Showing 1–25 of 170 documents
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Imtiaz Pasha, Ashraf ALakkad
Background: Drug-resistant tuberculosis (DR-TB) poses significant challenges to public health, with poor outcomes frequently observed in affected patients. This study aims to evaluate the characteristics and factors associated with poor outcomes in patients with drug-resistant pu…
S. Lakshmi Kumari, Srikanti Raghu, Karri Maruthi Devi, AswinaTripura Sundari, D Sudheer, et al.
…H) is one of the most important first-line antituberculosis drugs used for the treatment of active tuberculosis (TB) and latent TB infection (LTBI) with high bactericidal activity and a good safety profile. The emergence of TB strains resistant to isoniazid threatens to reduce th…
Elisa H Ignatious, Susan Swindells
…easingly available across the spectrum of TB, including for drug-resistant TB. Simultaneous treatment of HIV and TB is complicated by drug-drug interactions, although trials are ongoing to better understand the magnitude of these interactions and guide clinicians in how to use sh…
Alimuddin Zumla, Jeremiah Chakaya, Mishal Khan, Razia Fatima, Christian Wejse, et al.
…cluding provision of more rapid and complete information on drug-resistance, detection of transmission clusters, contamination events, mixed infections, and to differentiate between re-infection and relapse. They also discuss future advances that have the potential to change the …
E Kırımi, Jeconiah A. Okelo, Mark Kimathi, Kenneth Ngure
…s and pneumonia co-infection is formulated, incorporating a drug-resistant strain. The model employs a Holling-type functional response to capture the impact of natural immunity on the progression from latent tuberculosis infection to active disease, as well as its role in contro…
World Health Organization. Regional Office for the Eastern Mediterranean
Zelalem Temesgen, Daniela María Cirillo, Mario Raviǵlione
…nd facilitation of rapid expansion at the population level. Drug-resistance is an emerging crisis for which appropriate diagnostic tools are either unavailable or inadequate. Conventional phenotypic drug-susceptibility testing can identify only low numbers of resistance mutations…
Jerome Manzano, Lerma Bhelle B Iglesia, Vikki Darl R Rodriguez, Julius Patrick R Miranda, Regina Berba
…Isoniazid is used in short course second line treatment for drug resistant tuberculosis. It is not only needed for the treatment of active tuberculosis but also highly effective in preventing disease and for latent TB infection. However, isoniazid resistance is regarded to underm…
Li TL, Chan TH, Chenghui Wang, Jou R, Yu Mc, et al.
… cough and was found to harbor active TB disease with added resistance to isoniazid. An individualized anti-TB regimen consisting of moxifloxacin, kanamycin, prothionamide, ethambutol, and pyrazinamide was prescribed for 20 months, leading to sputum culture conversion and improve…
Archivel Farma S.L.
… of recovery of patients without inducing the appearance of drug resistance. The safety and immunogenicity of RUTI was established in healthy volunteers, patients with latent tuberculosis (TB); and Drug Susceptible (DS) -TB and Drug resistance (DR)-TB. This study proposed to eva…
Xin Zhang, Ruixia Zhao, Yao Qi, Xiong Yan, Gaoxiu Qi, et al.
…regimen has a long treatment cycle and is prone to multiple drug resistance. Anti-tuberculosis drugs and latent tuberculosis infection (LTBI) resistance are increasing year by year, and new targets and new bioactive compounds are urgently needed to treat this disease. This review…
Samuelk Paul
…ad use of molecular technology and the rapid assessment for drug resistance using nucleic acid amplification testing has greatly enhanced the diagnosis of smear-positive and smear-negative TB. To this end, the International Standards for Tuberculosis Care have been updated and of…
Anjana Dogra, Sheetal Agarwal
…ficulty in specimen collection and increasing prevalence of drug-resistant TB. Recent advances in diagnostics, therapeutics and preventive strategies have transformed the management of TB in children. Methods: This narrative review summarises recent evidence, World Health Organis…
Ketan N Malu, Avinash Lamb
…b>Background:</b> Isoniazid(INH) is an important first line drug in the management of active and latent TB. It’s widespread use and lack of diagnostic testing has resulted in increase in prevalence of Hr-TB, either alone or in combination with other drugs. katG and inhA mutations…
…-tion, the growth of severe forms of the disease, caused by drug-resis tant strains of mycobacterium tuberculosis, continues. The drug resistance of the pathogen, which WHO has de signated as a global threat, the crisis of clas-sical antibio tic therapy dictate the need to develo…
N. Rao, Ruchi Bhosale
…ch year despite medical breakthroughs. Long-term therapies, drug-resistant TB strains, and co-infections with conditions like HIV necessitate novel approaches. The use of Mycobacterium tuberculosis (Mtb) efflux pumps, which actively expel drugs and decrease their effectiveness, i…
KN Malu, AR Lamb
…>Background</h3> Isoniazid (INH) is an important first line drug in the management of active and latent TB. Its widespread use and lack of diagnostic testing has resulted in an increase in the prevalence of Hr-TB, either alone or in combination with other drugs. katG and inhA mut…
…ocated a dormant "hi-bernation" with a lack of replication. Drug tolerance, phenotypic resistance, which differs from genetically determined drug resistance in that persistent mycobac-teria with sharply reduced metabolism simply do not respond to antibacterial drugs. L-transforma…
Delia Goletti, Seif Al-Abri, Giovanni Battista Migliori, Cecilia S. Lindestam Arlehamn, Pranabashis Haldar, et al.
… deaths yearly, mostly in low- and middle-income countries. Drug-resistant TB is the leading cause of death owing to antimicrobial resistant disease in the world today and is a growing global health security threat, with hundreds of thousands of people affected every year [1World…
Adrian Martineau, PhD
…%. Preventive therapy (e.g. a 6-month course of the anti-TB drug isoniazid) is effective in reducing risk of progression from LTBI to active TB. Global roll-out of preventive therapy will be required to achieve the World Health Organization target of TB elimination by 2050, but t…
Helen Ayles, Professor
…HCF) and were treated with standard 6-month TB regimens for drug-susceptible TB and referred for treatment according to national guidelines if they had drug-resistant disease. All TB treatment was provided by government HCF. All HIV positive individuals who presented to the clini…
Ayesha J Verrall, Philip C. Hill, Dougal Thorburn, Michael J. Maze, Lavinia Perumal, et al.
…propriate treatment; 5) optimise the prevention and care of drug-resistant TB; 6) ensure continued surveillance, programme monitoring and evaluation and case-based data management; 7) invest in research and new tools; and 8) support global TB prevention, care and control. In New …
Mohd Fazeli bin Sazali, MD, MPH
…nt outcome, such as the increased risk of relapse, acquired drug resistant TB, treatment failure, progression of disease leading to complication, risk of death, and ongoing transmission of disease in the community. Adherence to TB therapy is critical for the success of TB treatm…
Mohammed Abdalla Rakha, Asmaa Ali, Mohmod Omer, Ahmed Alsyed, Eman Al- Anbay
…5. Moreover, we found a considerable double number of multi-drug resistance pulmonary tuberculosis and one case suspected extensive drug resistance. Conclusion: Covid 19 pandemic had a significant impact on tuberculosis care as regards diagnosis and treatment as well as follow-up…
Charisse Mandimika, Gerald Friedland
…allenges in the prevention and treatment of TB/HIV disease. Drug-susceptible and drug-resistant tuberculosis (TB) and human immunodeficiency virus (HIV) epidemics are a consequence of reactivation of latent TB infection (LTBI), treatment-related amplification of TB resistance mut…