Showing 26–50 of 200 documents
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Kusmiati T, Burhan E, Sugiyono RI, Arlinda D, Naysilla AM, et al.
…nary histoplasmosis can occur simultaneously with pulmonary tuberculosis (TB) or as an alternative diagnosis in clinically-diagnosed TB patients with no microbiological evidence of TB. This study aimed to determine the seroprevalence of anti-H. capsulatum IgG antibody among pulmo…
Muhammed S Bah, Kyaw Ko Ko Htet, Gregory P Bisson, Celso Khosa, Refiloe Masekela, et al.
Tuberculosis (TB) remains a major public health issue across the world and national TB guidelines are an important resource for diagnosis and treatment. This scoping review aimed to analyze how countries with the highest TB burdens approach the integration of comorbidity and risk…
Burusie A, Enquesilassie F, Salazar-Austin N, Addissie A
…g the implementation of the World Health Organization's End Tuberculosis (TB) Strategy is the treatment outcome rate. Objective This study aims to assess the magnitude of unfavorable treatment outcomes and estimate their relationship with baseline undernutrition and sustained und…
Kivrane A, Ulanova V, Grinberga S, Sevostjanovs E, Viksna A, et al.
…). However, the effect of genetic polymorphisms on the anti-tuberculosis (anti-TB) drug, and particularly rifampicin (RIF), exposure or anti-TB drug-induced liver injury (DILI) remains uncertain. Here, we evaluated the relationship between single nucleotide polymorphisms (SNPs) d…
Timire C, Houben RMGJ, Pedrazzoli D, Ferrand RA, Calderwood CJ, et al.
Tuberculosis (TB) disproportionally affects poor people, leading to income and non-income losses. Measures of socioeconomic impact of TB, e.g. impoverishment and patient costs are inadequate to capture non-income losses. We applied impoverishment and a multidimensional measure on…
Sarita Mukura, Parinya Ruenwilai
**OBJECTIVES:** First-line anti-tuberculosis (TB) medications are effective for drug-susceptible TB but are commonly associated with hepatotoxicity, which can compromise treatment adherence and contribute to drug resistance. This study aimed to determine the frequency of anti-TB …
de Groot LM, Straetemans M, Maraba N, Jennings L, Gler MT, et al.
Worldwide, non-adherence to tuberculosis (TB) treatment is problematic. Digital adherence technologies (DATs) offer a person-centered approach to support and monitor treatment. We explored adherence over time while using DATs. We conducted a meta-analysis on anonymized longitudin…
Merza MA
…and clinical profile and treatment outcomes in the National Tuberculosis Program Center of Duhok governorate. Methods This was a descriptive retrospective study of all forms of drug-susceptible tuberculosis cases in the National Tuberculosis Program Center of Duhok. The Electroni…
Said B, Charlie L, Getachew E, Wanjiru CL, Abebe M, et al.
The lack of rapid, sensitive, and deployable tuberculosis diagnostic tools is hampering the early diagnosis of tuberculosis and early detection of treatment failures. The conventional sputum smear microscopy or Xpert MTB/RIF assay cannot distinguish between alive and dead bacilli…
Malik AA, Farooq S, Jaswal M, Khan H, Nasir K, et al.
Background Shorter regimens for tuberculosis prevention can improve completion rates and protection against developing active tuberculosis disease after tuberculosis exposure. We aimed to assess the safety and feasibility of 1 month of daily isoniazid and rifapentine (1HP) in chi…
Seid G, Alemu A, Diriba G, Zerihun B, Abebaw Y, et al.
Introduction There is a global gap between tuberculosis incident cases and the notified cases. Active household contact investigation is one of the strategies to narrow this gap. It has the advantage of giving early diagnosis and preventive treatment to vulnerable and eligible gr…
du Preez K, Osman M, Seddon JA, Naidoo P, Schaaf HS, et al.
Background Few studies have evaluated tuberculosis control in children and adolescents. We used routine tuberculosis surveillance data to quantify age- and human immunodeficiency virus (HIV)-stratified trends over time and investigate the relationship between tuberculosis, HIV, a…
Churako H, Tesema M, Tema L, Ababiya T, Wodajo D, et al.
…als worldwide are afflicted by the fatal infectious disease tuberculosis, which accounts for thousands of avoidable deaths. The literature has provided a good description of the clinical manifestation and radiologic features of pulmonary tuberculosis. However, the parenchymal com…
Nie L, Tong J, Wu G, Du J, Shang Y, et al.
…afloxacin has a potent killing effect against Mycobacterium tuberculosis , including drug-resistant strains, which is superior to that of other available quinolones. However, its efficacy in patients with primary-sensitive tuberculosis is unclear. This study aims to evaluate the …
Iskandar D, Suwantika AA, Pradipta IS, Postma MJ, van Boven JFM
Background The global incidence of tuberculosis is decreasing, yet it remains high in Indonesia. The Indonesian National Tuberculosis Program facilitates mandatory notification, which enables early detection and treatment, minimises complications, prevents transmission, and decre…
Cross GB, Sari IP, Kityo C, Lu Q, Pokharkar Y, et al.
…ckground Shorter treatments are needed for drug-susceptible tuberculosis. Adjunctive statins increase bactericidal activity in preclinical tuberculosis models. We investigated the safety and efficacy of adjunctive rosuvastatin in people with tuberculosis. We tested the hypothesis…
Liu Q, You N, Pan H, Shen Y, Lu P, et al.
Rationale: Patients with newly diagnosed tuberculosis often have inconsistent glycemic measurements during and after treatment. Distinct glycemic trajectories after the diagnosis of tuberculosis are not well characterized, and whether patients with stress hyperglycemia have poor …
Wei X, Hicks JP, Zhang Z, Haldane V, Pasang P, et al.
…ed as a complement to directly observed treatment (DOT) for tuberculosis, as DOT is inconvenient and costly. However, existing evidence about the effectiveness of these monitors is inconclusive. Therefore, we evaluated the effectiveness of a comprehensive package based on electro…
Chatterjee S, Das P, Shikhule A, Munje R, Vassall A
Historically, economic studies on tuberculosis estimated out-of-pocket expenses related to tuberculosis treatment and catastrophic cost, however, no study has yet been conducted to understand the post-treatment economic conditions of the tuberculosis patients in India. In this pa…
Amira Mahmood, Mohammad Bilal Ashfaq, Catherine Drain, Eoin Melby, Michael Hunter, et al.
Tuberculosis remains the biggest global killer from infectious causes, with an estimated 1.25 million deaths per year. The quadruple drug regimen of rifampicin, isoniazid, pyrazinamide, and ethambutol has been standard therapy for 40 years, with good outcomes in patients with dru…
Suresh S, Begum RF, Singh SA, Vellapandian C
…ng and clever strategy that is being developed to eradicate tuberculosis amid challenges, of which one of the major challenges is the resistance developed towards antibiotics used in standard directly observed treatment, short-course regimen. Surpassing the challenges in developi…
Safi H, Gopal P, Lingaraju S, Ma S, Levine C, et al.
The length and complexity of tuberculosis (TB) therapy, as well as the propensity of Mycobacterium tuberculosis to develop drug resistance, are major barriers to global TB control efforts. M. tuberculosis is known to have the ability to enter into a drug-tolerant state, which may…
Bonnet M, Vasiliu A, Tchounga BK, Cuer B, Fielding K, et al.
Background Globally, the uptake of tuberculosis-preventive treatment (TPT) among children with household tuberculosis contact remains low, partly due to the necessity of bringing children to health facilities for investigations. This study aimed to evaluate the effect on TPT init…
Lee GO, Comina G, Hernandez-Cordova G, Naik N, Gayoso O, et al.
Cough is a characteristic symptom of tuberculosis, is the main cause of transmission, and is used to assess treatment response. We aimed to identify the best measure of cough severity and characterize changes during initial tuberculosis therapy. We conducted a prospective cohort …
Li X, Qi X, Wang B, Fu L, Chen X, et al.
…ed the need for alternative therapies against Mycobacterium tuberculosis, the causative agent of TB. Methods MICs and intracellular macrophage cfu counts were tested to evaluate the antibacterial activity of nintedanib and pirfenidone against drug-susceptible and -resistant M. tu…