Showing 26–50 of 200 documents
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Massi MN, Hidayah N, Handayani I, Iskandar IW, Djannah F, et al.
…ificance as an immunomarker for several diseases, including tuberculosis. This study aimed to determine the difference between miR-425-5p and miR-4523 expressions in patients with active pulmonary TB (PTB), latent TB infection (LTBI), and lymph node TB (LNTB), whose diagnosis rem…
Nababan B, Triasih R, Chan G, Dwihardiani B, Hidayat A, et al.
In Indonesia, the implementation of tuberculosis (TB) contact investigation is limited, with low detection rates. We report the yield of and risk factors for TB disease and infection for household contacts (HHCs) investigated using chest X-ray (CXR) screening. We identified HHCs …
Berrocal-Almanza LC, Harris R, Lalor MK, Muzyamba MC, Were J, et al.
… Evaluating interventions that might lead to a reduction in tuberculosis in high-income countries with a low incidence of the disease is key to accelerate progress towards its elimination. In such countries, migrants are known to contribute a large proportion of tuberculosis case…
Kim JW, Bowman K, Nazareth J, Lee J, Woltmann G, et al.
Background Incipient tuberculosis, a progressive state of Mycobacterium tuberculosis infection with an increased risk of developing into tuberculosis disease, remains poorly characterised. Animal models suggest an association of progressive infection with bacteraemia. Circulating…
Soraya Permata Sujana, Fadilah Habibul Hamda, Mufti As Siddiq, Yuniko Ibnu Latif, Al Asyary
**BACKGROUND:** Tuberculosis is one of the leading causes of death from infectious diseases in the world, with approximately 25% of the global population having latent tuberculosis infection. Secondhand smoke exposure has been recognised as a significant risk factor in the develo…
Belay M, Tulu B, Younis S, Jolliffe DA, Tayachew D, et al.
…rface marker have been posited as a niche for Mycobacterium tuberculosis complex bacilli during latent tuberculosis infection. Our aim was to determine whether M tuberculosis complex DNA is detectable in CD34-positive peripheral blood mononuclear cells (PBMCs) isolated from asymp…
Yang C, Yasseen AS 3rd, Stimec J, Rea E, Waters V, et al.
…ground There are few data about the utility of the Canadian tuberculosis medical surveillance system for detecting tuberculosis in children and adolescents. We sought to assess the prevalence of tuberculosis infection and disease in children and adolescents referred by the tuberc…
Saha A, Escuduero J, Layouni T, Richardson B, Hou S, et al.
…ound Pregnancy is a risk factor for progression from latent tuberculosis infection to symptomatic tuberculosis. However, how pregnancy influences T-cell responses to Mycobacterium tuberculosis is unknown. Methods We measured M. tuberculosis-specific cytokines, T-cell memory marke…
Barham MS, Whatney WE, Khayumbi J, Ongalo J, Sasser LE, et al.
…ficant risk factor for reactivation of latent Mycobacterium tuberculosis infection (LTBI) and progression to active tuberculosis disease, yet the mechanisms whereby HIV impairs T cell immunity to M. tuberculosis have not been fully defined. Evaluation of M. tuberculosis -specific…
Harirzadeh S, Kazemi MJ, Babakhani S
Introduction: Mycobacterium tuberculosis is the cause of pulmonary and extra-pulmonary tuberculosis. Latent tuberculosis is asymptomatic and the results of mycobacterial culture in this case are negative. The purpose of this study was to determine the prevalence of M. tuberculosi…
Warria K, Nyamthimba P, Chweya A, Agaya J, Achola M, et al.
Objective To compare the prevalence of tuberculosis infection and disease in household contacts of patients with bacteriologically confirmed tuberculosis disease and contacts of non-bacteriologically confirmed disease in western Kenya. Methods We enrolled newly diagnosed index pa…
Chen H, Zhou J, Zhao X, Liu Q, Shao L, et al.
… role of soluble immune checkpoints (sICs) in Mycobacterium tuberculosis (M. tb) infection remains unknown. We assessed the levels of multiple sICs in individuals with distinct M. tb infection status, and their dynamic changes during anti-tuberculosis treatment. Methods We enroll…
Winter JR, Smith CJ, Davidson JA, Lalor MK, Delpech V, et al.
… known to increase the likelihood of reactivation of latent tuberculosis to active TB disease; however, its impact on tuberculosis infectiousness and consequent transmission is unclear, particularly in low-incidence settings. Methods National surveillance data from England, Wales…
Ishikawa CS, Matsuo OM, Sarno F
… To describe the characteristics of patients diagnosed with tuberculosis and latent tuberculosis infection. Methods A retrospective study, between 2012 and 2015, with data from patients of Programa Einstein na Comunidade de Paraisópolis. To evaluate possible factors associated wi…
Jansen-Aaldring N, van de Berg S, van de Berg S, van den Hof S
…nd practices of patient support during treatment for active tuberculosis and for latent tuberculosis infection in European countries with a low incidence of tuberculosis and to identify potential best practices. Background Policies, practices and its' evaluations from similar set…
Adankwah E, Nausch N, Minadzi D, Abass MK, Franken KLMC, et al.
…ase assays (IGRAs) used for diagnosis of Mycobacterium (M.) tuberculosis infection have limited sensitivity. Alternative cytokines and M. tuberculosis latency-associated antigens may improve immune-based tests. Methods Multiplex cytokine analyses was done in culture supernatants …
Chu AL, Lecca LW, Calderón RI, Contreras CC, Yataco RM, et al.
…hown that cigarette smoking increases the infectiousness of tuberculosis patients, the impact of smoking cessation on tuberculosis transmissibility has not been evaluated. Methods Between 2009 and 2012, we enrolled 4500 tuberculosis patients and followed 14 044 household contacts…
Rakotomanana F, Dreyfus A, Randrianarisoa MM, Raberahona M, Chevallier E, et al.
The incidence rate of tuberculosis in prisons is estimated to be 8 times greater than that in the general population in Madagascar. Our objectives were to estimate the prevalence of pulmonary tuberculosis and HIV infection among prisoners and to identify risk factors associated w…
Mehaffy C, Kruh-Garcia NA, Graham B, Jarlsberg LG, Willyerd CE, et al.
Identification of biomarkers for latent Mycobacterium tuberculosis infection and risk of progression to tuberculosis (TB) disease are needed to better identify individuals to target for preventive therapy, predict disease risk, and potentially predict preventive therapy efficacy.…
Ndzi EN, Nkenfou CN, Pefura EWY, Mekue LCM, Guiedem E, et al.
Diagnosis of tuberculosis still faces a lot of challenges and is one of the priorities in the field of tuberculosis management. Deciphering the complex tuberculosis pathogenicity network could provide biomarkers for diagnosis. We discussed the distribution of HLA-B17, -DQB and -D…
Meier NR, Jacobsen M, Ottenhoff THM, Ritz N
Background: Current immunodiagnostic tests for tuberculosis (TB) are based on the detection of an immune response toward mycobacterial antigens injected into the skin or following an in-vitro simulation in interferon gamma-release assays. Both tests have limited sensitivity and a…
Jarvela J, Moyer M, Leahy P, Bonfield T, Fletcher D, et al.
Tuberculosis (TB) remains a worldwide public health threat. Development of a more effective vaccination strategy to prevent pulmonary TB, the most common and contagious form of the disease, is a research priority for international TB control. A key to reaching this goal is improv…
Makatsa MS, Omondi FMA, Bunjun R, Wilkinson RJ, Riou C, et al.
The development of a highly effective tuberculosis (TB) vaccine is likely dependent on our understanding of what constitutes a protective immune response to TB. Accumulating evidence suggests that CD4 + T cells producing IL-22, a distinct subset termed "Th22" cells, may contribut…
Essone PN, Leboueny M, Maloupazoa Siawaya AC, Alame-Emane AK, Aboumegone Biyogo OC, et al.
Tuberculosis (TB) is the leading cause of death due to an infectious agent, but only a small fraction of those infected develop the disease. Cytokines are involved in the mediation and regulation of immunity, and their secretion patterns may reflect the infection status. To incre…
Kang J, Jeong DH, Han M, Yang SK, Byeon JS, et al.
Background We investigated the incidence of active tuberculosis among patients with inflammatory bowel disease (IBD) treated with tumor necrosis factor (TNF) inhibitors, with or without latent tuberculosis infection (LTBI). Methods The study was performed at a Korean tertiary ref…