Showing 1–25 of 200 documents
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National Institute of Allergy and Infectious Diseases (NIAID)
The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC) treatment for tuberculosis meningitis (TBM). Rationale: T…
Xueyi Chen, Carlos E Ruiz-Gonzalez, Yuderleys Masias-Leon, Mantej Singh, Oscar J Nino-Meza, et al.
…ains unexplored.Figure 1.Evaluation of rifamycin-containing regimens in the mouse model of TB meningitis.(A) Mice were infected intraventricularly via Burr hole using a syringe and stereotaxic instrument, treatment were initiated two weeks after (designated as day 0) and continue…
Soumya Swaminathan, MD MNAMS
…l trial to assess the efficacy of short course intermittent regimens for the treatment of HIV-associated tuberculosis Phase: Phase III trial Population: 300 HIV positive patients with tuberculosis. Number of Sites:Four 1. Tuberculosis Research Centre, Chennai 2. Government Ge…
Camilo A. Ruiz-Bedoya, Filipa Mota, Elizabeth W. Tucker, Farina J. Mahmud, Clara Erice, et al.
…atment in animals receiving high- or standard-dose rifampin regimens (Fig. 3). Whole-brain PET and immunolabeling demonstrated spatially compartmentalized inflammation, vascular leak and rifampin exposures (Fig. 4). Longitudinal imaging in the same animals showed a 40% decrease i…
Soumya Swaminathan, MD, PR Narayanan, PhD
…icacy of two different once daily anti-retroviral treatment regimens along with anti-tuberculosis treatment in patients with HIV-1 and tuberculosis - Randomized Controlled Clinical Trial Phase: Phase III trial Population: 180 HIV-1 positive patients with tuberculosis Number of…
Rovina Ruslami, PhD
…nts with TB meningitis will die. With the current treatment regimens, TBM is fatal in approximately 30-50% of cases, and responsible for severe disability in a similar proportion of survivors. Worldwide, Indonesia the third highest case load of tuberculosis with an estimated 500…
Eliana Bicudo, Naira Bicudo, Clarisse Rocha, Joyce Cabral, Gustavo Bicudo
…se infections can be complex, requiring combined antibiotic regimens, oral and intravenous, for prolonged periods, and antimicrobial resistance often poses a challenge. Outpatient Parenteral Antimicrobial Therapy (OPAT) has proven to be an effective approach, allowing patients to…
Mengmeng Zhang, Ming-Gui Wang, Jian‐Qing He
Background Tuberculous meningitis is difficult to diagnose and is associated with high mortality. Recently, several studies evaluated the intensified regimen containing higher dose rifampin to treat tuberculous meningitis. However, this topic remains to be concluded. Therefore, t…
Surendra K Sharma, MD,PhD
Tubercular pleural effusion is the second most common form of extrapulmonary tuberculosis (EPTB) seen in clinical practice after tuberculosis (TB) lymphadenitis. It is common that after complete treatment of the patient with tubercular pleural effusion with six months of the shor…
Svetlana Degtyareva, Т. А. Кузнецова, В. Н. Зимина
…case demonstrates the clinical efficacy of modern treatment regimens, good compatibility with other drugs and management of adverse events without treatment interruption.
Connie A. Haley, David Ashkin, Charles A. Peloquin
…quires prolonged treatment using less effective, more toxic regimens. Recent trials demonstrated that the all-oral six-month “BPaL” regimen, Bedaquiline, Pretomanid and Linezolid, is 90% effective. In these trials, linezolid-induced hematologic and neurologic toxicity was high us…
M. V. S. Subbalaxmi, Suneel Kumar Bagadi, Sandeep Baddepuram, Radhika Soanker
Stevens–Johnson syndrome (SJS) and hepatitis are serious adverse drug reactions following the administration of anti-tuberculosis treatment (ATT). Here, we report a case of a young woman who developed hepatitis and SJS following ATT. Identifying the culprit drug and tailoring the…
Indian Council of Medical Research
Tuberculous meningitis (TBM) is the most lethal form of extra pulmonary tuberculosis. This devastating disease kills almost a third of its sufferers and disables a significant proportion of the survivors. TBM poses one of the most difficult diagnostic and therapeutic challenges i…
Surendra Kumar Sharma, Vishwanath Upadhyay, Alladi Mohan
…12 months after culture conversion45. Suggested antibiotics regimens for adults with MAB-pulmonary disease have been adequately described previously in the guidelines459. Expert consultation should be obtained while treating MAB45. Treatment for clarithromycin-sensitive MAB-pulmo…
Colette Biro, Corinne Muirhead
…ilities and provider experience facilitate chosen treatment regimens. MABSC infections are difficult to treat due to intrinsic and acquired resistance patterns, limited oral antibiotic options, and medication toxicity.2 Optimal treatment duration is not known and people who do no…
Heather Wang, Mohammad Mahdee Sobhanie, Courtney Nichols
…. Breakdown of antibiotic classes used in initial treatment regimens for dNTM-infected patients, along with antibiotics that caused patient intolerances. For each antibiotic class that caused intolerance, average time to develop intolerance listed. Conclusion Treatment of dissemi…
Tosin Ogunsiakan, Kristen D. Fajgenbaum, Thomas B. Montgomery, Gautam M. Phadke, Kiran Gajurel
INTRODUCTION Mycobacterium kansasii (MK) is an environmental nontubercular mycobacterium (NTM) that can occasionally cause human infections. The incidence of MK infection varies by geographic location, but in general, it is much less prevalent than Mycobacterium avium complex (MA…
Marcelo Radisic, Natalia Pujato, Pablo M. Bravo, Roxana Del Grosso, Martin Hunter, et al.
…mTOR/calcineurin inhibitors (CNI) led to use of alternative regimens for TB treatment in this group of patients. Results obtained in TB treatment with RFP-free regimens in K/KP TX patients are presented. Methods: Retrospective review of confirmed TB cases in K/KP Tx patients. (Ja…
Armine Galstyan, Borisov Se, Michail Sinitsyn, Diana Ivanova, Ludmila Slogodskay
<b>Background:</b> The use of Bedaquiline-containing regimens improves outcomes of treatment, but the safety of bedaquiline (Bdq) in HIV patients is not enough studied. The aim was to analyze the frequency and severity of adverse drug reactions (ADRs) during bedaquiline-containin…
Dhruv Gandhi, Viren Amesur, Aditi Gupta, Minnie Bodhanwala, Ira Shah
A bstract Background: Conventional first-line regimens for pediatric central nervous system tuberculosis (CNS-TB) have been associated with poor clinical outcomes. In view of their bactericidal effect and high penetration rates into the CNS, ethionamide and ofloxacin may improve …
Zachary A. Yetmar
…apolated from nontransplant populations. Typical antibiotic regimens commonly have drug-drug interactions with usual maintenance immunosuppression and carry many potential adverse effects. Third, transplant recipients are at risk for concurrent pathogens, which can complicate NTM…
Nabaneeta Dash, Maura Manion, Sarah L. Silverberg, Ian Kitai
Worsening of clinical, radiologic or laboratory parameters while receiving appropriate antituberculous therapy (ATT) is broadly classified as a “paradoxical reaction” (PR). In this review, we refer to PR as a dysregulated inflammatory response following the institution of appropr…
Dario Cattaneo, Agostino Riva, Paola Columpsi, Giuseppe Lapadula, Carlo Fìlice, et al.
…rom Botswana treated with dolutegravir-based antiretroviral regimens. Interestingly, only 53% of the 739 TB/HIV coinfected patients who received rifampicin- and dolutegravir-based regimens received the twice daily dolutegravir dosing suggested by international guidelines (and for…
Shireen Yan Ling Tan, Jamie Bee Xian Tan, Dorothy Hui Lin Ng
…of poor companion antibiotics, such as macrolide-containing regimens without amikacin. Continuous surveillance and research will be vital in addressing this emerging public health threat. Acknowledgement We thank our research coordinator Ms Charlene Suk Teng Cheong, Department of…
Trina Sarkar, Niccolò Riccardi, Haresh D Wagh, Zarir Udwadia
Sir, Rifampicin (RIF) is a key drug in the treatment of drug-susceptible tuberculosis;[1] however, RIF associated adverse reactions pose a threat to effective anti-tuberculosis treatment.[2] Thrombocytopenia due to RIF is well known since 1970, is a rare, immunologically mediated…