Showing 1–25 of 200 documents
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Hanif Esmail, Gopalan Narendran, Andrew Nunn
The management of drug-resistant tuberculosis (DR-TB) has been a formidable challenge for patients, healthcare providers and public health systems for many years. In particular, for multidrug-resistant TB (MDR-TB), resistant to both rifampicin and isoniazid, the available treatme…
Cicilia Windiyaningsih, Hendra Badaruddin
…sistant tuberculosis is a global challenge especially multi-drug resistant TB (MDR-TB). Drug-resistant Tuberculosis is classified as a condition where Mycobacterium tuberculosis can’t be treated with anti-tuberculosis drugs. The study aimed to determine the associated risk factor…
Neetha S. Murthy, Sanjeev Nair, P. Ramya, Renu Susan George, B Ravikrishnan, et al.
Resistance to antimycobacterial agents consistently remains a major obstacle to end TB in India. Geographical prevalence data regarding drug-resistant evolutionary genetics of M. tuberculosis (MTB) remains sparse in India. Our objective was to determine the genotypic drug resista…
Microbiologist- External Quality Assurance, State TB control Society, Port Blair, Andaman and Nicobar Islands, Keerthivasan Gurumurthy
… concern in India especially with the increasing numbers of drug-resistant cases of tuberculosis. Lack of early diagnosis, inadequate and inappropriate treatment are the major contributors to the development of drug resistance. PMDT strategy strives for early diagnosis and approp…
Wencong He, Yun‐Hong Tan, Peiying Li, Jingjing Bao, Yimeng Song, et al.
ObjectiveTo analyze the dynamic trend of drug resistance of Mycobacterium tuberculosis in Leiyang city, Hunan province from 2013 to 2017, and to understand the local drug resistance spectrum of M. tuberculosis, so as to provide evidences for the formulation of chemotherapy regime…
P Sudha Kumari, M Siva Durga Prasad Nayak, Usha Devi, Susmita Susmita, SG Sushma
…f the World Health Organisation (WHO) on the disease. Multi-Drug Resistant TB (MDR-TB) cases have been increasing in India. About half of the world’s MDR-TB cases are present in India. Aim: To assess the incidence of drug resistant TB in Prakasam district, Andhra Pradesh, India, …
Xiujuan Zhao, Lin Liu, Xingyong Wu, Sijing Li, Biao Liu, et al.
Abstract BackgroundThe emergence of antimicrobial resistance against mycobacterium tuberculosis has become the major concern in global tuberculosis control due to its limited therapy options and high mortality. However, the clinical and molecular characteristics of drug-resistant…
Hongkuan Yang, Yahong Cheng, Haoli Ma, Y. Li, Bei Han
Objective: To understand the epidemic status of drug-resistant Mycobacteriun tuberculosis in Xi'an in the past three years, and the impact of COVID-19 epidemic during 2020 so as to provide basic information for local multidrug-resistant tuberculosis (MDR-TB) prevention and treatm…
Mevlüt Karataş, Tülin Kuyucu, Tülin Sevim
…btained from TB surveillance forms, bacteriology laboratory drug resistance database and octomed patient follow-up program. Results: N=1146 (65.4%) of the cases were male and n=607 (34.6%) were female. The male/female ratio was 1.8 and the highest cases were observed in the 15-24…
Nesri Padayatchi, MBChB, PhD
…omparing treatment success of a gene-derived individualized drug-resistant Tuberculosis regimen to a standard Tuberculosis regimen based on South African National Tuberculosis guidelines. When drug resistance is detected by molecular methods such as the Xpert MTB/RIF assay, seco…
Anila Jaleel, Farouk Qamar Malik, Imran Ali Zaidi, Sana Hafeez, Kiran Namoos
…se which is approximately 270 per 100,000. The emergence of drug resistant MTB poses a serious threat to the ongoing efforts to control the disease epidemic. Drug resistance to the first line drugs such as Isoniazid (INH) and Rifampicin (RIF) needs to be investigated. In this res…
Fizza Mushtaq, Syed Mohsin Raza, Adeel Ahmad, Hina Aslam, Sunia Karam Din, et al.
…nvolves the administration of a panel of five antimicrobial drugs for the period of 6 months. The purpose of this study was to determine antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure and to determine efficacy of the second l…
Abbas Abel Anzaku
Abstract Background: This study evaluated the prevalence of drug resistant tuberculosis infection among suspected tuberculosis patients attending Asokoro District Hospital (ADH), Abuja, Nigeria. Methods: A total of 301 AFB+/- sputum specimens from suspected TB patients were colle…
Robin Varughese John, Hafiz Deshmukh, Sunil Jadhav, Ashish Deshmukh, Shivprasad Kasat, et al.
OBJECTIVE: To study the sensitivity and resistance pattern of multi-drug resistant tuberculosis patients at a tertiary care centre. METHODS: Retrospective study will be conducted at tertiary care centre in Aurangabad from which data of patients will be collected who have register…
Jalil Kardan-Yamchi, Hossein Kazemian, Arash Ghodousi, Daniela María Cirillo, Masoumeh Douraghi, et al.
Aims and objectives: Treatment of patients with drug-resistant tuberculosis is time-consuming and requires expensive drugs with more toxicity. Proper and timely identification of drug-resistant genotypes and determining the minimum inhibitory concentrations (MICs) alongside with …
Tawsifur Rahman, Amith Khandakar, Ashiqur Rahman, Susu M. Zughaier, Muna Al Maslamani, et al.
… and expensive treatments. Moreover, due to the increase of drug-resistant tuberculosis, the disease becomes more challenging in recent years. In this work, a novel deep learning-based framework is proposed to reliably and automatically distinguish TB, non-TB (other lung infectio…
Manita Yimcharoen, Sukanya Saikaew, Usanee Wattananandkul, Ponrut Phunpae, Sorasak Intorasoot, et al.
…mains a global health concern because of the development of drug resistance. The adaptability of MTB in response to a variety of environmental stresses is a crucial strategy that supports their survival and evades host defense mechanisms. Stress regulates gene expression, particu…
Callistus A. Akinleye, Adekola O. Adekunle, A. Onabule, Olugbenga Adekunle Olowe, Olusoji Daniel
… tuberculosis has left everlasting scars on people’s lives. Drug-resistant tuberculosis is becoming an increasingly serious hazard to public health. With over 240,000 fatalities due to drug-resistant tuberculosis (DR-TB) worldwide, and Nigeria is one of the 14 nations with a sign…
Noorsuzana Mohd Shariff, Shamsul Azhar Shah, Fadzilah Kamaludin
…ients had a significant contribution to the transmission of drug-resistant tuberculosis in the community. However, little is known about the profile of foreign-born drug-resistant patients in Malaysia, and this has become the aims of this current study. Methods and materials: Thi…
Balaji Zacharia, Antony Roy
…the increased prevalence of HIV infection. The incidence of drug resistance strains of mycobacterium is also on the rise. When the mycobacterium is resistant to both INH and rifampicin it is called multi drug resistant tuberculosis. There is a primary and an acquired type of drug…
Dirie AMH, S Çolakoğlu, Abdulle OM, Abdi BM, Osman MA, et al.
…ospital, Mogadishu, Banadir, Somalia; 2Manager of the Multi-Drug Resistant Center in Southern Somalia, Mogadishu, Banadir, Somalia; 3HIV Program manager, Ministry of Health, Somali Federal Government, Mogadishu, Banadir, Somalia; 4Infectious and Microbiology Department, Somalia M…
Oyeniyi Muhammed, Israel Olukayode Popoola, Muhammed Mubashir B Uthman, Ebenezer Obi Daniel, Taiwo Popoola, et al.
… in regions like Nigeria. In this context, the emergence of drug-resistant strains of Mycobacterium tuberculosis poses an escalating challenge. This study aimed to assess awareness of anti-TB drug resistance among TB patients in Kwara State, Nigeria. Utilizing a descriptive cross…
Amyn A. Malik, Mercedes C. Becerra, Hamidah Hussain
…y of TB preventive treatment for persons exposed at home to drug-resistant tuberculosis (DR-TB) [[3]Brooks M N.E. Hussain H. Malik A. Jaswal M. Siddiqui S. Barry Z. Fuad J. Becerra M.C. Seddon J. Furin J. How to care for people exposed to drug-resistant tuberculosis: a practical …
В. Н. Даниленко
…ssue of the growing morbidity and mortality caused by multi-drug-resistant (extreme drug-resistant) tuberculosis (TB). This issue is aggravated by the alarming rise of immunocompromized patients and immigration worldwide. In order to solve this problem, an interdisciplinary appro…
Tingting Li
…, significantly compounded by the rising prevalence of multidrug-resistant (MDR-TB) and rifampicin-resistant (RR-TB) strains [1,2]. The cornerstone of effective TB management is timely and accurate diagnosis, yet the current gold standards for detecting drug resistance-molecular …