Showing 1–25 of 200 documents
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Itu Singh, Utpal Sengupta
… continued till the appearance of primary and secondary DDS resistance during the 1970s.[45] Most of these DDS-resistant cases originated from fully treated relapse cases. However, it was noted that low doses of dapsone and irregular treatment were the major causes of relapse.[5]…
М.В. Ураксина, Petr Rogozhkin, Ekaterina Eremenko
…ic indicators for tuberculosis, the number of patients with drug-resistant forms of tuberculosis is increasing, which complicates and prolongs the treatment of such patients. The aim of the work is to study the drug resistance of Mycobacterium tuberculosis obtained from surgical …
Guo Liang Gan, Matthew H. Nguyen, Elijah Willie, Mohammad H. Rezaie, Brian Lee, et al.
Abstract The efficacy of antibiotic drug treatments in tuberculosis (TB) is significantly threatened by the development of drug resistance. There is a need for a robust diagnostic system that can accurately predict drug resistance in patients. In recent years, researchers have be…
Derner, Catherine Marie
…t challenges to effective treatment due to the emergence of drug-resistant strains. The prevalence and mechanisms of drug resistance amplification in TB remain areas of ongoing research and debate. This study investigated the consequences of suboptimal treatment on the acquisitio…
Lei Wang, Zhidong Teng, Ramziya Rifhat, Kai Wang
Tuberculosis has been prevalent in Xinjiang with severe drug resistance situation. It is unclear that which Mycobacterium tuberculosis (M.tb) infections (drug sensitive or drug resistant) most affected the tuberculosis incidence, how to identify the relative contribution of prima…
Tarun Narang, Divya Kamat, Vishal Thakur, Mallika Lavania, Itu Singh, et al.
…dia. It is believed that bacilli persisting even after multidrug therapy can cause relapse; recently, however, drug resistance as a cause for recurrences and chronic erythema nodosum leprosum (ENL) has been speculated. AIM: To study drug-resistance patterns in cases of leprosy re…
Cuiyu Liu, Suping Li, Pan Baoshan, Hui Xing, Liang Bohui, et al.
Objective To understand the prevalence of drug resistance in pulmonary tuberculosis (TB) patients in Jiamusi, Heilongjiang province, and provide reliable references for the prevention and control of TB. Methods Mycobacterium tuberculosis strains isolated from 575 TB cases collect…
Dennis Mujuni, Willy Ssengooba, Ivan Ibanda, Joel Kabugo, Dianah Linda Kasemire, et al.
…nt success rates stemming from the emergence of second-line drug resistance. We aimed at determining the usefulness of second-line drug (SLD) resistance markers as proxy indicators of time to sputum culture conversion; a renowned predictor of Tuberculosis treatment outcome, among…
Naila Samad, Ghulam Mustafa Wardak, Fakhra Batool, Hadeel Ahmed Kenoosh, Nnamdi C. Opara, et al.
Background. Pakistan is high burden drug resistant tuberculosis (DR-TB) country. For devising a treatment regimen and optimizing empirical drug therapy, the local epidemiology and drug resistance patterns are needed to be considered. Objectives. To evaluate the drug resistance pa…
Aarav Sinha, Jothsna Kethar, Dr.Rajagopal Appavu
Drug-resistant tuberculosis (TB) poses a significant global health challenge, affecting millions worldwide. Annually, around half a million individuals develop drug-resistant TB, underscoring the urgency of addressing this issue. Treating drug-resistant TB is complex and lengthy,…
V Bajiya, C R Choudhary, G Purohit, A Kuwal, A Mohanty
<b>Background:</b> Drug resistant tuberculosis is a serious public health problem in India. Due to inappropriate use, resistance to FQs has increased, which is a major threat to control TB worldwide. FQ resistance is caused by mutation in gyrA and gyrB genes of Mycobacterium tube…
Ifrah Amjad, Saba Riaz
…rganisms. Microorganisms have noteworthy amplitude to offer resistance to antimicrobial agents and becoming an awful public health plight. The rising probability of infections is attributed to the ability of microbes conferring drug resistance. Drug resistance is a horrible capac…
Deepika Rai, Priyanka Padwal, Priyanka Purkayastha, Sarika Mehra
ABSTRACT Resistance to multiple drugs is one of the significant barriers in the treatment of tuberculosis (TB). Knowledge of mechanisms of resistance is important to design effective treatment strategies. While mutations in genes coding for drug targets are thought to be the prim…
Paulina M. Mejía‐Ponce, Elsy Janeth Ramos-González, Axel Alejandro Ramos-García, Edgar E. Lara‐Ramírez, Alma R. Soriano-Herrera, et al.
…es worldwide. New diagnostic tools and approaches to detect drug-resistance must be introduced by 2025 to achieve the End-TB Strategy goals set for 2030 by the WHO. Genomic epidemiology of TB has allowed the expansion of catalogs listing genetic signatures of Mtb drug-resistance.…
Álvaro Auñón, Santiago Gabardo, Carmen Álvaro, Ricardo de la Concha, Javier Sanado, et al.
…thetic joint infection (PJI), but the outcome impact of key resistance phenotypes is unclear. Methods: We retrospectively studied consecutive monomicrobial S. epidermidis PJIs treated at a tertiary hospital (2010–2024). PJI was defined according to 2018 ICM criteria. Success requ…
Rashmi Jindal, Itu Singh, Sadhana Bhardwaj, Payal Chauhan
…n. However, an additional problem emerging is antimicrobial resistance (AMR) to anti-leprosy drugs, especially rifampicin that forms the backbone of WHO multi-drug therapy. WHO recommends testing for AMR in all relapse cases and a sample of new multibacillary (MB) cases.[2] Howev…
Ketema Tafess, Timothy Ting-Leung Ng, Hiu Yin Lao, Kenneth Siu Sing Leung, Kingsley King Gee Tam, et al.
…mergence of Mycobacterium tuberculosis strains with complex drug resistance profiles necessitates a rapid and extensive drug susceptibility test for comprehensive guidance of patient treatment. Here, we developed two targeted-sequencing workflows based on Illumina MiSeq and Nanop…
Prerna Jasmine Kerketta
…s (TB) by 2025.So we need to have high adherence to anti-TB drugs. We conducted this study to know the adherence to second line drugs for drug-resistant TB. It was a prospective-observational study conducted from November 2022 to May 2024. After obtaining informed consent from th…
Thi-Kim-Thang Dao, Dao Dinh, Mai-Hien Chuc, Hai‐Anh Ha
…m 448 inpatient TB cases throughout 2022, encompassing both drug-sensitive and drug-resistant forms of TB. Analysis revealed that drug-resistant TB patients incur significantly higher treatment costs compared to those with drug-sensitive TB, with costs escalating further among ol…
Tong Chen, Tianchi Yang, Xiang Lin, Sijia Wang, Ping Guo-hua, et al.
ObjectiveTo evaluate the levels and patterns of drug resistance in initially treated smear-negative pulmonary tuberculosis (TB) patients in Ningbo, and provide scientific evidence for the prevention and control of drug-resistant TB. MethodsSputum samples of 1 434 initially treate…
Zhongchen Ma, Tianhao Sun, Xinyu Bai, Xiang Ji, Qian Zhang, et al.
Introduction In recent years, drug-resistant Mycobacterium tuberculosis strains have gradually become widespread. Most drug resistance is related to specific mutations. We investigated M. tuberculosis drug resistance in the Kashgar area, China. Methods The drug-susceptibility tes…
Elmiawati Latifah, Endang Yuniarti, Rinto Susilo, Hidayah Karuniawati, Nur Azizah, et al.
Drug-resistant tuberculosis (TB) is a public health problem that poses major challenges to patients, health workers, society, and the health care system. This research is a qualitative study to explore the implementation of drug side-effect monitoring and the role of health worke…
Yi-Ran Han, Tianhao Wang, Wenping Gong, Jianqin Liang, Huiru An
…nical efficacy of thymopentin combined with antituberculous drugs in treating drug-resistant pulmonary TB (PTB).Methods: Relevant studies were retrieved from PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database, CNKI, and Wanfang Database. STATA software was u…
Tamilarasu Kadhiravan
Drug-resistant tuberculosis is an important public health problem. 1 Erratic adherence to antituberculosis treatment often results in treatment failure and is widely considered to be the driving force behind the emergence of drug-resistance in previously treated patients."Drugs d…
Н. А. Мацегора, S.O. Polyakova
…logical and biochemical disorders in patients with isolated drugs resistant tuberculosis (DRTB) and coinfection of DRTB/HIV/AIDS in the terminal phase, to assess the extent of their linear relationship.Materials and methods. The method of continuous sampling analyzed the histori…