Showing 1–25 of 200 documents
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Olanisun P Adewole, MD, Bolanle A Omotoso, MD
Tuberculosis (TB) is caused by mycobacterial organism. It is the leading infectious disease cause of death globally, with more than 10 million new cases and over 2 million deaths annually. Developing countries bear the greatest brunt of the disease. The long duration of current t…
E. E. Lesnik, S. Ginda
…ers of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological manifestations. Subjects and Methods. A prospective study was conducte…
Jannat Nabaziwa, Eustes Kigongo, Amir Kabunga, Walter Acup, Sean Steven Puleh
Uganda has a high incidence of tuberculosis infection at 200 cases per 100,000 people. With effective therapy and adherence to medications is essential for reducing the spread of tuberculosis in the community. However, many of the initiated patients do not get to finish the entir…
Vaidehi Mehta, Ramsha Ansari, Ira Shah
Mixed tuberculosis occurs with multiple clonally distinct mycobacterium tuberculosis strains in an individual. We present a 12-year-old girl with steroid-resistant nephrotic syndrome and drug-sensitive pulmonary tuberculosis (Xpert MTB/Rif) and preextensively drug-resistant tuber…
Shaki Aktar
The prevalence of tuberculosis (TB) is reducing in Bangladesh, but the emergence of drug resistant tuberculosis make the TB control effort more challenging and questionable. The present study aimed to identify the socio-demographic, behavioral and clinical risk factors for develo…
Debdeep Mitra, P. Sanyal, Divya Kamboj, Rakesh Kumar Deepak, Sayan Chakraborty, et al.
…way in suppression of T cell response against Mycobacterium tuberculosis (M.tb) among tuberculosis (TB) patients. Here, we checked the status of host immune response among the drug resistant (DR) and Drug Sensitive (DS) tuberculosis (TB) patients. Additionally, in a phase I/ II c…
Abhinav Pandey, Abhijeet, Rajendra Pal Singh, Palak Goyal, Huma Khan, et al.
…duction: Despite being a fully treatable infectious disease,tuberculosis remains among the major causes of death. Earlydiagnosis and antibiotic treatment are essential for stopping thespread of TB. Treatment is now more challenging and expensivedue to the emergence of drug-resist…
Putri Immi Rizky Budiyani, Ratna Djuwita, Renti Mahkota, Dwi Handayani
Tuberculosis and HIV are serious health issues that can significantly impact an individual's immune system by evading immune monitoring functions. Research on TB-HIV treatment success, especially in DKI Jakarta province, is still limited. This study aims to assess the treatment s…
World Health Organization
This web annex to the WHO consolidated guidance on tuberculosis data generation and use provides practical examples illustrating how tuberculosis (TB) diagnosis, treatment initiation and treatment outcomes should be recorded and reported within TB surveillance systems. Using a se…
Styliani Karanika, Tianyin Wang, Addis Yilma, Jennie Ruelas Castillo, James T. Gordy, et al.
Abstract Mycobacterium tuberculosis ( Mtb) is one of the leading infectious causes of death worldwide. There is no available licensed therapeutic vaccine that shortens active tuberculosis (TB) disease drug treatment and prevents relapse, despite the World Health Organization’s ca…
U. C. Samudyatha, Prasanna B T Kamath
Background: Gaps in Tuberculosis Preventive Treatment (TPT) cascade among household contacts (HHCs) of Tuberculosis patients are often attributed to the knowledge gaps among the HHCs. Objectives: To examine the factors affecting the uptake of IGRA testing among HHCs of drug-susce…
Deepak Saxena, Devang Raval, Somen Saha, Jignasa Sathwara, Nishad Halkarni, et al.
…sec> <title>BACKGROUND</title> Patients with Drug sensitive tuberculosis (DSTB) often face challenges in adhering to medications. Tuberculosis Monitoring Encouragement Adherence Drive (TMEAD) is a digital pillbox that provides reminders for pill consumption and facilitates the re…
Wilber Sabiiti, Emmanuel Musisi, Bariki Mtafya, Peter M. Mbelele, Khalide Azam, et al.
<h3>Background</h3> Tuberculosis (TB) treatment is long and complex. Here we summarise data from EDCTP-funded studies of the Tuberculosis Molecular Bacterial Load Assay (TB-MBLA) as a TB treatment monitoring tool. <h3>Methods</h3> Treatment naïve participants from four Sub-Sahara…
Nisha Wanichwecharungruang, Weerinth Puyati, Thanyanuch Sanchat
…nth rifampicin-based regimen for drug-susceptible pulmonary tuberculosis. Clinical trials reported serious adverse drug reactions (ADRs) in only 18% of patients, with a low incidence of grade 3 hyperbilirubinemia (3.3%) in the HPMZ group. However, real-world practice at our insti…
Somen Saha, Devang Raval, Deepak Saxena, Nishad Halkarni, Rahul Doshi, et al.
Abstract Background Drug-sensitive tuberculosis (DSTB) patients often face challenges in adhering to medications. Tuberculosis Monitoring Encouragement Adherence Drive (TMEAD)is an electronic cartridge-based dispensing module that dispenses patients’ daily dose in a small disposa…
O. Omosebi, Olanrewaju S.O., Adejumo O.A.
…nce, this paper aims to model the outcome of drug-resistant-tuberculosis and drug-susceptible-tuberculosis patients in Oyo state of Nigeria using the logit function of estimating binary logistic regression model vis-à-vis identifying the success of these TB treatments. At baselin…
Alfi Nurul Islamiyah, Syarifuddin Syarifuddin, Morsalina Akhsa, Iis Rukmawati, Eni Margayani, et al.
Tuberculosis (TB) remains a significant global health concern, particularly in Indonesia. Ensuring rational TB treatment is crucial for effective disease control and preventing the emergence of drug resistance. This study aimed to evaluate the rationality of TB treatment among ne…
Ruchita A Sakaria, Bina Modi, Anjana MS, Bharti Koria, Kamlesh Vithalani
Introduction: Drug-resistant tuberculosis (DR-TB) poses a significant public health challenge in India. While treatment success in DR-TB cases remains limited, bedaquiline-based oral longer regimens have shown promising results in select studies. Objective: This study aimed to ev…
Argita D. Salindri
The global strategy to end tuberculosis (TB) includes interim goals to reduce TB incidence by 80% and TB mortality by 90% by the end of 2030. However, global TB control primarily focuses on achieving favorable TB treatment outcomes (i.e., microbial cure or treatment completion). …
Collins Timire, Rein M G J Houben, Debora Pedrazzoli, Rashida A. Ferrand, Claire Calderwood, et al.
Introduction: Tuberculosis (TB) disproportionally affects poor people, leading to income and non-income losses. Measures of socioeconomic impact of TB, e.g. impoverishment and patient costs are inadequate to capture non-income losses. We applied impoverishment and a multidimensio…
Ahmad Fuady
Estimating tuberculosis incidence, prevalence, and deaths are crucial to capture the tuberculosis burden and to assess the progress towards tuberculosis elimination in 2035. WHO publishes a report of estimated tuberculosis burden each year, showing that tuberculosis remains among…
Helena Rabie, Marieke M. van der Zalm
Rapid microbiological confirmation of Mycobacterium tuberculosis (M tuberculosis) in sputum with nucleic acid amplification tests (TB-NAAT) is an important step to diagnose tuberculosis and to identify possible drug resistance. These tests significantly increase the diagnostic yi…
Lindsay McKenna, Jennifer Furin
Around 10 million people become sick with tuberculosis, and more than 1·2 million people die from the disease each year.1WHOGlobal Tuberculosis Report.https://www.who.int/tb/publications/global_report/en/Date: 2019Date accessed: October 31, 2019Google Scholar WHO has proposed som…
Conor J. Meehan
…or response Article and author information Metrics Abstract Tuberculosis disproportionately affects the Canadian Inuit. To address this, it is imperative we understand transmission dynamics in this population. We investigate whether ‘deep’ sequencing can provide additional resolu…
Robyn S. Lee, Jean‐François Proulx, Fiona McIntosh, Marcel A. Behr, William P. Hanage
…or response Article and author information Metrics Abstract Tuberculosis disproportionately affects the Canadian Inuit. To address this, it is imperative we understand transmission dynamics in this population. We investigate whether ‘deep’ sequencing can provide additional resolu…