Showing 1–7 of 7 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Ying Zhang, PhD, Wenhong Zhang, PhD,MD
Multidrug resistant tuberculosis (MDR-TB) is difficult to treat and raises a great challenge to TB control program. That pyrazinamide can shorten the course of treatment and facilitate bacilli clearance has been proved recently. In 2011, WHO recommended to use pyrazinamide throug…
Sarah Meredith, MD, Andrew Nunn, PhD
… being impacted by the emergence of multidrug resistant TB (MDR-TB). MDR-TB refers to TB that is resistant to at least isoniazid and rifampicin. These are the two most powerful first-line drugs used to treat pulmonary TB. MDR-TB usually develops while a person is taking TB treatm…
Keertan Dheda, MBChB
…been compounded by the emergence of multidrug-resistant TB (MDR-TB), which constitutes resistance to the two most potent anti-tuberculous drugs, namely rifampicin and isoniazid . XDR-TB refers to resistance to rifampicin, isoniazid, any fluoroquinolone, and any second line inject…
Lorenzo Guglielmetti, MD, Carole Mitnick, Sc.D
…l evaluating the efficacy and safety of five new, all-oral, shortened regimens for multidrug-resistant tuberculosis (MDR-TB). This is a Phase III, randomized, controlled, open-label, non-inferiority, multi-country trial evaluating the efficacy and safety of new combination regim…
Lorenzo Guglielmetti, MD, Carole Mitnick, Sc.D
…al evaluating the efficacy and safety of two new, all-oral, shortened regimens for multidrug-resistant tuberculosis (MDR-TB) with fluoroquinolone resistance. This is a Phase III, randomized, controlled, open-label, multi-country trial evaluating the efficacy of new combination r…
Aung Kya Jai Maug, MD
… toxicity, and allows early switch to specific treatment of MDR-TB without using Cat. 2 retreatment regimen \- General study design: This open label, randomised clinical trial is intended as a pilot study on the efficacy and safety of high-dose rifampicin and feasibility and add…
Cynthia R. Giver, Pamela A. Shaw, Helen A. Fletcher, Deepak Kaushal, Garcia Pamela, et al.
…tes for multi- and extensively-drug resistant tuberculosis (MDR-TB, XDR-TB) are dismal, highlighting the urgent need for new drugs. Ratios of myeloid to lymphoid cells are important predictors of TB disease susceptibility and vaccine efficacy. Imatinib mesylate (Gleevec), a cance…