Showing 1–25 of 90 documents
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Letícia Baltar Sobreira, Paula de Souza Silva Freitas, Luciana de Cássia Nunes Nascimento, Anne Caroline Barbosa Cerqueira Vieira, Carolina Maia Martins Sales, et al.
…cessively resistant and multidrug resistant tuberculosis in pediatric patients. Methods: this is a scope review of the literature, with a guiding question: “What is the scientific evidence on multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis in…
Yulia Khokhlova, М. Ф. Губкина, Natalya Yukhimenko, I. Yu. Petrаkovа, С. С. Стерликова
… on the use. To decide on the safety of fluoroquinolones in pediatric TB, it is important to assess benefits versus risks of adverse events. <b>Aim:</b> To study efficacy and safety of fluoroquinolones in the treatment for MDR/XDR TB in children. <b>Materials and methods:</b> We …
SushantSatish Mane
…is (TB) is a grave problem, with nearly one-third of global pediatric TB cases being from India. In 2020, approximately one lakh TB cases (0–14 years of age) were reported to the National TB Elimination Program (NTEP), with around 1.4 lakh cases in the 15–18 years age group.[1] O…
Gaurav Sharma, Bharti Malhotra, P. J. John, Shipra Bhargava
…TB) and its drug resistance profile by molecular methods in pediatric patients suspected of pleural tuberculosis. Children ≤ 15 years of age suspected of pleuritis were enrolled in this study. Total 176 pleural fluid samples were collected from January to June 2018 and tested for…
Ambreen Shaikh, Camilla Rodrigues
…mmended Xpert Ultra (Cepheid) testing of stool in suspected pediatric pulmonary TB. In comparison to a reference standard, the sensitivity and specificity of stool Xpert Ultra testing in children with presumptive TB are 67% and 99%, respectively.4 The sensitivity is higher (79%) …
Peter J. Holmberg, Zelalem Temesgen, Ritu Banerjee
…em Temesgen, MD† 3. Ritu Banerjee, MD, PhD‡ 1. *Division of Pediatric Hospital Medicine, Department of General Pediatric and Adolescent Medicine, and 2. †Division of Infectious Disease, Mayo Clinic, Rochester, MN 3. ‡Division of Pediatric Infectious Diseases, Department of Pediat…
Dhruv Gandhi, Viren Amesur, Minnie Bodhanwala, Ira Shah
Abstract Background Pediatric central nervous system tuberculosis (CNS-TB) accounts for 10% of all pediatric TB cases in India and carries the highest morbidity and mortality. However, data on pediatric drug resistant (DR) CNS-TB remains scarce. Regional data from Mumbai suggests…
Gaurav Sharma, Bharti Malhotra, Paget John, Shipra Bhargava
…d to detect the incidence of tuberculous meningitis (TM) in pediatric patients using GenoType MTBDRplus, GenoType MTBDRsl, and Mycobacteria Growth Indicator Tube (MGIT). Additionally, it aimed to evaluate the utility of GeneXpert MTB/RIF assay in the detection of Mycobacterium tu…
E. A. Krushinskaya, Л. В. Панова, V. V. Bereznitskaya, E. S. Ovsyankinа, О. А. Пискунова
…to treatment with two-stage surgery and consultation from a pediatric cardiologist allowed completing the main course of TB treatment and achieving successful treatment outcome.
Muhammad Kashif Munir
…which improved sensitivity, particularly in smear-negative, pediatric, and extrapulmonary cases1. Yet the most significant recent milestone has been the introduction of GeneXpert MTB/XDR. This assay detects resistance not only to rifampicin and isoniazid but also to fluoroquinolo…
E. S. Ovsyankinа, Л. В. Панова
…emotherapy and is an urgent problem at the present stage of pediatric phthisiology.
Unnati Desai, Jyotsna Joshi, Parikshit Thakare, Ketaki Utpat
…1 years; there were 57 males. Mean body weight was 41.8 kg. Pediatric patients (age 12-17) constituted 13%. All the patients had pulmonary TB. Of the 100 cases, 80 were Category IV failure; 5% were defaulters of Category IV; and 15% were treated with second-line drugs adequately …
Majani Edward, Ameh Wisdom Owoicho
…lexities, particularly for difficult-to-diagnose forms like pediatric and extrapulmonary TB (including central nervous system TB), the alarming rise and spread of drug-resistant TB (MDR-TB and XDR-TB), the pervasive impact of social stigma on care-seeking and adherence, and the l…
Parissa Farnia, Ali Akbar Velayati
… is indicated as a part of combination therapy in adult and pediatric patients (≥5 years, weighing ≥15 kg) with pulmonary MDR-TB. BDQ has become central to MDR-TB therapy and is also a part of the shorter and oral regimen. Based on the result of a systematic review and a meta-ana…
Dhruv Gandhi, Shatakshi Garg, Sonal Patil, Dhruv Mamtora, Ira Shah
…etects resistance to multiple drugs, but its performance in pediatric TB remains understudied. The aim of this study is to evaluate the agreement between Xpert MTB/Rif or Ultra, Xpert MTB/XDR, LPAs, and 3-drug pDST for detecting antitubercular drug resistance in children.Table 1:…
Francesca M Conradie
BEAT Tuberculosis is a phase 3, open label, multi-centre, randomized controlled trial. The purpose of this trial is to compare the efficacy and safety of a Study Strategy consisting of 6 months of bedaquiline (BDQ), delamanid (DLM), and linezolid (LNZ), with levofloxacin (LVX) an…
Anita Mesić, Ine I. Decuyper, Sadiqqullah Ishaq, Taiba Azizi, Fazal Hadi Ziamal, et al.
Clinical trials, evaluating 9-month/7-drug and 6-month/4-drug all-oral rifampicin-resistant tuberculosis (RR-TB) treatment regimens showed that these are at least as effective and safer than previously used longer and injectable-containing regimens [1–4]. Findings directly inform…
Malik Zohaib Ali, Taru S. Dutt, Amy L. MacNeill, Amanda Walz, Johnathan Patterson, et al.
The Nix-TB clinical trial evaluated a new 6-month regimen containing three-oral-drugs; bedaquiline (B), pretomanid (Pa) and linezolid (L) (BPaL regimen) for treatment of tuberculosis (TB). This regimen achieved remarkable results as almost 90% of the multidrug resistant (MDR) or …
Giller Db, В.В. Короев, O.Sh. Kesaev, G. V. Shcherbakova, А. А. Попова, et al.
Treatment of cavernous or fibro-cavernous pulmonary ТВ, especially multidrug-resistant (MDR-TB) or extensively drug resistant TB (XDR-TB), in children is a huge challenge. At the same time, the incidence of drug-resistant TB is growing throughout the world year after year. We ana…
Mahaman Laouali Harouna Amadou, Ibrahim Maman Lawan, Abdoulaye Ousmane, Abdoul Kadir Ibrahim Mamadou, AMADOU, Oumarou, et al.
Aim of study: To describe the clinical, therapeutic and evolutionary profile of patients followed for rifampicin-resistant pulmonary tuberculosis (RR-TB) at the Regional Hospital Centre (RHC) of Maradi (Niger) from 2014 to 2018. Methods: We conducted a retrospective and descripti…
Olena Ivanova, Dragoș Băiceanu, Abhishek Bakuli, M. Vogel, Cristina Popa, et al.
Abstract Background Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) patients are likely to suffer from TB-related morbidity, social and economic consequences during and beyond anti-TB treatment. The aim of this study is to describe clinical and so…
О. М. Raznatovska, V.I. Petrenko, О.S. Shalmin, R.M. Yasinskyi, A.V. Fedorec, et al.
We present our own observation of the multifocal tuberculosis with pre-extensive drug resistance (pre-XDR-TB) development in a patient who was treated in the pulmonary tuberculosis department No. 2 of the Zaporizhzhia’ regional phthisio-pulmonology clinical treatment and diagnos…
Bolyskhan Baigabyl, Bolor Rash, Oyunchimeg Adilaa, Yanjindulam Purevsuren, Dorjderem Radnaa
<b>Background:</b> The prevalence of drug resistance is a major challenge to TB control, and extensively drug-resistant TB (XDR-TB) forms are high mortality, highly costly to treat, and most likely to a disability, but there is a lack of research on the results in our country. <b…
Assefa Hamato Kebede, Hassen Mamo Idris
Abstract Background : Tuberculosis (TB) is one of the oldest diseases known and the spread of drug-resistant TB poses significant challenges in TB control and eradication program globally, and also the distribution varies geographically worldwide and within the countries. Lack of…
M.І. Sakhelashvili, І.L. Platonova, O.I. Sakhelashvili–Bil, Z.I. Pіskur
Introduction. Against the backdrop of multiple and widespread drug resistance of Mycobacterium tuberculosis (MDR-TB), there has been a significant decline in the effectiveness of treatment of tuberculosis (TB) patients in Ukraine and globally. Therefore, in recent years, new anti…