Showing 1–25 of 200 documents
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Kelly Walblay, Tristan D. McPherson, Elissa Roop, David F. Soglin, Ann Valley, et al.
…evalence of C. auris colonization has not been described in pediatric populations in the United States, and limited data exist on CPO colonization in children outside intensive care units. The Chicago Department of Public Health (CDPH) conducted a PPS to assess C. auris and CPO c…
Mandira Chakraborty, Sayani Sardar, Rituparna De, Malabika Biswas, Maria Teresa Mascellino, et al.
…tance patterns of pathogens causing infections in adult and pediatric patients in the ICUs of a tertiary care hospital in Kolkata, India. A cross-sectional, retrospective study was conducted from January 2022 to October 2022 on a total of 139 adult and 146 pediatric patients. Dep…
Jeffrey Hafkin, MD
The purpose of this trial is to determine the pediatric dose of delamanid that is equivalent to the adult dose already shown to be effective against multidrug-resistant tuberculosis. This trial will investigate the pharmacokinetics (PK) and safety of delamanid administered for 1…
Ahmed R. Rezk, Somaia Abdelhammed Bawady, Nashwa Naguib Omar
…orldwide threat in intensive care units particularly in the pediatric intensive care units with a major cause of morbidity and mortality among this age group. The aim of the study is to determine the prevalence and risk factors predisposing to multidrug-resistant organisms (MDROs…
Ouissal Aissaoui, Lina F. Berrada, O. Ettouki, Samira Kalouch, K. Yaqini, et al.
…tion of patients with Raoultella terrigena infection in the pediatric intensive care unit, and therefor highlight the challenges physicians face while managing these multi drug resistant emergent pathogen. Methods: We conducted a retrospective study, over a period of 4 months (01…
Vivek Viswanathan
… The intersection of sociodemographic factors with DR-TB in pediatric populations remains understudied, especially in rapidly urbanizing environments. Objective: To investigate the relationship between sociodemographic factors and DR-TB in pediatric patients at a tertiary care ce…
Melchor VG Frias, IV, MD, Anjanette Reyes-De Leon, MD, Louvina van der Laan, MD
…ackground regimen (OBR) of other anti-tuberculosis drugs in pediatric participants who completed Study 242-12-232 (NCT01856634). This study will assess the safety, tolerability, pharmacokinetics, and efficacy of delamanid plus an optimized background regimen in pediatric partici…
Maika Kamille Mortel, Ana Patricia Alcasabas, Anna Lisa Ong‐Lim
… This report describes the clinical profile and outcomes of pediatric patients with acute lymphoblastic leukemia (ALL) diagnosed with tuberculosis. Methods Medical records of pediatric patients with ALL consulting at the University of the Philippines – Philippines General Hospita…
W. Richter, Keira A. Cohen
Pediatric otomastoiditis due to Mycobacterium abscessus can be a devastating infection that presents multiple treatment challenges. Van Wijk et al. report the use of a structured approach with a standardized regimen of intravenous (i.v.), topical, and oral antibiotics and surgica…
Hannah-Lena Schäfer, Michael Barker, Peter Follmann, Annette Günther, André Hörning, et al.
…longs time to effective treatment. Data on risk factors for pediatric MDR from low-incidence countries are scarce. Retrospective nationwide case–control study to analyze MDR-pTB cases in Germany between 2010 and 2020 in comparison to a drug-susceptible (DS)-pTB group. We included…
Ravi Bandhu, Sanjeev Kumar, S. Jain, Ganesh Singh, Neelam Gautam
…fampicin resistance linked to poorer outcomes. Conclusions: Pediatric DR-TB predominantly affects older children from socio-economically disadvantaged backgrounds and crowded living conditions, necessitating enhanced diagnostics, individualized treatment, and strengthened support…
Ravi Bandhu, Sanjeev Kumar, Seema Jain, Ganesh Singh, Neelam Gautam
…fampicin resistance linked to poorer outcomes. Conclusions: Pediatric DR-TB predominantly affects older children from socio-economically disadvantaged backgrounds and crowded living conditions, necessitating enhanced diagnostics, individualized treatment, and strengthened support…
Muhammad Soaib Said, Razia Fatima, O See, Amjad Khan, Mahmood Basil A. Al‐Rawi, et al.
…to multidrug-resistant (MDR) tuberculosis (TB) treatment in pediatric patients. This multicenter retrospective cross-sectional study was conducted in the programmatic management of drug-resistant tuberculosis sites in Khyber Pakhtunkhwa, Pakistan. Basic characteristics, treatment…
Munindra Pratap Singh, Pawan Kumar Sharma, Pradeep Upadhyay, Puneet Agrawal, Dinesh Gupta, et al.
…10%) turned reactive for tuberculosis by CBNAAT. None of thepediatric samples was positive for MDR TB. 66% of children completed treatment and 33% weredeclared cured. Conclusion: 42% positivity after CBNAAT testing for tuberculosis infection incollected samples of sputum and gast…
Fred Monje, Daniel Kadobera, Yakubu Owolabi, Lilian Bulage, Alex Riolexus Ario, et al.
Abstract Background: Childhood tuberculosis (TB) remains a major public health problem in Uganda. Failure to complete TB treatment is associated with development of multi-drug-resistant TB, continued spread of TB, and death. The World Health Organization (WHO) recommends treatmen…
He Huang, J Wei, Hongjie Shen, Qiang Tan, J Xue, et al.
to β-lactamase inhibitor combinations was more serious. Regular monitoring the changes of the etiology of respiratory tract infections in ICU Children is particularly important for the prevention and treatment of multidrug-resistant bacterial infections.
Princy GS, Jyoti Iravane, Maitrik Bhupendrabhai Dave
Multidrug-resistant or rifampicin-resistant tuberculosis (MDR or RR-TB) resulted in around 150,000 global deaths.The proportion of new TB cases with MDR/RR-TB declined from 4.1% in 2015 to 3.2% in 2023. 7he National Tuberculosis Elimination Program (NTEP) estimates, in India, a s…
I. B. Kulikova, I. А. Vаsilyevа, А. И. Казаков, Н. И. Клевно, С. А. Стерликов, et al.
The objective: to evaluate tuberculosis situation in the Russian Federation among children aged 0-17 years based on the analysis of key epidemiological rates from official statistics for 2023. Subjects and Methods. Information from official statistical surveillance forms was stud…
Ashish William, Yogita Rai, Ravinder Kaur
Objectives: India has the largest burden of MDR-TB worldwide, with an annual incidence of 1,30 000 patients. Multidrug-resistant tuberculosis (MDR-TB) carries a poor prognosis, a high mortality rate, and treatment success rates as low as 65%. The mortality in India is estimated t…
Zahra Hasan, Sadia Shakoor, Rumina Hasan
…ion, Geneva, Switzerland2021Google Scholar], however, 4% of pediatric cases were not notified and these occurred mainly in LMICs. Health system factors such as lack of access and marginalization account for missed cases, especially in 2020. Case notifications show a shortfall in …
Ana Alvarez, Mobeen H. Rathore
… recommendations in the areas of diagnosis and treatment of pediatric tuberculosis in the past few years. Due to the low incidence of tuberculosis in the United States, many primary care providers may not be familiar with these new recommendations.After completing this article, r…
PrasantaKumar Das, SomtirthaB Ganguly, Bodhisatya Mandal
…of an effective control. India accounts for 6% incidence of pediatric TB cases in a population that has 40% as estimated latent TB cases. Pediatric samples were considered as the key population in the study. TB remains the most common cause of childhood meningitis in high burden …
Yiheyis Genetu, Bethelhem Belay, Workeabeba Abebe
… DNA and resistance to rifampicin (MTB/RIF) test can detect pediatric tuberculosis and its multidrug-resistant form with very high sensitivity and specificity, but limited data exists on its use in our country. We aimed to evaluate the effectiveness of the GeneXpert assay in comp…
Arnab Kumar Samanta, K. Pál, Priyanka Saha, Retina Paul
Background: Febrile illness in pediatric populations often poses a diagnostic challenge due to overlapping clinical features across various etiologies. While respiratory infections are common, urinary tract infections (UTIs) are significant contributors to morbidity, frequently c…
International Centre for Diarrhoeal Disease Research, Bangladesh
…ms to fill critical knowledge gaps, particularly concerning pediatric post-TB health outcomes, by evaluating a cohort of individuals who have completed TB treatment and comparing them with non-TB-exposed counterparts. The study will also assess quality of life, growth in children…