Showing 26–50 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Oo MM, Tassanakijpanich N, Phyu MH, Safira N, Kandel S, et al.
Background The comorbid presence of tuberculosis and diabetes mellitus has become an increasingly important public health threat to the prevention and control of both diseases. Thus, household contact investigation may serve a dual purpose of screening for both tuberculosis and d…
Alrajhi AA, Alotaibi J, Alghamdi AM, Almanea H, AlSebayel M, et al.
Objectives Mycobacterium tuberculosis DNA has been detected in multiple organs in people without active tuberculosis or a history of tuberculosis. Molecular testing for metabolic activity has suggested that M tuberculosis DNA represents viable bacilli. Whether transplanted organs…
Onah CK, Azuogu BN, Ossai EN, Agu AP, Azuogu VC, et al.
Background A major constraint to tuberculosis control is low case finding with under-reporting to national authorities. Evidence shows that Patent Medicine Dealers are first port of call for most people with symptoms of tuberculosis, yet there is poor referral of such clients to …
Chen J, Xu Z, Xu H, Bai L
Objectives Reducing mortality during anti-tuberculosis treatment is crucial for completing full-course standardized therapy and achieving tuberculosis cure. The study aims to analyze the mortality and its influencing factors among pulmonary tuberculosis patients undergoing anti-t…
Hao X, Bai J, Ding Y, Wang J, Liu Y, et al.
…ty of traditional etiological methods to diagnose pulmonary tuberculosis rapidly and effectively, the antibody responses against 38kD and 16kD-antigens of Mycobacterium tuberculosis ( M. tuberculosis ) were both detected in order to obtain a better serological detection method fo…
Gemechu Gelana Ararame, Birbirsa Sefera Senbeta, Tesfaye Negesa Liche, Elias Zewdu Sileshi
Comorbid diseases are complex diseases associated with tuberculosis that may affect tuberculosis treatment outcomes and mortality. The impact of comorbid diseases on tuberculosis treatment outcomes and mortality is not well known in Ethiopia. To assess the impact of comorbid dise…
Menzies NA, Swartwood NA, Cohen T, Marks SM, Maloney SA, et al.
Background For settings with low tuberculosis incidence, disease elimination is a long-term goal. We investigated pathways to tuberculosis pre-elimination (incidence Methods Using a mathematical modelling framework, we simulated how US tuberculosis incidence could be affected by …
Meier NR, Sutter TM, Jacobsen M, Ottenhoff THM, Vogt JE, et al.
Rationale Tuberculosis diagnosis in children remains challenging. Microbiological confirmation of tuberculosis disease is often lacking, and standard immunodiagnostic including the tuberculin skin test and interferon- γ release assay for tuberculosis infection has limited sensiti…
Reichler MR, Khan A, Sterling TR, Zhao H, Moran J, et al.
Background The risk and timing of tuberculosis among recently exposed close contacts of patients with infectious tuberculosis are not well established. Methods We prospectively enrolled patients ≥15 years of age with culture-confirmed pulmonary tuberculosis and their close contac…
Chiang SS, Murray MB, Kay AW, Dodd PJ
Introduction During adolescence, tuberculosis incidence rises, with a greater increase in males compared with females. Tuberculosis notifications and estimates infrequently disaggregate adolescent age groups. Moreover, the factors that drive the increases in overall incidence and…
Pinto PFPS, Teixeira CSS, Ichihara MY, Rasella D, Nery JS, et al.
Background Although household contacts of patients with tuberculosis are known to be particularly vulnerable to tuberculosis, the published evidence focused on this group at high risk within the low-income and middle-income country context remains sparse. Using nationwide data fr…
Silva S, Arinaminpathy N, Atun R, Goosby E, Reid M
Background The tuberculosis targets for the UN Sustainable Development Goals (SDGs) call for a 90% reduction in tuberculosis deaths by 2030, compared with 2015, but meeting this target now seems highly improbable. To assess the economic impact of not meeting the target until 2045…
Daniel W, Tadesse S, Tamirat T, Selamu M
Background The risk of tuberculosis transmission is higher among household contacts than the general population. However, there is a paucity of information that explains the risk of experiencing active tuberculosis among household contacts in countries with a high burden of tuber…
Jia Q, Masleša-Galić S, Nava S, Horwitz MA
Mycobacterium tuberculosis infects approximately one-third of the world's population, causing active tuberculosis (TB) in ~10 million people and death in ~1.5 million people annually. A potent vaccine is needed to boost the level of immunity conferred by the current Mycobacterium…
Bi D, Liang C, Huang X, Pan H, Qin Y, et al.
…ility of commercially available antibodies of Mycobacterium tuberculosis in the diagnostic assessment of suspected tuberculosis in high-burden countries. Methods We conducted a retrospective, descriptive, cohort study among participants aged ≥ 18 years with suspected tuberculosis…
Steven G Smith, Ruth Bowness, Jacqueline M Cliff
Host-directed therapy could potentially revolutionize tuberculosis control as an adjunct to traditional antibiotics for the treatment of tuberculosis disease and as a strategy to prevent disease progression following Mycobacterium tuberculosis infection. The growing type 2 diabet…
Meiwes L, Kontsevaya I, Chesov D, Kulciţkaia S, Dreyer V, et al.
…ce mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with tuberculosis. To date, no study has evaluated the use of FMS to detect pulmonary tuberculosis in children. We developed a method for FMS of M. tuberculosis-specific DNA…
Shivangi Sinhal, Geetika Srivastava, Shrish Bhatnagar, Nanda Chhavi, Digvijay Chaudhary, et al.
…ection is highly prevalent in our country and conversion to tuberculosis disease is a major concern. Under the National Strategic Plan, India is heading towards ending tuberculosis by 2025. The benefits of tuberculosis preventive therapy are being extended to the children aged &#…
Pelzer PT, Stuck L, Martinez L, Richards AS, Acuña-Villaorduña C, et al.
Background Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the protection against disease would accelerate tuberculosis vaccine development. We aimed to assess whether the effectivenes…
Honjo K, Komiya K, Kan T, Uchida S, Goto A, et al.
…e advanced age is a main prognostic factor in patients with tuberculosis, the factors that specifically affect tuberculosis-related death are unclear because elderly people are at a risk for other age-related lethal diseases. We aimed to assess the impact of performance status on…
Seid G, Alemu A, Dagne B, Sinshaw W, Gumi B
Background The Mycobacterium tuberculosis complex causes tuberculosis, a severe public health problem. Close contacts of someone who has active pulmonary tuberculosis were at a greater risk of contracting the disease. Despite the large number of primary research available in Sub-…
Leyla Larsson, Ioana Diana Olaru, Anna-Lisa Behnke, Edson T Marambire, Martha Chipinduro, et al.
**BACKGROUND:** Tuberculosis elimination is constrained by symptom-based and sputum-dependent diagnostic strategies, which miss asymptomatic disease and are difficult to deploy in community settings. Household contacts of people with tuberculosis are a priority population for scr…
Hyun J, Lee M, Jung I, Kim E, Hahn SM, et al.
…cipients are immunocompromised and vulnerable to developing tuberculosis. However, active tuberculosis incidence is rapidly declining in South Korea, but the trend of tuberculosis infection among transplant recipients has not been elucidated. This study aimed to evaluate the risk…
Adane A, Damena M, Weldegebreal F, Mohammed H
Background Tuberculosis is an infectious airborne disease caused by Mycobacterium tuberculosis . It still remains a major public health problem which affects all age groups. Risk of exposure is higher in household contact than members of the general population. Objective The aim …
Liu L, Wang X, Luo L, Liu X, Chen J
Background Tuberculosis destroyed lung constitutes a significant worldwide public health challenge, little is known about its associated risk factors and prognosis. Our study aimed to identify the risk factors of tuberculosis destroyed lung among pulmonary tuberculosis and struct…