (1) determine the n…
Rahma Isti Kusyadi, Lita Diah Rahmawati, Prastuti Asta Wulaningrum
**INTRODUCTION:** Poncet's disease (PD) is a rare form of TB-associated reactive arthritis, presents a major diagnostic challenge due to its close resemblance to rheumatoid arthritis and tuberculous septic arthritis. A clear diagnostic workflow is essential to support clinical de…
Holtgrewe LML, Jain S, Dekova R, Broger T, Isaacs C, et al.
Rapid and accurate point-of-care (POC) tuberculosis (TB) diagnostics are crucial to bridge the TB diagnostic gap. Leveraging recent advancements in COVID-19 diagnostics, we explored adapting commercially available POC SARS-CoV-2 tests for TB diagnosis in line with the World Healt…
Halliday A, Jain P, Hoang L, Parker R, Tolosa-Wright M, et al.
Background Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed. Objective To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain re…
Khalid Alyahyawi
…opic features, histopathological characteristics, molecular diagnostics, pharmacological therapy, and minimally invasive therapeutic interventions. Accurate diagnosis requires an integrated approach combining clinical assessment with imaging, endoscopic evaluation, and histopatho…
Yating Zhao, Longting Du, Junli Song, Wei Sun, Yili Chen, et al.
…Our findings provide actionable solutions for optimizing TB diagnostics in diverse healthcare ecosystems, aligning with the WHO's End TB Strategy to ensure equitable access to rapid diagnostics.
Jorge E Leiva-Ordoñez, Beatriz Quintero
Tuberculous meningitis is the most severe form of tuberculosis and remains associated with high mortality and substantial neurological disability, particularly among children and people living with HIV. Early diagnosis is challenging because of nonspecific clinical manifestations…
Padingani M, Kumar A, Tripathy JP, Masuka N, Khumalo S
Introduction While there are many studies assessing the pre-treatment loss to follow-up (LFU) among tuberculosis patients in public sector, there is no evidence from private-for-profit health sector and pre-diagnostic LFU from Zimbabwe. We aimed to assess the gaps in the cascade …
Nichols BE, de Nooy A, Cassim N, Hans L, da Silva MP, et al.
Introduction To ensure there is adequate investment into diagnostics, an understanding of the magnitude of impact and return on investment is necessary. We, therefore, sought to understand the health and economic impacts of the molecular diagnostic programme in South Africa, to d…
Suneja M, Beekmann SE, Dhaliwal G, Miller AC, Polgreen PM
Objectives Diagnostic delays are a major source of morbidity and mortality. Despite the adverse outcomes associated with diagnostic delays, few studies have examined the incidence and factors that influence diagnostic delays for different infectious diseases. The objective of thi…
Meryem Sena Kaya, Sibel Yıldız Kaya, Rıdvan Karaali, Günay Can, İlker İnanç Balkan, et al.
**BACKGROUND:** Fever of unknown origin (FUO) remains a significant diagnostic challenge. Changes in patient populations and diagnostic technologies may shift the spectrum of underlying etiologies. This study aimed to examine recent FUO cases at a single tertiary center to identi…
Liu XT, Dong XL, Zhang Y, Fang P, Shi HY, et al.
Background Pleural effusions occur for various reasons, and their diagnosis remains challenging despite the availability of different diagnostic modalities. Medical thoracoscopy (MT) can be used for both diagnostic and therapeutic purposes, especially in patients with undiagnosed…
Yan Z, Wen JX, Wang H, Jiang TW, Huang JH, et al.
Background This study aimed to evaluate the diagnostic accuracy of pleural fluid (PF) lactate dehydrogenase (LDH) to adenosine deaminase (ADA) (LDH/ADA) ratio for tuberculous pleural effusion (TPE). Especially to explore whether the LDH/ADA ratio provides added diagnostic value t…
Tan Kah Shien, Mas Fazlin Mohamad Jailaini, Azat Azrai Azmel, Vijayan Munusamy, Arvindran Alaga, et al.
**BACKGROUND:** Tuberculous pleural effusion (TPE) remains a diagnostic challenge, particularly in tuberculosis-endemic regions. Pleural fluid adenosine deaminase (pfADA) is widely used as a diagnostic biomarker; however, its optimal cutoff value may vary depending on the epidemi…
Zou X, Xu H, Hu Q, Qi Q, Ma X, et al.
Background Microbiological diagnosis of pulmonary tuberculosis (PTB) is hampered by a low pathogen burden, low compliance and unreliable sputum sampling. Although endobronchial ultrasound-guided transbronchoscopic lung biopsy (EBUS-TBLB) has been found to be useful for the assess…
Zhang M, Li D, Hu ZD, Huang YL
Tuberculosis pleural effusion (TPE) is common in clinical practice, and its diagnosis remains a challenge for clinicians. Ziehl-Neelsen staining, PE Mycobacterium tuberculosis culture, and biopsy are the gold standards for TPE diagnosis; however, they are time-consuming, invasive…
Peng L, Ma W, Zhong L, Yang J, Wu H, et al.
The aim of this study was to evaluate the diagnostic accuracy of the IGRA, TST, and TBST by combining diagnostic test accuracy (DTA) analysis and network meta-analysis (NMA) to increase the reliability and accuracy of diagnostic methods and promote the eradication of TB. An elect…
Srivastava S, Singh PK, Vatsalya V, Karch RC
Objectives Diagnostics is the first step for the treatment and eradication of infectious microbial diseases. Due to ever evolving pathogens and emerging new diseases, there is an urgent need to identify suitable diagnostic techniques for better management of each disease. The suc…
Miller AC, Arakkal AT, Koeneman SH, Cavanaugh JE, Polgreen PM
Objectives A first step in studying diagnostic delays is to select the signs, symptoms and alternative diseases that represent missed diagnostic opportunities. Because this step is labor intensive requiring exhaustive literature reviews, we developed machine learning approaches t…
Ntinginya NE, Kuchaka D, Orina F, Mwebaza I, Liyoyo A, et al.
…portunities to maximise uptake and utilisation of molecular diagnostics in routine healthcare settings. Methods Using the implementation of WHO approved TB diagnostics, Xpert Mycobacterium tuberculosis /rifampicin (MTB/RIF) and Line Probe Assay (LPA) as a benchmark, we evaluated …
Yifan Tang, Cheng Chen, Mingming Chen, Kai Wang, Sifan Wang, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major public health concern. Despite improved diagnostic tools, delays in TB diagnosis persist and hinder control efforts. **OBJECTIVE:** This study aims to investigate the spatiotemporal patterns of TB diagnostic delay and identify in…