Showing 1–25 of 200 documents
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Prabha Desikan, Aseem Rangnekar, Nikita Panwalkar, Ram Prakash Punde, Sridhar Anand
Detection and treatment of drug resistance in extrapulmonary tuberculosis (EPTB) is a major challenge worldwide. Drug resistance in EPTB has not been studied extensively. However, patients with drug-resistant EPTB have been reported to have poor outcomes[1]. Rifampicin and isonia…
Bahram Nasr Esfahani, Sharareh Moghim, Mahshid Salehi, ShimaSadat Farzaneh, Marzieh Safari
…he genetic diversity and phylogenetic relationships of both drug-susceptible and drug-resistant Mycobacterium tuberculosis complex (MTBC) isolates with respect to first- and second-line anti-tuberculosis drugs using the 24-locus Mycobacterial interspersed repetitive units-variabl…
Varalakshmi Vummidi, Sekhar Talluri
…ulosis (TB) is a significant global health challenge due to drug resistance. Furthermore, tuberculous meningitis (TBM), which affects the central nervous system, has a particularly high mortality rate. TBM drugs have low efficacy because of their low blood-brain barrier (BBB) per…
N Kusuma
…lth challenge, especially in immunocompromised individuals. Drug-resistant TB poses additional therapeutic obstacles, necessitating detailed case documentation and tailored treatment approaches. This case report presents a primary infection of drug-resistant laryngitis TB in an i…
K Mukanbaev, A. A. Turkmenov, A. A. Toktogonova, M. D. Kozhomkulov, Джун Чой Ен
…ction of molecular genetic and phenotypic rapid methods for drug susceptibility testing. Subjects and Methods. From 2018 to 2021, epidemiological surveillance forms for drug-resistant tuberculosis (DR TB) (TB 06, Table 3b for Results of Drug Susceptibility Testing to First- and S…
Andrey Zyubin, Anastasia I. Lavrova, Eugenie Postnicov, Marine Dogonadze, Elizaveta Demishkevich, et al.
The Mycobacterium tuberculosis (MbT) drug resistance remains a serious problem for global public health and usually leads to a lethal outcome. Precise and rapid identification of a specific MbT strain is vital for the appointment of antituberculosis therapy. We continue investiga…
Sanchit Mohan, Nupoor Vaghasia, Vishwanath Pujari, Priti Meshram
…f secondary ITP. Linezolid, despite being the backbone of a drug-resistant TB regimen, is the most common drug to cause thrombocytopenia in this subset of patients. Treatment of ITP requires immunosuppression with pulse steroids and intravenous immunoglobulin which can lead to di…
Doctor Busizwe Sibandze, Beki Themba Magazi, Lesibana Anthony Malinga, Nontuthuko Excellent Maningi, Bong Akee Shey, et al.
…is (EPTB). We investigated Mycobacterium tuberculosis (Mtb) drug resistance and transmission patterns in EPTB patients treated in the Tshwane metropolitan, South Africa. Methods Consecutive Mtb culture-positive non-pulmonary samples from unique EPTB patients underwent further myc…
Zina M.A. Alshami, Ahmed Mohammed Ali Alshammari, Ali N. Al-Awwady
…diseases that causes a significant rate of death worldwide. Drug-resistant Mycobacterium tuberculosis has been categorised into different categories according to its resistance type. Emergence of new noncategorized strains in the post-COVID-19 years among non-HIV-infected patient…
Jing Tong, Mengqiu Gao, Yu Chen, Jie Wang
…tion, low specimen content, and the increasing incidence of drug-resistant tuberculosis, which makes the accurate diagnosis and timely treatment of childhood tuberculosis face monumental challenges. Case presentation: The 14-year-old female, was admitted to the hospital with inte…
Anastasia I. Lavrova, Andrey Zyubin, Marine Dogonadze, Evgenii Borisov, Ilia Samusev, et al.
…argue that the SERS technique allows distinguishing between drug-sensitive and drug-resistant strains on the level of resolution of individual mycobacteria. This result is based on the experimental investigations of deactivated M. tuberculosis strains by the Raman spectroscopy in…
Mahmoud M. Tawfick, Mona Shaban E. M. Badawy, Mohammed Taleb, Nagwan G. El Menofy
…cation strategy is hampered by the global health concern of drug-resistant (DR) TB. Effective patient treatment, preventing TB transfer and avoiding the upsurge of DR strains depend primarily on the timely and accurate identification of DR TB. Due to inadequate sensitivity, the n…
Herikurniawan Herikurniawan, Joanna Audrey, Mira Yulianti, N Indira, Cleopas Martin Rumende
…lungs but also the extrapulmonary organs. The prevalence of drug-resistant tuberculosis (DR-TB) is rising and has caused a higher mortality rate than drug-susceptible tuberculosis (DS-TB). This article presents a patient with a rare co-infection of pulmonary DS-TB and pleural DR-…
Radha Gopalaswamy, Azger Dusthackeer, Silambuchelvi Kannayan, Selvakumar Subbian
…cies. While EPTB due to MTBC responds to first-line anti-TB drugs (ATD), drug susceptibility profiling is an essential criterion for addressing drug-resistant EPTB cases (DR-EPTB). Besides antibiotics, adjuvant therapy with corticosteroids has also been used to treat specific EPT…
Santana Clarissa Cunha, Silva Camila Santos, Silva Paula Rocha Dantas, Mota Scarlet Torres Moraes, Barbosa Theolis, et al.
…world challenge due to its high burden and the emergency of drug-resistant MTB. MTB employs a wide range of resistance mechanisms to escape the action of the drugs currently in use for TB treatment. These mechanisms can be classified as intrinsic or acquired and are related to my…
Kusum Sharma, Aveg Bhandari, Gowrang Kasaba Manjunath, Mona Rastogi, Aishwarya S. Babu, et al.
…nary sites, potentially influencing clinical outcomes. Poor drug penetration at these sites may cause treatment failure, even in the absence of resistance. Timely access to resistance profiles and lineage information may support more effective, personalized treatment for extrapul…
P. K. Yаblonskiy, B. I. Vishnevskiy, N. S. Solovyova, Vladimir Galkin
The objective: to assess changes in the data on drug resistance of M. tuberculosis for 2015-2021 and compare it with data for 2012-2014. Subjects and Methods. Using continuous sampling, the frequency of drug resistance of Mycobacterium tuberculosis (MTB DR) was studied in isolate…
N. Neenu, Ketaki Utpat, Unnati Desai, Susvirkar Akshay
…appropriate treatment before the correct diagnosis is made. Drug-resistant cutaneous TB should be suspected in patients with no response to first-line drugs, with clinical deterioration. We are reporting a case of a 15-year-old male with a skin lesion over the right foot who was …
Vishal Wadhwa, Rohini Kelkar, Shibani Ramchandran, Kirti Chadha, Raj Jatale, et al.
…diagnosing extrapulmonary infection and discordance between drug susceptibility reported through culture, Xpert MTB/ RIF, line probe assay require further review. Objectives were to compare positivity rate of Xpert MTB/RIF ULTRA across various sample types; compare drug susceptib…
T. D. (Tosheva) Rakhmatovna
…esent stage for the treatment of tuberculosis with multiple drug resistance. A clinical example of treatment of a patient with multidrug category 4 resistance, second-line drugs, the use of which made it possible to achieve clinical improvement, cessation of bacterial excretion a…
Tanish Modi, Kusum Sharma, Neeraj Singla, Tina Sood
We aim to study the extensiveness of drug resistance in patients of Tubercular Meningitis (TBM) in our population.
Sarika Jain Agrawal, V Mamatha, Somashekar Narasimhaiah
Objectives: Isoniazid (INH) and second-line drug resistance (DR) detection through line probe assay (LPA) takes long in extrapulmonary (EP) specimens because culture growth needs to be obtained to perform deoxyribonucleic acid (DNA) extraction due to the paucibacillary nature of …
Webster Chewe, Abidan Chansa, Patrick Lungu, Namakando Liusha
Extrapulmonary drug resistant tuberculosis (DRTB) is a rare manifestation of disseminated tuberculosis which carries high mortality more so if the central nervous system (CNS) is affected. This paper reviews two cases of extrapulmonary DR-TB, involving two males both aged 32 year…
Webster Chewe, Abidan Chansa, Patrick Lungu, Namakando Liusha
Extrapulmonary drug resistant tuberculosis (DR-TB) is a rare manifestation of disseminated tuberculosis which carries high mortality more so if the central nervous system (CNS) is affected. This paper reviews two cases of extrapulmonary DR-TB, involving two males both aged 32 yea…
Binit Singh, Pankaj Jorwal, Nishant Thakur, Manish Soneja, Naveet Wig, et al.
Abstract Background: Rapid diagnosis of drug-resistant tuberculosis (DR-TB) is very challenging, specifically in extra-pulmonary TB specimens. Methods: Current study was performed on non-sputum specimens. All specimens were subjected on Xpert MTB/RIF Ultra followed by Xpert MTB/X…