Showing 1–25 of 95 documents
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Chabala, Chishala
Children with HIV are highly susceptible to tuberculosis (TB) and often require concurrent antiretroviral treatment (ART) and antituberculosis therapy. However, rifamycins, the key drugs for TB treatment, significantly interact with many ART classes, necessitating adjustments to …
Perlman D, El-Sadr W
…months) for the treatment of pulmonary tuberculosis (TB) in HIV-infected patients. To compare toxicity, survival, and development of resistance in these two regimens. ORIGINAL: To compare the efficacy and safety of induction and continuation therapies for the treatment of pulmon…
Lauren A. Saag, Peter F. Rebeiro, Marcelo Cordeiro‐Santos, Afrânio Lineu Kritski, Bruno B. Andrade, et al.
…redictor of poor tuberculosis (TB) treatment outcomes among HIV-negative populations, but the relationship has not been well studied in the context of HIV. We examined the association between HIV and weight change during the first two months of anti-tuberculosis treatment, and al…
Anushka Naidoo, PhD, Kelly Dooley, MD, Kogieleum Naidoo, PhD
…Tenofovir alafenamide 25mg (Biktarvy®) dosed twice daily in HIV-1 infected, ART-naïve patients with TB co-infection receiving a rifampicin-based tuberculosis (TB) treatment regimen. This study will assess the activity of Bictegravir and dolutegravir-containing ART regimens in pat…
Cielo Ríos, Marcela Vásquez Rojas, Martha Lucía Serrano, Alexandra Porras, Ricardo Luque, et al.
…stigated the delays in the diagnosis of tuberculosis and/or HIV, their treatment initiation, and factors associated with each delay. All drug-susceptible tuberculosis cases diagnosed in 2014 and 2015 in Colombia, with a confirmed diagnosis of HIV were included. A total of 1909 pa…
Eric Nuermberger, MD
…(TBD) during 72 weeks of follow-up among people living with HIV (PLHIV) and high-risk Close Contacts (CC) of adults with Drug Susceptible (DS) or Rifampin Resistant (RR) TB. Treating adult, adolescent, child, and pregnant close contacts (CCs) of drug-sensitive tuberculosis (DS-T…
Aner H Khan
… million TB fatalities among Human immune deficiency virus (HIV)-negative people and 208, 000 deaths among HIV-positive people. Literature indicated that treatment adherence for coinfections diseases is difficult due to the complexity, low tolerability, and extended duration of c…
Silvia S. Chiang, Helen E. Jenkins
…escents infected with TB, those <5 years old and those with HIV coinfection have a higher risk of death.2–4 Not only have few researchers quantified the impact of antiretroviral therapy (ART) regarding those with coinfected with HIV,4–6 there are important gaps in our overall kno…
Oriekot Anthony, Senai Goitom Sereke, Felix Bongomin, Samuel Bugeza, Zeridah Muyinda
…ty (n=118, 71.7%) of the participants were seronegative for HIV. Overall, 5/165 (3%) participants had normal CXR. There was no statistically significant difference in the proportion of participants with consolidations (74.8% versus 88.5%; p – 0.203), bronchopneumonic opacities (5…
Putri Immi Rizky Budiyani, Ratna Djuwita, Renti Mahkota, Dwi Handayani
Tuberculosis and HIV are serious health issues that can significantly impact an individual's immune system by evading immune monitoring functions. Research on TB-HIV treatment success, especially in DKI Jakarta province, is still limited. This study aims to assess the treatment s…
National Institute of Allergy and Infectious Diseases (NIAID)
…l suppression when dosed with rifapentine (RPT) 1200 mg for HIV-associated TB. This is an open-label, single arm, phase II, multicenter PK study to investigate the effect of daily RPT 1200 mg on DTG exposure in participants with HIV-associated TB. Adults with HIV with newly diag…
Kuppli Sai Sushma, Devi Madhavi Bhimarasetty, Siva Kumar Lotheti
… treatment of Drug sensitive TB, started initially among TB-HIV co-infected patients in 2017. The present study was taken up to assess the treatment outcomes of Tuberculosis among TB-HIV co-infected patients and certain factors related to the poorer outcome of the treatment. An O…
Jason Farley, PhD, MPH, ANP-BC, Denise Evans, PhD, Norbert Ndjeka, MBChB
…-based outpatient sites among RR-TB patients, regardless of HIV co-infection, as determined by a successful treatment outcome \[H1\]. 2. The proportion of SAEs identified will not significantly differ by blinded, independent review \[H2\]. 3. Patient associated catastrophic costs…
Urooj Ahmad, Anab Arshad, Sara Jadoon, Shahana Saba Salih, Hafsa Ahmed, et al.
…38,723 patients. In 2815 Tuberculosis patients screened for HIV, 4 drug-susceptible and 5 drug-resistant cases were positive for HIV. 8.41% of drug-resistant TB patients were diabetic. Conclusion: The frequency of TB cases is high in Khyber Pakhtunkhwa, especially among 15-24-yea…
Kamatam Meghana, Dollu Rakshitha, Vurugonda sreshta, Kaleru Purnachander
…rculosis) was defined by 1980's since then the emergency of HIV and escalation of Drug sensitive (DS-TB)forms of TB have presented new challenges.To face these challenges, achieve goals like shortening DS -TB treatment improving DR-TB treatment and making combined TB -HIV therapy…
Dmytro O. Butov, Tetyanas S Butova
… meningoencephalitis (TM) and human immunodeficiency virus (HIV) co-infection in the intensive phase of treatment. Methods: Fifty-four patients with TB / TM and HIV co-infection were enrolled in this study. Group 1 included 23 patients treated with E and H i/v, while rifampicin a…
A.O. Temitayo-Oboh, Ayotunde Sherif Azees, J.O. Amin, A.R. Salam, M.M. Fasiku
…ere 83.2% and 43.7% respectively. TB patients with negative HIV status were about two times more likely to have successful treatment outcomes (OR=1.86, 95%CI=1.20-2.88).
 Conclusion: The TSR and cure rate obtained in this study were below the national targets set by the Worl…
Marissa Russell
…ups. * H56:IC31 (investigational vaccine) * Placebo 900 HIV-negative adults with a diagnosis of drug susceptible pulmonary TB are planned to be included, recruited from TB clinics with established relationships to the trial sites at the start of their TB treatment. 5 study…
Abdulrhman Awadh Alharbi, Ibrahim Muhammad Al-Arej, Abdullatif Suliman Alsayegh, Meshal Ibrahim Zaid Al Owias, Bader Sayah Alanezi
… particularly in low- and middle-income countries and among HIV-positive individuals. TB transmission occurs primarily through inhaling aerosolized droplets from an infected person, leading to potential disease progression. Risk factors for TB include close contact with infected …
Dmytro Butov, Yurii Feshchenko, Mykhailo Kuzhko, Mykola Gumenuik, Yurko Kateryna, et al.
…usceptible pulmonary TB with TB meningoencephalitis(TM) and HIV co-infection in the intensive phase of treatment. <b>Material and Methods:</b> 54 patients with TB/TM and HIV co-infection were enrolled in this study. Group1 included 23 patients with TB/TM and HIV co-infection trea…
Grace Kansiime, Abinet M. Aklilu, Joseph Baruch Baluku, Farah Yasmin, Michael Kanyesigye, et al.
…I in the immediate post-TB diagnosis period in Uganda, a TB/HIV-endemic country in sub-Saharan Africa. Methods We included patients enrolled in an observational cohort study of adults diagnosed with drug-susceptible TB followed longitudinally. Adults (≥18 years) without known kid…
Felipe Ridolfi, Gustavo Amorim, Lauren Peetluk, David W. Haas, Cody Staats, et al.
…dictors of TB-ADR included concomitant medication (CM) use, HIV-status, glycated hemoglobin (HbA1c), age, body mass index (BMI), sex, substance use, and TB drug metabolism variables (e.g., NAT2 acetylator profile). Bootstrapped backwards selection was used to develop the models. …
Dereck Tait, MBChB
… immunogenicity profile of escalating doses of AERAS-456 in HIV-negative subjects recently treated for drug-susceptible pulmonary TB will be investigated. The study will be conducted at three sites in South Africa. This study will be the first evaluation of AERAS-456 in subjects…
Edwin Nuwagira, Stellah Mpagama, Conrad Muzoora, Joseph Mugerwa, Mike Ssemusu, et al.
…m are from low and middle income settings. Malnutrition and HIV remain the leading risk factors for TB infection. Despite the advocacy and awareness about TB, post-TB morbidity and disability have been neglected by TB programs in Africa. We have previously showed that HIV-positiv…
Argita D. Salindri
…rs such as pre-existing T2DM, human immunodeficiency virus (HIV), and hepatitis C co-infections on post-TB health has not been assessed. To evaluate the relationship between comorbidities and post-TB treatment health, we conducted three observational studies (two retrospective an…