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Helen Ayles, Professor
Tuberculosis (TB) has overtaken HIV as the leading infectious cause of death worldwide and requires a major policy shift for it to be controlled in line with the WHO Stop-TB goal to "end TB". However, how to control TB at population level in the context of HIV, is unknown. Some o…
Surendra K Sharma, M.D., Ph.D
HIV induced altered representation and function of regulatory T cell subsets (NKT and Treg cells) impair the protective T cell response against M.tuberculosis and disrupts LTBI, thus facilitates faster progression and development of severe forms of clinical TB in HIV-TB co-infect…
VINA LUSIANA
…an Immunode_ciency Virus/Acquired Immuno-deciency Syndrome (HIV/AIDS) are major burden of infectious diseases in developing countries. TB and HIV infection have the effect of deeply on assault the immune system, since they can afford to weaken host immune respone through a mechan…
Vannesa Yue May Teng, Yan Ting Chua, Eunice En Ni Lai, Shilpa Mukherjee, Jessica Michaels, et al.
…TRACT Objectives Tuberculosis (TB) is a common infection in HIV patients. Our study aims to determine the prevalence and characteristics of HIV-TB co-infected patients in Singapore, a high-income, intermediate TB-burden country. Methods Retrospective data of 11-years was obtained…
Linda Gail Bekker, MBChB, FCP, PhD, James McIntyre, MBChB, MRCOG
…e Town, South Africa, a community with high rates of TB and HIV. This study will also examine the genetics of TB and the relationships among active TB infection, new HIV infections, and HIV disease progression. TB is the most common opportunistic infection and the single most co…
Yuyun Monita, Putroue Keumala Intan
The condition in which an individual is affected by TB and HIV/AIDS in his body is called a TB-HIV/AIDS coinfection. This research aims to minimize the populations of TB-HIV/AIDS coinfection with a minimum expenditure on medical expenses, that means minimizing the objective’s fun…
Ihim Augustine Chinedu, Meludu Samuel Chukwuemeka, Onyenekwe Charles Chinedum
…ting 120 treatment naive individuals with active TB [26 (TB+HIV+) and 12 malaria parasite (MP) and TB (TB+MP+) co-infection, 82 HIV negative (TB+HIV−)], 26 Latent TB (LTB) and 105 apparently healthy control (AHC). TB infection was determined by Ziehl-Neelsen sputum smeared micros…
Daniel Bonnet, MD, France Mentre, PHD
… and T-SPOT.TB® for the diagnosis of latent tuberculosis in HIV infected antiretroviral naive patients: 80 originated from low TB prevalence countries, without any active TB; 80 HIV infected antiretroviral naïve patients originated from high TB prevalence countries, without any a…
S. T. Kavya, Avinash Hanbe Rajanna, Pradeep R. Bojja
HIV-TB Co-infection is increasing in the current scenario. TB is the leading cause of mortality in people living with HIV (PLHIV). HIV-infected persons have approximately an 8-times greater risk of TB than persons without HIV infection. HIV infection increases the risk of reactiv…
Irini Sereti, M.D.
…ho are also infected with the human immunodeficiency virus (HIV). However, not much is known about how these two infections affect each other. Some people who have HIV or TB infections develop health problems after they start taking either HIV or TB medications or both. These dru…
…etrics Abstract While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1 infection is exacerbated in macrophages exposed to TB-associated microen…
Maeva Dupont, Shanti Souriant, Luciana Balboa, Thien‐Phong Vu Manh, Karine Pingris, et al.
…etrics Abstract While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1 infection is exacerbated in macrophages exposed to TB-associated microen…
Keertan Dheda, MBChB, PhD
TB kills most people with HIV in Africa. TB is out of control. Radically different approaches to deal with the disease is therefor needed. It is known that intensified case finding works in high HIV prevalence environments. However, the poor performance of conventional diagnostic…
Augustine Chinedu Ihim, S. Meludu, CC Onyenekwe, Arthur Ebelenna Anyabolu, Comfort N Akujiobi
…ts consisting of 120 treatment naïve active TB patients [26 HIV co infected (TB+HIV+) and 82 TB+), 12 malaria parasite co-infected (TB+MP+)], 26 latent TB infected (LTB) and 105 healthy controls. Their body mass index (BMI) was calculated. Mycobacterium tuberculosis infection was…
Richard E. Chaisson, MD, Susan Swindells, MBBS
HIV-infected people have an increased risk of developing active tuberculosis (TB). At the time the study was designed, the standard course of treatment for TB was 6 to 9 months of isoniazid (INH).This study compared the safety and effectiveness of a 4-week regimen of rifapentine …
Ribhav Gupta, D.K. Winslow, Ronit Gupta, Sten H. Vermund
…are likely at higher baseline risk of Tuberculosis (TB) and HIV. Per ICE guidelines, TB screening is mandated on intake with no routine HIV testing protocols. This study explores TB and HIV epidemiology across ICE facilities from 2019-2023. Three month sliding average of monthly …
Robert Maina, Mathew Kinyanjui, Samuel Mwalili, Duncan Kioi Gathungu
…or that is considered to contribute to Kenya’s TB burden is HIV. TB is one of the most common opportunistic infections associated with HIV, and HIV infection increases the risk of developing active TB disease in individuals with latent TB infection. Due to their compromised immun…
World Health Organization
Aliyu Evuti Haruna, Nma Bida Alhaji
…und The co-infection of Mycobacterium tuberculosis (TB) and HIV poses a major global health threat, particularly in regions with high HIV prevalence. An estimated 4.4 million people are co-infected, with TB being a leading cause of AIDS-related deaths. While over 2 billion people…
K S Himani, Deepshikha Singh, Saachi Mehta, Achal Yawalkar, Abhimanyu Awasthi, et al.
HIV and Tuberculosis (TB) are the leading global causes of death among patients with infectious diseases. They contribute significantly to morbidity around the world because of their impact on shared immune defense mechanisms. Tuberculosis is an infection that exploits the vulner…
Chacon, Alexis
HIV and Tuberculosis (TB) co-infection place an immense burden on health care systems as they act in synergy to worsen disease prognoses. TB is the most common cause of death in people living with HIV (PLWH) and in turn, HIV is the most significant risk factor for progressing fro…
Kishore V. R. V. K., Hemasundar Rao M.
…as to screen the children who are household contacts of TB, HIV and TB -HIV patients and identify the children with the type of tuberculosis (Latent and symptomatic) and treat accordingly there by reducing the transmission of disease, as these children may become open cases in th…
Valeria Saraceni, MD, Richard E Chaisson, M.D., Betina Durovni, M.D.
…policy of widespread INH (Isoniazid) prophylaxis therapy in HIV-infected patients with access to antiretroviral therapy reduces the incidence of active TB disease in the HIV clinic population. Tuberculosis remains a major public health problem in Brazil. Approximately 35% of HIV…
Ling Chen, Lifan Zhang, Leidan Zhang, Liyuan Zheng, Jia Tang, et al.
…is (TB) is the leading cause of death in people living with HIV (PLWH) globally. Given the increased risk of TB infection, TB preventive therapy (TPT) is recommended for PLWH to prevent TB activation and to reduce relevant mortality. However, the implementation of TPT remains wea…
Clare Bristow, Uli Schwab
Introduction Patients with Human Immunodeficiency Virus (HIV) are at an increased risk of latent Tuberculosis (TB) reactivation. HIV TB concurrent infection increases mortality and reduces patient quality of life. Screening for latent TB allows treatment to commence, preventing r…