Showing 1–25 of 29 documents
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Jennifer Cohn, MD, Martina Casenghi, PhD
…ll be conducted in ten countries involved in the Catalyzing Pediatric TB Innovation (CaP-TB) project: Cameroon, Cote D'Ivoire, Democratic Republic of Congo, Kenya, Lesotho, Malawi, Tanzania, Uganda, Zimbabwe and India. The CaP-TB project is a project designed to use innovative me…
Heiman F Wertheim, PhD
…ypically have low yield due to the paucibacillary nature of pediatric TB. Culture confirmation may be obtained in as few as 10% of cases of suspected pediatric TB. For these reasons, the true extent of the (drug-resistant) TB epidemic in children is unknown. Thus, either clinicia…
Silvia S. Chiang, Helen E. Jenkins
… 5-year age bands for people <25 years old.In this issue of Pediatrics, Osman et al13 address these research gaps by analyzing the South African Electronic Treatment Register, a national surveillance database of individuals treated for drug-susceptible TB. The study includes ∼85 …
Harsh Shah, Sandul Yasobant, Jay Patel, Priya Bhavsar, Deepak Saxena, et al.
…uch as drug-sensitive TB (DSTB), drug resistance TB (DRTB), pediatric TB, and extra-pulmonary TB. It included both public and private sector patients. The study's findings suggested that 172 (29%) patients experienced ADRs with at least one symptom. Out of those, 80% had mild sym…
Anna Turkova, Genevieve H. Wills, Eric Wobudeya, Chishala Chabala, Megan Palmer, et al.
…eks) of standard first-line antituberculosis treatment with pediatric fixed-dose combinations as recommended by the World Health Organization. The primary efficacy outcome was unfavorable status (composite of treatment failure [extension, change, or restart of treatment or tuberc…
University of Virginia
…re conversion and weight change are stratified by age given pediatric populations are more likely to be culture negative and clinically diagnosed with weight gain a central measurement of treatment response. Safety of dose adjustment strategy parameters include clinical adverse e…
Anbesan Hoole, Ahsan Ilyas, Sunaina Munawar, Matthew Cant, Rizwan Hameed, et al.
Abstract Introduction While Post Tuberculous (TB) Bronchiectasis is the most common cause of Bronchiectasis in South Asia, there has been little research into its microbiology and clinical characteristics in Pakistan. This single centre retrospective cohort study at Bach Christia…
Malika Gabdullina, Saya Gazezova, Gulzhan Ayapova, Manar Smagul, Roberta Horth, et al.
Abstract Background The COVID-19 pandemic negatively influenced the availability of TB related services around the world, including detection, diagnosis and treatment. The purpose of this research is to assess the impact of the COVID-19 pandemic on TB treatment outcomes in Almaty…
M.J. Cavaco, Sofia Giusti Alves, L. Mateus, André Nunes, Ricardo Cordeiro, et al.
<b>Introduction:</b> Tuberculosis (TB) remains a major health problem, with extensive research on case detection and treatment outcome. However, little is known about what happens after treatment completion. In the First International Symposium on post-TB lung health (2020), the …
Muhammad Abdul Hadi
Background: The optimal doses of first-line drugs for treating drug-susceptible tuberculosis in children and adolescents are still uncertain.
 Aim: The purpose of this study was to determine whether children treated with recommended or increased doses of first-line drugs ach…
Nduagu Samuel Uchechukwu, ONYEAGWARA Ngozi Carol, Ogisi Festus Oritsemajemite, MBATA Godwin Chukwuemeka
Background: Pulmonary tuberculosis is a debilitating infectious disease that affects all age groups and sadly, a leading cause of death in developing countries particularly in sub-Saharan Africa. One major challenge facing the global efforts against tuberculosis is drug-resistanc…
O. Omosebi, Olanrewaju S.O., Adejumo O.A.
TB is perhaps the most important contagious disease in the world and the leading cause of mortality by an infectious disease. As a result, WHO declared that achieving the reduction in TB incidence rate for achievement of the 90-90-90 target of the END-TB strategy will be an illus…
Sang Chul Lee, Jae Kwang Lee, Jung Mo Lee, Seon Cheol Park, Chang Hoon Han
Abstract Background Political change regarding for exemption of co-payment for tuberculosis (TB) treatment was made in July 2016. We investigated the effect of the co-payment waiver on long-term treatment interruption and clinical outcomes among pulmonary TB patients in South Kor…
Flávia M. Sant ́Anna, Mariana Araújo‐Pereira, Carolina Arana Stanis Schmaltz, María B. Arriaga, Raquel de Vasconcellos Carvalhães de Oliveira, et al.
Standard anti-tuberculosis treatment is highly effective, but a great challenge is the management of adverse drug reactions (ADR). Our study aimed to characterize ADR according to type, severity and time of occurrence. A prospective tuberculosis (TB) cohort has been followed, fro…
Nadia Jawad, Nausheen Saifullah, Naseem Ahmed, Saira Jafri
Abstract Aim: To determine the factors associated with persistent sputum positivity at the end of two months of treatment in patients presenting with (drug-susceptible) pulmonary tuberculosis at a tertiary care hospital in Karachi.Setting: A cross-sectional study was conducted at…
Nhat Linh Nguyen, Fuad Mirzayev, Kerri Viney, Medea Gegia, Matteo Zignol
<b>Background:</b> Recent developments in TB treatment have prompted the need for revision of the TB treatment outcome definitions. <b>Aims and objectives:</b> The objectives of the WHO consultation were to determine recent changes in TB treatment affecting treatment outcome defi…
Amit Barua, Joseph Hubble, Kathryn H. Yoo, Michael Lacassagne, John P. Areno, et al.
Recurrence of Pulmonary tuberculosis (TB) after successful completion of supervised treatment may be due to relapse or reinfection. Recurrence is common with an incidence rate of 2.26 per 100 person years over a mean follow up of 2.3 years. However, it is uncommon for an immunoco…
Christopher A. Berger, R. Crowder, A. Kityamuwesi, Noah Kiwanuka, M. Lamunu, et al.
Background: Tuberculosis (TB) treatment completion rates are below global targets. 99DOTS is a low-cost digital adherence technology (DAT) that could increase TB treatment completion. Methods: We conducted a pragmatic, stepped-wedge cluster randomized trial including all adults t…
Nelly Solomonia, K Vacharadze
Georgia has countrywide access to the genotypic and phenotypic drug susceptibility testing (gDST and pDST), however identification of susceptibility to the different anti-Tuberculosis (TB) drugs in different time period, not in all cases gives us opportunity to simultaneously kno…
Nicole Robertson, J. Zachary Porterfield, Alex Kayongo, Bruce Kirenga, Robert Kalyesubula, et al.
Abstract Background Pulmonary tuberculosis (TB) is the leading infectious cause of death globally with an estimated 1.7 billion people currently infected with Mycobacterium tuberculosis and at risk of developing TB. While the treatment of drug-susceptible pulmonary TB is highly e…
M.G. Mustapha, Garba Mohammed Ashir, AI Rabasa, Asmaa Farouk, Hassan Abdullahi Elechi, et al.
Tuberculosis (TB) is an important infectious disease of public health concern. The effects of TB on children in terms of morbidity and mortality is more than that of adults. These may not be unconnected with the differences in characteristics and peculiarities of the disease in c…
Rida Masood, Naeem Muhammad Iyad, Kanwal Ali Sidra, Mushtaque Madiha, Siddiqui Tuba, et al.
This assessment aims to identify the increasing number of morbidity of drug susceptible tuberculosis (TB) and its treatment outcomes, government cost of medicines as well as the economic impact on society. A retrospective observational study had been conducted in a government hos…
Cielo Ríos, Marcela Vásquez Rojas, Martha Lucía Serrano, Alexandra Porras, Ricardo Luque, et al.
We investigated the delays in the diagnosis of tuberculosis and/or HIV, their treatment initiation, and factors associated with each delay. All drug-susceptible tuberculosis cases diagnosed in 2014 and 2015 in Colombia, with a confirmed diagnosis of HIV were included. A total of …
Shaki Aktar
The prevalence of tuberculosis (TB) is reducing in Bangladesh, but the emergence of drug resistant tuberculosis make the TB control effort more challenging and questionable. The present study aimed to identify the socio-demographic, behavioral and clinical risk factors for develo…
M R Marll, M Magee, N Glover, T Ngwanto, N Mofokeng, et al.
Abstract Rationale Approximately half of all tuberculosis (TB) survivors develop post-TB lung disease (PTLD), defined as persistent respiratory abnormalities despite a microbiological cure. Fibrosis, which typically presents as a restrictive ventilatory impairment on pulmonary fu…