Showing 26–50 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Ram Bahadur Khadka, Samrat Parajuli, Nabin Pahari
…int indicates the importance of integrating microbiological diagnostics into orthopedic practice in resource limited settings. It highlights key laboratory tools, outlines the barriers to their effective use, and proposes locally adaptable strategies to improve diagnostic accurac…
Jin Yin, Min Yu
**BACKGROUND:** For bacteriologically negative suspected tuberculosis, immunological testing provides important diagnostic evidence. The traditional tuberculin skin test has poor specificity. QuantiFERON-TB Gold Plus (QFT-Plus, the latest generation of Interferon-Gamma Release As…
Li L, Wang Y, Zhang R, Liu D, Li Y, et al.
Patients with tuberculous pleurisy often remain undiagnosed even after blind thoracentesis and closed pleural biopsy (PB). In this study, we assessed the value of computed tomography (CT)-guided core needle biopsy of pleural lesion and evaluated the diagnostic accuracy of polymer…
Johansen ØH, Abdissa A, Zangenberg M, Mekonnen Z, Eshetu B, et al.
Background Cryptosporidiosis is a common cause of diarrhoea in young children (aged younger than 24 months) in low-resource settings but is currently challenging to diagnose. Light-emitting diode fluorescence microscopy with auramine-phenol staining (LED-AP), recommended for tube…
Wood RC, Luabeya AK, Dragovich RB, Olson AM, Lochner KA, et al.
Tongue dorsum swabbing is a potential alternative to sputum collection for tuberculosis (TB) testing. Previous studies showed that Cepheid Xpert MTB/RIF Ultra (Xpert Ultra) can detect Mycobacterium tuberculosis DNA on tongue swabs stored in buffer, with 72% sensitivity and 100% s…
Sood M, Sharma S, Sood S, Sharma V
Tuberculosis is predicted to be a major undocumented cause of mortality in children. This systematic review with meta-analysis assessed the diagnostic accuracy of Lipoarabinomannan antigen testing (FujiLAM) in urine in HIV-negative children with TB-like signs and symptoms. PubMed…
Mahato RP, Kumar S
Tuberculosis (TB) is still the most frequent cause of morbidity and mortality in the world caused by Mycobacterium tuberculosis (MTB). Due to slow diagnostic and treatment options, the disease is a major concern for public health and also increases the burden on the global econom…
Zhao X, Cui K, Bai L, Xu S, Liu W, et al.
This study aimed to evaluate the diagnostic value of rapid simultaneous RNA amplification and testing for tuberculosis (SAT-TB) in smear-negative pulmonary tuberculosis (PTB). We performed a multicenter prospective analysis of 206 patients with smear-negative suspected PTB betwee…
Mamishi S, Pourakbari B, Sadeghi RH, Marjani M, Mahmoudi S
Introduction Several studies have been conducted to find new biomarkers for the discrimination of Latent Tuberculosis Infection (LTBI) from active TB (ATB); however, their findings are inconsistent. The aim of the current study was to evaluate the potential of in vitro antigenspe…
Lu Zhang, Frederick L Altice, Adeeba Kamarulzaman, Ahsan Ahmad, Sangeeth Kaur, et al.
**BACKGROUND:** The World Health Organization (WHO) recommends tuberculosis (TB) screening in prisons but data on specific strategies are lacking. **METHODS:** Men sequentially entering Kajang Prison, Malaysia's largest prison, underwent standardized WHO symptom screening (SS), …
Moreira FMF, Verma R, Pereira Dos Santos PC, Leite A, da Silva Santos A, et al.
Background There is a need to identify scalable tuberculosis screening strategies among high burden populations. The WHO has identified a non-sputum-based triage test as a development priority. Methods We performed a diagnostic case-control study of point-of-care C-reactive prote…
Zhou Y, Lin P, Xia L, Heidari AA, Chen Y, et al.
Talaromycosis (TSM) affects immunocompromised individuals, particularly those with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), causing varied pulmonary abnormalities on chest computed tomography (CT). These features overlap with pulmonary tubercu…
Elsohaby I, Alahadeb JI, Mahmmod YS, Mweu MM, Ahmed HA, et al.
The aim of the present study was to calculate the sensitivity (Se) and specificity (Sp) of the single cervical tuberculin test (SCT), rapid lateral flow test (RLFT), and real-time polymerase chain reaction (RT-PCR) for the diagnosis of Mycobacterium bovis ( M. bovis ) infection i…
Juliana G E Bartels, Nurlan Takenov, Lyailya Chingissova, Anar Rakisheva, Ainur Eleusizova, et al.
**BACKGROUND:** Rapid, accurate detection ofand drug resistance is crucial to reduce tuberculosis (TB) burden and prevent development of drug resistance in high-burden drug-resistant TB regions. **METHODS:** From December 2021 to July 2022, sputum samples from 1214 adult patient…
Fatma Z Kamel, Nagwan Adel Ismail, Asmaa Z Khater, Alia A El Shahawy, Noura Almadani, et al.
Tuberculosis and sarcoidosis can present with similar clinical and radiological features, especially intrathoracic lymphadenopathy, complicating differential diagnosis. This study explored the potential utility of QuantiFERON-TB Gold (QFT), serum High Mobility Group Box 1 protein…
Nathavitharana RR, Lederer P, Chaplin M, Bjerrum S, Steingart KR, et al.
Background Tuberculosis is the primary cause of hospital admission in people living with HIV, and the likelihood of death in the hospital is unacceptably high. The Alere Determine TB LAM Ag test (AlereLAM) is a point-of-care test and the only lateral flow lipoarabinomannan assay …
Deo S, Singh S, Jha N, Arinaminpathy N, Dewan P
Background Tuberculosis (TB) incidence in India continues to be high due, in large part, to long delays experienced by patients before successful diagnosis and treatment initiation, especially in the private sector. This diagnostic delay is driven by patients' inclination to swit…
Keter AK, Lynen L, Van Heerden A, Goetghebeur E, Jacobs BKM
Background In application studies of latent class analysis (LCA) evaluating imperfect diagnostic tests, residual dependence among the diagnostic tests still remain even after conditioning on the true disease status due to measured variables known to affect prevalence and/or alter…
Umubyeyi Nyaruhirira A, Scholten JN, Gidado M, Suarez PG
…(COVID-19) undermines control of other infectious diseases. Diagnostics are critical in health care. This opinion paper explores approaches for leveraging diagnostics for COVID-19 while retaining diagnostics for other infectious diseases, including tuberculosis (TB) and HIV. The …
Yue Gao, Ling Hai, Yan Niu, Hong-Zhe Zhu, Rui Niu, et al.
**BACKGROUND:** Interleukin-27 (IL-27) in the pleural fluid has gained significant attention as a diagnostic biomarker for tuberculous pleural effusion (TPE); however, considerable variability exists across available studies. This systematic review and meta-analysis aimed to dete…
Hongling Wang, Liyan Jiang, Yang Xiao, Linlin Xu, Ning Zhang, et al.
**OBJECTIVES:** Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disorder causing multi-organ damage. Current diagnostic methods are hindered by inadequate sensitivity and specificity of conventional biomarkers, which frequently delay diagnosis. Therefore, iden…
Miller AC, Cavanaugh JE, Arakkal AT, Koeneman SH, Polgreen PM
Background The incidence of diagnostic delays is unknown for many diseases and specific healthcare settings. Many existing methods to identify diagnostic delays are resource intensive or difficult to apply to different diseases or settings. Administrative and other real-world dat…
Anvita Gupta Malhotra, Leena Lokhande, Abhijit Pakhare, Payal Soni, Satya Prakash Vishwakarma, et al.
… These findings advocate for integrating advanced molecular diagnostics into routine tuberculosis workflows to reduce diagnostic delays and improve patient outcomes. **CLINICAL TRAIL NUMBER:** Not applicable.
Broger T, Marx FM, Theron G, Marais BJ, Nicol MP, et al.
…le. Despite the roll-out of molecular WHO-recommended rapid diagnostics to replace sputum smear microscopy over the past decade, a large diagnostic gap remains. Of the estimated 10·6 million people who developed tuberculosis globally in 2022, more than 3·1 million were not diagno…
Wen Rao, Dafu Wang, Xiaoxue Ma, Jian Zhou, Tingting Gong, et al.
**BACKGROUND:** Rifampicin-resistant tuberculosis (RR-TB) constitutes a persistent and formidable challenge for global TB control programs, as delayed diagnosis and treatment initiation contribute to transmission and poor outcomes. Molecular drug susceptibility testing (mDST) ena…