Showing 1–25 of 120 documents
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Christoph Lange, Dumitru Chesov, Olha Konstantynovska, Anna-Maria Mandalakas, Zarir Udwadia
Until the coronavirus disease 2019 pandemic, tuberculosis had been the leading cause of death by an infectious disease worldwide. According to the WHO, there were 1.41 million deaths attributed to tuberculosis in 2019. Globally, the burden of tuberculosis is asymmetrically distri…
Srabani Banerjee, Melissa Severn
Tuberculosis (TB) is one of the top 10 causes of death, worldwide. Worldwide 10 million people developed TB in 2017, (i.e.,133 cases per 100,000).– However, only 6.4 million cases were reported to WHO, indicating that 36% of cases were undiagnosed or not reported. According to a …
Yiheyis Genetu, Bethelhem Belay, Workeabeba Abebe
Background: Approximately 81% of all childhood tuberculosis cases occur among 22 high-burden countries and Ethiopia ranks eighth among these high burden countries. The GeneXpert Mycobacterium tuberculosis DNA and resistance to rifampicin (MTB/RIF) test can detect pediatric tuberc…
Zahra Hasan, Sadia Shakoor, Rumina Hasan
…ountries (LMICs) with a high burden of infectious diseases. Tuberculosis (TB), a major source of morbidity and mortality worldwide, was further exacerbated by the COVID-19 pandemic, resulting in up to 1.5 million deaths in 2020 [[1]WHOGlobal tuberculosis report 2021. World Health…
Ana Alvarez, Mobeen H. Rathore
…ies have led to several new recommendations in the areas of diagnosis and treatment of pediatric tuberculosis in the past few years. Due to the low incidence of tuberculosis in the United States, many primary care providers may not be familiar with these new recommendations.After…
Hebert Dedehouanou, Yazid Taïrou Toure, Laurence Yehouenou
The diagnosis of bacteriologically confirmed pulmonary tuberculosis in Benin and in other developing countries relies on the search for acid-fast bacilli through microscopy despite its limited sensitivity. The objective of this study is to evaluate the contribution of the Xpert t…
I. B. Kulikova, I. А. Vаsilyevа, А. И. Казаков, Н. И. Клевно, С. А. Стерликов, et al.
The objective: to evaluate tuberculosis situation in the Russian Federation among children aged 0-17 years based on the analysis of key epidemiological rates from official statistics for 2023. Subjects and Methods. Information from official statistical surveillance forms was stud…
Christoph Lange, Professor
…l diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with respiratory tuberculosis. Once diagnosed, the investigators will use target next generation sequencing t…
Ambreen Ahmad, Islam Gul, Muhammad Idrees, Ansaar Hussain
…ine the performance of Genexpert in detecting Mycobacterium Tuberculosis in children comparedwith microscopy and MGIT culture and determining the sensitivity pattern of Mycobacterium Tuberculosis in childrenat Hayatabad Medical Complex, Peshawar.Study Design: This is cross-sectio…
Philippe Ngwala Lukanu, Papy Lusameso, Angel Matota Shoma, Jeanne Tshibungu, Isabelle Kufundu, et al.
Background: A late diagnosis of tuberculosis has serious consequences for the spread and outcome of the disease. Delayed diagnosis is an important indicator of the quality of a tuberculosis control program. The aim of this study is to identify the determinants of delay in tubercu…
Melchor VG Frias, IV, MD, Anjanette Reyes-De Leon, MD, Louvina van der Laan, MD
…id plus an optimized background regimen (OBR) of other anti-tuberculosis drugs in pediatric participants who completed Study 242-12-232 (NCT01856634). This study will assess the safety, tolerability, pharmacokinetics, and efficacy of delamanid plus an optimized background regime…
Mohamad Zacky Amirullah, Sudarto Sudarto, Zen Ahmad, Bryan Arista Hartono
Rifampicin-resistant tuberculosis remains a major global health challenge, particularly when occurring as primary resistance in patients without prior tuberculosis treatment. Tuberculosis drug resistance incidence in Indonesia expected 2.2% primary and 25% with prior anti-tubercu…
Rabyya Jameel, Naima Mehdi, Nadia Majeed, Aizza Zafar, Anum Tahir, et al.
Rifampicin is a primary anti-tuberculosis medication. Diagnosing multidrug-resistant tuberculosis (MDR-TB) remains a persistent challenge when examining both pulmonary and extra-pulmonary samples. Rapid detection of rifampicin resistance is essential for the timely treatment and …
Mostofa Showkat Imran
Background: Tuberculosis (TB) is a common condition all over the world but more common in developing countries like Bangladesh38. This is second only to HIV/AIDS as the greatest killer worldwide due to a single infectious agent. In 2013, 9 million people fell ill with TB and 1.5 …
Hannah-Lena Schäfer, Michael Barker, Peter Follmann, Annette Günther, André Hörning, et al.
Delay in diagnosing multidrug-resistant tuberculosis (MDR-pTB) in children prolongs time to effective treatment. Data on risk factors for pediatric MDR from low-incidence countries are scarce. Retrospective nationwide case–control study to analyze MDR-pTB cases in Germany between…
Jeffrey Hafkin, MD
The purpose of this trial is to determine the pediatric dose of delamanid that is equivalent to the adult dose already shown to be effective against multidrug-resistant tuberculosis. This trial will investigate the pharmacokinetics (PK) and safety of delamanid administered for 1…
S. Maïga, Ali Moussa ML., Tagne M.L., A. Valia, N. Gilbert, et al.
Tuberculosis is a highly contagious infectious disease. It poses a major public health problem. While pulmonary forms are the most frequent in our countries, extra-pulmonary forms are rare in our daily practice. This may be due to their rarity, on the one hand, and to the difficu…
І. В. Ліскіна, С. Д. Кузовкова, Л. М. Загаба, О.D. Nikolaeva
Objective — to clarify the prevalence of tuberculosis infection in HIV-positive inpatients of the TB hospital for 2014—2018 and features of its diagnosis in the affection of the chest cavity organs.Materials and methods. The method of retrospective analysis was used to process me…
Efyluk Garianto, Barkha Agung Priyanto, Benedictus Sebastian Aldorino, Berlian Rutana Pratiwi, Bima Aji Lazuardi, et al.
Introduction: Tuberculosis (TB) is a human disease caused by Mycobacterium tuberculosis. The bacteria is a rod-shaped and acid-resistant, hence it is also known as acid fast Bacilli. The disease mainly affects the lungs, making pulmonary disease the most common presentation of Tu…
И. С. Долгополов, O. B. Federiakina, O. M. Volzhenina, G. G. Erokhina, K. A. Leonov, et al.
Congenital tuberculosis is a fatal disease in the absence of treatment. The diagnosis is difficult due to polymorphic and nonspecific symptoms in neonates, as well as the lack of alertness of neonatologists and pediatricians. Less than 500 confirmed cases of congenital tuberculos…
Vikas Marwah, Gaurav Bhati, Robin Chaudhary, Anmol Sharma
Background: Pulmonary tuberculosis (PTB) is an established cause of arterial and venous thrombosis. With the rising incidence of multidrug-resistant tuberculosis (MDR TB), which has a prolonged treatment course, pulmonary thromboembolism in such cases further complicates the trea…
О. М. Raznatovska, A. S. Moskaliuk, Тетяна Анатоліївна Грекова, L. I. Chernyshоva, O. O. Pushnova, et al.
…th Organization (WHO) reports an unknown contact history of pediatric tuberculosis (TB), especially in children younger than 5 years old. Tracing pediatric household contacts of patients with multidrug-resistant TB (MDR-TB) is considered to be a highly effective intervention for …
Dhruv Gandhi, Ira Shah
…Xpert Ultra, and Xpert MTB/XDR, are critical for diagnosing pediatric tuberculosis (TB) and detecting drug resistance. However, rifampicin indeterminate (RI) results, particularly in samples with trace Mycobacterium tuberculosis (MTB) load, pose a clinical challenge. Current guid…
Hannah Schäfer, Michael Barker, Peter Follmann, Annette Günther, Petra Kaiser‐Labusch, et al.
<b>Background:</b> Diagnosis and treatment of paediatric tuberculosis resistant to both isoniazid and rifampicin (MDR-pTB) remain challenging due to paucibacillary disease, low sensitivity and specificity of diagnostic tools and frequently changing guidelines <b>Aims and objectiv…
Titiek Sulistyowati, Deby Kusumaningrum, Eko Budi Koendhori, Ni Made Mertaniasih
Background: Tuberculosis continues one of the major challenges to global health. Mycobacterium tuberculosis complex can affect any organ other than the lung parenchyma, include central nervous system. The mortality rate of tuberculous meningitis (TBM) are high worldwide with up t…