Showing 26–50 of 200 documents
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Rollo RF, Mori G, Hill TA, Hillemann D, Niemann S, et al.
…urgent priorities for reducing the immense global burden of tuberculosis (TB). As treatment of TB currently requires multiple antibiotics with diverse mechanisms of action, any new drug lead requires assessment of potential interactions with existing TB antibiotics. We previously…
Chand AB, Basnet A, Maharjan B, Rai G, Joshi YP, et al.
Background Multidrug-resistant tuberculosis (MDR-TB), characterized by isoniazid and rifampicin resistance, is caused by chromosomal mutations that restrict treatment options and complicate tuberculosis management. This study sought to investigate the prevalence of pre-extensivel…
Zhang Z, Cheng Z, Liu Q, Shang T, Jiang L, et al.
…as a Group A agent for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in longer regimens (18-20 months). However, little is known about the safety of LNZ in longer TB treatment regimens in children. Methods Here we …
Hegeto LA, Caleffi-Ferracioli KR, Nakamura-Vasconcelos SS, Almeida AL, Baldin VP, et al.
Tuberculosis (TB) is an important public health problem worldwide and the emergence of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB worsened the global context. The resistance in Mycobacterium tuberculosis, the causative agent of TB, can partially derive f…
Diriba G, Kebede A, Tola HH, Yenew B, Moga S, et al.
Background Molecular characterization of Mycobacterium tuberculosis (MTB) is important to understand the pathogenesis, diagnosis, treatment, and prevention of tuberculosis (TB). However, there is limited information on molecular characteristics and drug-resistant patterns of MTB …
Verma AK, Yadav RN, Kumar G, Dewan RK
Objective This study aimed to analyze the trends of tuberculosis (TB) disease, drugs susceptibility patterns in geriatric TB over a period of three years (from 2010 to 2012). Materials & methods In this study, laboratory data on diagnosis of geriatric tuberculosis suspected patie…
Starshinova A, Dovgalyk I, Belyaeva E, Glushkova A, Osipov N, et al.
… continued growth of multiple- and extensive drug-resistant tuberculosis, use of the new highly effective anti-tuberculosis drugs in this patient category is of great relevance. The aim of the study was determination the efficacy of treatment in patients with multidrug- and exten…
Diriba G, Alemu A, Tola HH, Yenew B, Amare M, et al.
Background The rise of drug-resistant tuberculosis (DR-TB) has presented a substantial challenge to the national tuberculosis (TB) control program. Understanding the epidemiology of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) could help clinicians to adapt MDR-TB tre…
Li H, Yuan J, Duan S, Pang Y
Tuberculosis (TB) poses a serious threat to public health worldwide since it was discovered. Until now, TB has been one of the top 10 causes of death from a single infectious disease globally. The treatment of active TB cases majorly relies on various anti-tuberculosis drugs. How…
Jan F, Wali S, Sadia S, Akbar MT, Akbar HS, et al.
…as been rapidly spreading in recent years. In new pulmonary tuberculosis patients, rapid spread of MDR-TB and XDR-TB challenging the effectiveness of national TB control programs especially in many low-income countries. This study was aimed to determine the resistance pattern of …
Mercier T, Desfontaine V, Cruchon S, Da Silva Pereira Clara JA, Briki M, et al.
Objective Anti-tuberculosis (antiTB) drugs are characterized by an important inter-interindividual pharmacokinetic variability poorly predictable from individual patients' characteristics. Therapeutic drug monitoring (TDM) may therefore be beneficial for patients with Mycobacteri…
Mokrousov I, Vyazovaya A, Levina K, Gerasimova A, Zhuravlev V, et al.
…h control programmes influence the spread of drug-resistant tuberculosis (TB). We analysed the Mycobacterium tuberculosis population structure in Estonia, a high-priority EU country for TB control, to detect the dynamic changes and underlying factors. The study collection include…
Alberto Matteelli, Sofia Lovatti, Benedetta Rossi, Luca Rossi
Multidrug-resistant tuberculosis (MDR-TB), the deadliest form of tuberculosis (TB), has been included in the 2024 World Health Organization (WHO) priority list of antibiotic-resistant bacterial pathogens owing to its severe public health implications. Almost two billion people wo…
Kunping Cui, Xiaoxiao Zhao, Wei Liu, Lang Bai
**BACKGROUND:** Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) among those aged 15-49 years pose a severe public health challenge, yet our understanding of the burden of these diseases in this age group remains limited. This study a…
Kashish Choudhary, Sana Tanweer, Mohd Zaid Choudhary, Sonam Grover
Tuberculosis (TB) is a health concern resulting in 10.8 million cases every year. In 2024, TB had the highest fatalities second only to COVID-19. Global TB management has become difficult due to rise of multi-drug resistant (MDR) and extensively drug-resistant (XDR) TB. Therefore…
Ohji R, Shinohara T, Ohji H, Hatakeyama N, Iwamura S, et al.
Drug-susceptibility test (DST) is important for tuberculosis care; however, there are several pitfalls with the procedure. A 70-year-old woman was diagnosed with extensively drug-resistant tuberculosis based on the result of a DST using microdilution method. Because she had no hi…
Chizimu JY, Solo ES, Bwalya P, Kapalamula TF, Mwale KK, et al.
The emergence of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) is a threat to TB control programs in developing countries such as Zambia. Studies in Zambia have applied molecular techniques to understand drug-resistance-associated mutations, circulating lineages and tr…
Mancuso G, Midiri A, De Gaetano S, Ponzo E, Biondo C
…in disease management. Mismanagement of multidrug-resistant tuberculosis (MDR-TB) cases, resulting from intermittent drug use, prescription errors, and non-compliance of patients, has been identified as a critical risk factor for the development of extensively drug-resistant tube…
Sheng-Nan Tang, Xi-Ling Huang, Alena Skrahina, Qiu-Ting Zheng, Aleh Tarasau, et al.
…eful in differentiating multidrug-resistant (MDR) pulmonary tuberculosis (PTB) from drug-sensitive (DS) tuberculosis (TB) on chest computed tomography (CT). This study aims to confirm the difference in PN features between DS and MDR patients. **METHODS:** Eastern European (Belar…
The WHO Consolidated Guidelines on Tuberculosis (TB), Module 4: Treatment - Drug-Resistant Tuberculosis Treatment 2022 update informs health care professionals in Member States on how to improve treatment and care for patients with drug-resistant TB (DR-TB). This document include…
Monde N, Munyeme M, Chongwe G, Wensman JJ, Zulu M, et al.
Background Drug-resistant tuberculosis has continued to be a serious global health threat defined by complexity as well as higher morbidity and mortality wherever it occurs, Zambia included. However, the paucity of information on drug-susceptibility patterns of both first-line an…
Sonnenkalb L, Strohe G, Dreyer V, Andres S, Hillemann D, et al.
…tment failure of multi/extensively drug resistant (MDR/XDR) tuberculosis (TB). Intrapatient evolutionary dynamics of Mycobacterium tuberculosis complex (Mtbc) strains and their implications on treatment outcomes are still not completely understood. To elucidate how Mtbc strains e…
Dreyer V, Mandal A, Dev P, Merker M, Barilar I, et al.
Background Multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) strains are a serious health problem in India, also contributing to one-fourth of the global MDR tuberculosis (TB) burden. About 36% of the MDR MTBC strains are reported fluoroquinolone (FQ) resistant …
Diriba G, Alemu A, Yenew B, Tola HH, Gamtesa DF, et al.
…stimate the pooled proportion of extensively drug-resistant tuberculosis (XDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) in patients with multidrug-resistant TB (MDR-TB). Methods We systematically searched articles from electronic databases: MEDLINE (PubMed)…
Trisakul K, Nonghanphithak D, Chaiyachat P, Kaewprasert O, Sakmongkoljit K, et al.
Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) make TB difficult to control. Global susceptibility data for six newly recommended anti-TB drugs against M/XDR-TB are still limited. Using publicly available whole-genome sequences, we …