Showing 26–50 of 200 documents
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Davuluri KS, Singh AK, Kumar V, Singh SV, Singh AV, et al.
…that VEGF growth factor induces neovascularization in human tuberculosis (TB) patients, but the evidence is inconclusive. Considerable ambiguity exists concerning the factors responsible for miliary tuberculosis. To identify such factors, we proposed an alternative explanation th…
Meregildo Rodriguez ED
Central nervous system (CNS) tuberculosis includes three clinical entities: tuberculous meningitis, intracranial tuberculoma, and spinal tuberculous arachnoiditis. All three categories are encountered frequently in regions of the world where the incidence of TB is high. Meningeal…
Li S, Wu R, Feng M, Zhang H, Liu D, et al.
Spinal tuberculosis is a common extrapulmonary type that is often secondary to pulmonary or systemic infections. Mycobacterium tuberculosis infection often leads to the balance of immune control and bacterial persistence. In this study, 64 patients were enrolled and the clinicopa…
Admassu W, Ayelign B, Abebe G, Tadesse M
Background Rapid diagnosis of tuberculosis (TB) and detection of drug resistance are very important for timely and appropriate management of patients. Xpert MTB/RIF assay is approved for use in TB and rifampicin-resistance diagnosis. However, data are limited on the impact of Xpe…
Achache W, Boualam MA, Cassir N, Mimari C, Poitrenaud D, et al.
Laryngeal tuberculosis is a rare form of extrapulmonary tuberculosis that questions the natural history of this infection. We report one such case in which a pathological examination of a laryngeal biopsy revealed granulomatous inflammation with caseous necrosis. Further investig…
The Updated guidelines on Management of tuberculosis in children and adolescents include new recommendations that cover diagnostic approaches for TB, shorter treatment for children with non-severe drug-susceptible TB, a new option for the treatment of TB meningitis, the use of be…
Das R, Chandrasekar S, Purohit G, Satapathy AK, John J, et al.
Ocular tuberculosis (OTB) is a rare form of extrapulmonary Tuberculosis (EPTB) and a rare presenting feature of tuberculosis (TB) in children. We report such a case in a 3-year-old boy who presented with a painless swelling over left upper eyelid. Mycobacterium tuberculosis bacil…
Kang W, Yu J, Liang C, Wang Q, Li L, et al.
Background Tuberculosis (TB), a multisystemic disease with protean presentation, remains a major global health problem. Although concurrent pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) cases are commonly observed clinically, knowledge regarding concurrent P…
Hammami F, Ben Ayed H, Koubaa M, Chakroun A, Hsairi M, et al.
Background/objectives Tuberculosis is a multisystem disease that might affect any organ. Abdominal tuberculosis (ABT) represents 5-17% from all extrapulmonary tuberculosis (EPT) sites. We aimed to study the clinical, laboratory and evolutionary features of ABT cases and to identi…
Gwalabe SA, Dunga JA, Misau YA, Maigari IM, Adamu A
Background Extra- pulmonary tuberculosis ( EPTB) contributes to the burden of Tuberculosis (TB) especially in developing countries. Despite this fact, information on the prevalence of EPTB is scarce. The aim of this study is to determine the five-year prevalence of EPTB among pat…
Fiske CT, Blackman A, Maruri F, Rebeiro PF, Huaman M, et al.
…ersons with previous EPTB, previous pulmonary TB, latent M. tuberculosis infection, and uninfected TB contacts. Persons with previous pleural TB were excluded due to enhanced immune responses at the site of disease. Methods Macrophages were stimulated with TLR-2 agonist M. tuberc…
Yadav S
Tuberculosis is a disease with presentations both in the lungs and at other extrapulmonary sites. While pulmonary tuberculosis constitutes a significant proportion of total tuberculosis cases, extrapulmonary cases with infections at rare sites are also documented. Herein, an exce…
Diriba G, Alemu A, Tola HH, Eshetu K, Yenew B, et al.
…ed to determine the frequencies and trends of Mycobacterium tuberculosis and rifampicin resistance among presumptive tuberculosis patients in Ethiopia, who were tested using the Xpert MTB/RIF assay between 2014 and 2021. Methods Data were collected retrospectively from patient re…
Chin KL, Suing EJ, Andong R, Foo CH, Chan SK, et al.
Spinal tuberculosis, also referred to as Pott's disease, presents a significant risk of severe paralysis if not promptly detected and treated, owing to complications such as spinal cord compression and deformity. This article presents the genetic analysis of a Mycobacterium tuber…
Dolmus T, Ensarioglu K, Sahin Ozdemirel T, Kurus M, Ozkara S
Tuberculosis is an infectious disease that may involve all systems, with the respiratory system being the most commonly affected. Tuberculosis of the chest wall and its structures is rare, in which malignancy and abscess may be counted among possible differential diagnoses. In th…
Yin J, Yan G, Qin L, Zhu C, Fan J, et al.
Background Extrapulmonary tuberculosis (EPTB) without symptomatic pulmonary involvement has been thought to be non-transmissible, but EPTB with asymptomatic pulmonary tuberculosis (PTB) could transmit tuberculosis (TB). Genomic investigation of Mycobacterium tuberculosis (Mtb) is…
Sunnetcioglu M, Baran AI, Binici I, Esmer F, Gultepe B
…nges in demographic and clinical features of extrapulmonary tuberculosis cases. Methods This retrospective study was conducted at Yuzuncu Yil University, Van, Turkey, and comprised records of extrapulmonary tuberculosis patients treated between January 2009 and July 2014 at the t…
Niu Q, Wu R, Pan K, Ge X, Chen W, et al.
Hepatic tuberculosis (HTB) is rare extrapulmonary tuberculosis that is clinically similar to liver malignancy, making it difficult for correct diagnoses. Pathology is the gold standard for tuberculosis diagnosis. However, there are few reports on the pathological features of HTB.…
Ruesen C, Chaidir L, van Laarhoven A, Dian S, Ganiem AR, et al.
Background Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant. Methods We whole-ge…
Dileep Tiwari, Shafiul Haque, Ram P Tiwari, Arshad Jawed, Thavendran Govender, et al.
…ostic test was developed for the detection of Mycobacterium tuberculosis antigens in serum samples of active tuberculosis (TB) and extrapulmonary TB patients via a liposomal agglutination-based method. **METHODS:** A rapid card test has been developed to facilitate the recogniti…
Elin Folkesson, Gabrielle Fröberg, Christopher Sundling, Thomas Schön, Erik Södersten, et al.
… World Health Organization (WHO) test targets for pulmonary tuberculosis (PTB) with high bacillary loads. We investigated the contribution of MTB-HR as a nonsputum, near point-of-care diagnostic method in other prioritized groups, such as extrapulmonary tuberculosis (EPTB) and pa…
Diriba G, Alemu A, Eshetu K, Yenew B, Gamtesa DF, et al.
…actual burden of bacteriologically confirmed extrapulmonary tuberculosis (EPTB) and risk factors in Ethiopia is not well known due to the lack of a strong surveillance system in Ethiopia. Thus, this study was conducted to estimate the pooled prevalence of bacteriologically confir…
He Y, Lyon CJ, Nguyen DT, Liu C, Sha W, et al.
Diagnosis of pediatric tuberculosis (TB) is often complicated by its nonspecific symptoms, paucibacillary nature, and the need for invasive specimen collection techniques. However, a recently reported assay that detects Mycobacterium tuberculosis virulence factors in serum can di…
Addo SO, Abrahams AOD, Mensah GI, Mawuli BA, Mosi L, et al.
…ity of immunohistochemistry (IHC) using anti- Mycobacterium tuberculosis antibody (ab905) for detecting the presence of mycobacterial antigens in archived formalin-fixed paraffin-embedded (FFPE) tissues. Methods FFPE tissues [surgical biopsies (n = 32) and post-mortem tissues (n …
Xichao Ou, Peilei Hu, Xundi Bao, Zhou Liu, Chong Teng, et al.
…ication and testing (AutoSAT) method in suspected pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) by comparing with Xpert MTB/RIF (Xpert) method against the composite reference standard. **METHOD:** Patients with suspected PTB or EPTB were enrolled consecutiv…