Showing 26–50 of 51 documents
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Ushtanit A, Kulagina E, Mikhailova Y, Makarova M, Safonova S, et al.
…n group C of the WHO recommended drugs for the treatment of tuberculosis resistant to rifampicin and multidrug-resistant tuberculosis. The clinical relevance of ethionamide and prothionamide has increased with the wide spread of resistant tuberculosis. Methods We retrospectively …
San LL, Aye KS, Oo NAT, Shwe MM, Fukushima Y, et al.
Objectives Myanmar is a World Health Organization high tuberculosis (TB) burden country with a high multidrug-resistant (MDR)-TB burden. Of significance, a high prevalence of the Beijing genotype of Mycobacterium tuberculosis (MTB) among MDR-MTB has been reported previously. A de…
Schami A, Islam MN, Wall M, Hicks A, Meredith R, et al.
…ecent decades, drug resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), have emerged that threaten public health. Although M.tb's complex and protective cell envelope has been widely studied, little is known about how levels of peripheral …
Kardan-Yamchi J, Amini S, Hamzelou G, Rahimi Foroushani A, Ghodousi A, et al.
…l VER 2.0 was used to detect resistance to second-line anti-tuberculosis drugs on 35 rifampicin-resistant M. tuberculosis (RR-MTB) isolates compared to the minimum inhibitory concentrations (MICs) and whole genome sequencing (WGS). The MTBDRsl VER 2.0 (Hain Life Science, Nehren, …
Che Y, Bo D, Lin X, Chen T, He T, et al.
…Detection of pyrazinamide (PZA) resistance in Mycobacterium tuberculosis (TB) patients is critical, especially in dealing with multidrug-resistant Mycobacterium tuberculosis (MDR-TB) case. Up to date, PZA drug susceptibility testing (DST) has not been regularly performed in China…
Greif G, Coithino C, Bentancor MN, Robello C
…nome sequencing (WGS) is sensitive tool for the analysis of tuberculosis transmission and drug-resistance. We used WGS to analyze the Mycobacterium tuberculosis evolution from isoniazid monoresistance to MDR/preXDR during a prolonged household outbreak. The outbreak started with …
Mogashoa T, Loubser J, Choga OT, Ngom JT, Choga WT, et al.
Background The emergence of drug-resistant Mycobacterium tuberculosis ( M. tb ) strains remains a threat to tuberculosis (TB) prevention and care. Understanding the drug resistance profiles of circulating strains is crucial for effective TB control. This study aimed to describe t…
Jantarabenjakul W, Supradish Na Ayudhya P, Suntarattiwong P, Thepnarong N, Rotcheewaphan S, et al.
Background The prevalence of drug-resistant tuberculosis (DR-TB) in adults has stabilized in the past decade. Our study aimed to describe the prevalence of DR-TB in Thai children between 2006 and 2021. Materials and methods Children younger than 15 years old who had culture-confi…
Hameed HMA, Tan Y, Islam MM, Guo L, Chhotaray C, et al.
…) are the cornerstones for treatment of multidrug-resistant tuberculosis (MDR-TB). China is one of the highest MDR- and fluoroquinolones (FQ)-resistant TB burdens countries. DNA gyrase encoded by gyr genes is the main target of FQ in Mycobacterium tuberculosis (MTB). The prevalen…
Bouziane F, Allem R, Sebaihia M, Kumanski S, Mougari F, et al.
…se the genotypes of multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) isolated in Algeria, where there is a low MDR-MTB incidence rate. Methods Ten MDR isolates and one resistant to isoniazid were investigated by PCR-Sanger sequencing for 10 loci involved in resistance. …
Rupasinghe P, Vereecken J, Graulus P, Decroo T, Ardizzoni E, et al.
…ing media, remains a challenge for fastidious Mycobacterium tuberculosis complex (MTBc) isolates due to insufficient growth on the growth controls (GC). Middlebrook 7H11 (M7H11) medium contains casein hydrolysate, which may favor the growth of such strains. Method In this study, …
Naima Nur, Azaz Bin Sharif, Anish Khan, Md Rashedul Islam, Hafid Soualhine, et al.
To effectively manage tuberculosis (TB), it is essential to address the high incidence of the disease, as multidrug-resistant pulmonary TB (MDR-PTB) remains a significant concern to halt pre-extensive drug-resistant (pre-XDR) recrudescence. The objective of the current study was …
Pinhata JMW, Brandao AP, Gallo JF, Oliveira RS, Ferrazoli L
… tests 385 phenotypically multidrug-resistant-Mycobacterium tuberculosis isolates from Sao Paulo, Brazil. Discordances were resolved by Sanger sequencing. MTBDRsl correctly detected 99.7% of the multidrug-resistant isolates, 87.8% of the pre-XDR, and 73.9% of the XDR. The assay s…
Gupta M, Ish P, Malhotra N
…guidelines on the Programmatic Management of Drug-Resistant Tuberculosis (DR-TB) in India (PMDT) have been released in March 2021 on World TB Day. The new guidelines have considered emerging diagnostic trends including TrueNat, Xpert Mtb/XDR, Next generation sequencing and evalua…
Saeed DK, Shakoor S, Razzak SA, Hasan Z, Sabzwari SF, et al.
…tations in the Rv0678, pepQ and atpE genes of Mycobacterium tuberculosis (MTB) have been reported to be associated with reduced antimycobacterial susceptibility to bedaquiline (BDQ). Resistance conferring mutations in treatment naïve MTB strains is likely to have implications for…
Olabisi Flora Davies-Bolorunduro, Bharkbhoom Jaemsai, Wuthiwat Ruangchai, Thanakron Noppanamas, Manon Boonbangyang, et al.
There are four major lineages of Mycobacterium tuberculosis (Mtb) whose geographic ranges vary considerably. Mtb lineage 2 (L2) or the East Asia lineage is particularly common in East and Southeast Asia, and also reported worldwide. Most L2 isolates belong to a sublineage L2.2 wh…
Lindiwe Modest Faye, Mojisola Clara Hosu, Ntandazo Dlatu, Vatiswa Henge-Daweti, Teke Apalata
…cularly in patients undergoing treatment for drug-resistant tuberculosis (DR-TB). In South Africa, where both TB and HIV are prevalent, the risk of treatment-related auditory damage is especially high. This study aimed to assess the prevalence and predictors of hearing impairment…
Faye LM, Hosu MC, Apalata T
…stigated the characteristics and outcomes of drug-resistant tuberculosis patients in selected rural healthcare facilities in the Eastern Cape, South Africa. A retrospective review of clinical records from 456 patients, covering the period from January 2018 to December 2020, revea…
Wrohan I, Nguyen TA, Nguyen VN, Nguyen BH, Hoang TTT, et al.
…ground Improving treatment outcomes for multidrug-resistant tuberculosis (MDR-TB) is a leading priority for global TB control. This retrospective cohort study evaluated the factors associated with treatment success among patients treated for MDR-TB in two provinces in Vietnam. Me…
Nurlan Takenov, Alibi Kaziyev, Asfendiyar Mukhamadi, Lyailya Chingissova, Bekzat Toxanbayeva, et al.
Tuberculosis, particularly multidrug-resistant TB (MDR-TB), remains a major public health concern in Kazakhstan, where 26% of new TB cases are MDR, far exceeding the global average. To better understand the genetic diversity, drug resistance, and transmission dynamics ofin Kazakh…
Divya Bhatt, Rashmi Ratnam, Faisal Abbas, Manu Singh, Urmila Singh, et al.
… address such challenges. Robust data analysis of geriatric tuberculosis (TB) is thus essential for preparedness to improve outcomes in this expanding vulnerable population. This study aims to identify the epidemiological, clinical, and comorbidity profiles of TB across various a…
Campos DL, Canales CSC, Demarqui FM, Fernandes GFS, Dos Santos CG, et al.
Tuberculosis remains a serious global health threat, exacerbated by the rise of resistant strains. This study investigates the potential of two benzofuroxan ( Bfx ) derivatives, 5n and 5b, as targeted treatments for MDR-TB using in silico , in vitro , and in vivo methodologies. I…
Gopalaswamy R, Palani N, Viswanathan D, Preysingh B, Rajendran S, et al.
Background : Patients with first-line drug resistance (DR) to rifampicin (RIF) or isoniazid (INH) as a first-line (FL) line probe assay (LPA) were subjected to genotypic DST using second-line (SL) LPA to identify SL-DR (including pre-XDR) under the National TB Elimination Program…
Rens C, Ceyssens PJ, Laval F, Lefèvre P, Mathys V, et al.
Treatment of tuberculosis still represent a major public health issue. The emergence of multi-and extensively-drug resistant (MDR and XDR) Mycobacterium tuberculosis clinical strains further pinpoint the urgent need for new anti-tuberculous drugs. We previously showed that vancom…
Mi Kim Y, Park Y, Soon Son E, Lee A, Bang S, et al.
…ivatives as part of our efforts to discover innovative anti-tuberculosis agents. Derivatives of spirocyclic POM were synthesized and evaluated for their inhibitory effects on M.tuberculosis (M. tb) H37Rv. Notably, compound 5c displayed potent anti-tubercular activity with MIC val…