Showing 51–75 of 200 documents
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Osei-Wusu S, Amo Omari M, Asante-Poku A, Darko Otchere I, Asare P, et al.
Background Drug resistance surveillance is crucial for tuberculosis (TB) control. Therefore, our goal was to determine the prevalence of second-line anti-TB drug resistance among diverse primary drug-resistant Mycobacterium tuberculosis complex (MTBC) isolates in Ghana. Materials…
Cui ZJ, Zhang WT, Zhu Q, Zhang QY, Zhang HY
…vaccines, TB has again become a threat because of increased drug resistance. There is still a lack of effective treatment regimens for a person who is already infected with multidrug-resistant Mtb (MDR-Mtb) or extensively drug-resistant Mtb (XDRMtb). In the past decades, many res…
Kidenya BR, Mshana SE, Fitzgerald DW, Ocheretina O
Background Drug resistant Tuberculosis (TB) is considered a global public health threat. Whole-genome sequencing (WGS) is a new technology for tuberculosis (TB) diagnostics and is capable of providing rapid drug resistance profiles and genotypes for epidemiologic surveillance. Th…
Hira Ashfaq, Ayesha Humayun, Muhammad Ahmad Naseem, Sarmad Wahaj Siddiqui, Asifa Kamal, et al.
**BACKGROUND:** Globally, the prevalence of drug-resistant (DR-TB) tuberculosis is rising, and Pakistan is currently one of the nations with the highest burden. It is imperative to track changes in the prevalence of DR-TB, particularly the extensively drug-resistant (XDR-TB) tube…
Sharma AK, Gupta N, Kala DK, Patni T, Dixit R, et al.
…s and objectives To determine the prevalence and pattern of resistance to second line drugs among multi drug resistant (MDR) tuberculosis patients being treated on category IV regimen. Methodology This study was conducted at Department of Respiratory Medicine, J.L.N. Medical Coll…
Mizukoshi F, Kobayashi N, Kirikae F, Ohta K, Tsuyuguchi K, et al.
Clinical isolates of drug-resistant (isoniazid and/or rifampicin-resistant) Mycobacterium tuberculosis were obtained from 254 patients diagnosed with drug-resistant tuberculosis in Japan from April 2015 to March 2017 in National Hospital Organization hospitals. The 254 patients w…
Jin C, Wu Y, Chen J, Liu J, Zhang H, et al.
…ence of resistant Mycobacterium tuberculosis (MTB) strains. Drug-resistant TB, including mono-drug-resistant TB, multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB), presents significant public health challenges. Methods We conducted a systematic literatur…
Li M, Deng B, Huang Y, Li Q, Han J, et al.
To investigate the status of the drug-resistant tuberculosis (DR-TB) among children in Sichuan, and to find out the risk factors and high-risk population related to drug resistance among children. The clinical data of tuberculosis patients ≤14 years old with culture-confirmed tub…
Chawla GK, Garg K, Kaur K, Chopra V, Suri R
Background Drug resistant tuberculosis (DR-TB), particularly multidrug resistance (MDR-TB) and extensive drug resistance (XDR-TB) pose a serious threat to public health. This study aimed to identify drug resistance in pulmonary tuberculosis patients and to see their association w…
Getu Diriba, Hilina Mollalign, Abyot Meaza, Melak Getu, Betselot Zerihun, et al.
**BACKGROUND:** Rapid and accurate detection of extensively drug-resistant tuberculosis is crucial for effective intervention. Next-generation sequencing technologies have been recommended to rapidly and accurately detect resistance to second-line anti-TB drugs. We deployed whole…
Garg RK, Rizvi I, Malhotra HS, Uniyal R, Kumar N
Introduction Drug-resistant tuberculous meningitis has been reported worldwide. Isoniazid mono-resistance is the most frequent cause of drug-resistant tuberculous meningitis, a life-threatening disease. Extensive drug-resistant tuberculous meningitis has also been reported in som…
Suman SK, Chandrasekaran N, Priya Doss CG
…b ) and has become increasingly challenging to treat due to drug resistance. The World Health Organization declared TB a global health emergency in 1993. Drug resistance in TB is driven by mutations in the bacterial genome that can be influenced by prolonged drug exposure and poo…
Yenew B, Kebede A, Alemu A, Diriba G, Mehammed Z, et al.
Background The emergence of drug-resistant tuberculosis (DR-TB) has been a major obstacle to global tuberculosis control programs, especially in developing countries, including Ethiopia. This study investigated drug resistance patterns and associated mutations of Mycobacterium tu…
Hailemariam TG, Ayele A, Gelanew T, Atnafu A, Brennan M, et al.
…jor global health challenge, particularly due to increasing drug resistance. Beyond the well-characterized mutations, the mechanisms involved in driving resistance appear to be more complex. This study investigated the differential gene expression of Ethiopian drug-resistant Mtb …
Liu D, Huang F, Zhang G, He W, Ou X, et al.
Objectives Phenotypic drug susceptibility testing for prediction of tuberculosis (TB) drug resistance is slow and unreliable, limiting individualized therapy and monitoring of national TB data. Our study evaluated whole-genome sequencing (WGS) for its predictive accuracy, use in …
Chen S, Shang Y, Zheng J, Huo F, Xue Y, et al.
Objectives The co-resistance between bedaquiline and clofazimine raises significant concerns, as they are commonly co-administered as core drugs in drug-resistant TB regimens. The present study aimed to monitor drug resistance-associated gene mutations and the phenotypic change i…
O'Toole RF
…demic has had on the control of tuberculosis (TB) including drug-resistant forms of the disease. Antimicrobial resistance increases the likelihood of worsened outcomes in TB patients including treatment failure and death. Multidrug-resistant (MDR) strains, resistant to first-line…
Chen X, He G, Wang S, Lin S, Chen J, et al.
…lly feasible tool for timely and comprehensive diagnosis of drug resistance in developed countries. With the increase in the incidence of multidrug-resistant tuberculosis (MDR-TB), second-line anti-TB drugs are gaining importance. However, genetic resistance to second-line anti-T…
Khawbung JL, Nath D, Chakraborty S
… tuberculosis continuously evolved to resist the antagonist drugs. This has led to the outbreak of resistant strain that gave rise to "Multi Drug Resistant-Tuberculosis" and "Extensively Drug Resistant Tuberculosis" that can still be cured with a lower success rate. While the mec…
Zeng X, Kwok JS, Yang KY, Leung KS, Shi M, et al.
Background Drug resistance in Mycobacterium tuberculosis (MTB) is one of the major challenges in tuberculosis (TB) treatment. However, known mutations cannot explain all of the cases of resistance and little research has focused on the relationship between insertions / deletions …
Sarwer MI, Khan MT, Khurshid S
Introduction Phenotypic drug susceptibility testing is the most common approach to assess drug-resistant isolates; however, molecular methods of drug susceptibility testing are fast, accurate hence, offer less time for transmission during the diagnosis period. As data on the mole…
Liu L, Zhao X, Wu X, Li S, Liu B, et al.
Background The emergence of antimicrobial resistance against Mycobacterium tuberculosis (M. tuberculosis) has become the major concern in global tuberculosis control due to its limited therapy options and high mortality. However, the clinical and molecular characteristics of drug…
Nimmo C, Millard J, Faulkner V, Monteserin J, Pugh H, et al.
Mycobacterium tuberculosis has acquired drug resistance to all drugs that have been used against it, including those only recently introduced into clinical practice. Compared to other bacteria, it has a well conserved genome due to its role as an obligate human pathogen that has …
Maeda T, Kawada M, Sakata N, Kotani H, Furusawa C
Drug-resistant tuberculosis (TB) is a growing public health problem. There is an urgent need for information regarding cross-resistance and collateral sensitivity relationships among drugs and the genetic determinants of anti-TB drug resistance for developing strategies to suppre…
Eoh H, Liu R, Lim J, Lee JJ, Sell P
…r non-replicating and lacking a stably heritable antibiotic resistance, termed drug tolerance). The formation of drug-tolerant Mtb persisters is associated with TB treatment failure and is thought to be an adaptive strategy for eventual development of permanent genetic mutation-m…