Showing 1–25 of 172 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Muhammad Kashif Munir
…attle against Koch’s disease is still being fought and that diagnostics remain the frontline weapon.1 The history of tuberculosis (TB) diagnostics is, in many ways, the history of microbiology itself. From microscopy and culture to molecular assays capable of detecting resistance…
Adam Penn‐Nicholson, Sophia B. Georghiou, Nelly Ciobanu, Mubin Kazi, Manpreet Bhalla, et al.
Abstract Background The WHO End TB Strategy requires universal drug susceptibility testing and treatment of all people with tuberculosis. However, available second-line diagnostic tools are cumbersome and require sophisticated laboratory infrastructure, and ultimately less than h…
Anaesthesia Technician and Private Practitioner, India, Berlin Francis
… the gap between conventional culture methods and molecular diagnostics, MGIT enhances diagnostic accuracy and supports global TB control strategies. This article explores the role of MGIT systems in tuberculosis detection, examines their contribution in integrating culture-based…
Gayathri Ramasubban, Joy Sarojini Michael, Richa Gupta, Kavyasri Channamaneni, Dhanabagyam Krishnan, et al.
…developed to provide efficient, accurate, and accessible TB diagnostics. This study evaluates the performance of the mfloDx ™ pre-XDR-TB test for detecting TB and drug resistance against MGIT culture and drug susceptibility testing (DST). Methodology We have evaluated the perform…
Yuliya Mikhaylova, Nadezhda Mezentseva, С. А. Стерликов, Aleksandr Mikhaylov, Yana Pankova
Significance. The system of microbiological diagnostics is of key importance for organizing microbiological diagnostics in accordance with the modern recommendations, and fulfilling political commitments of the Russian Federation within the framework of the End TB Strategy Purpos…
Eskild Petersen, David S.C. Hui, Jean B. Nachega, Francine Ntoumi, Delia Goletti, et al.
…ortant precedent for increasing access to affordable drugs, diagnostics and vaccines for other epidemic diseases affecting resource-poor countries. In April, 2021, a Brazil judge suspended drug patent extensions, a preliminary decision that could lower costs for drugs critical to…
Anthony G. Tsolaki, Amy K. Barczak, Uday Kishore
This Research Topic aimed to attract studies that would enhance our understanding of host immunity against TB and its role in both pathogenesis and protection. The submitted papers represent diverse approaches to understanding TB, from biomarker discovery and drug resistance surv…
KoziÅska,Monika, Filipczak,Dorota, Augustynowicz-KopeÄ,Ewa
…as obtained. In the course of microbiological and molecular diagnostics, conducted from June 2021 to February 2022, divergent results were obtained from drug susceptibility testing and genotyping of MTB strains isolated from clinical materials from the patient. In the final stage…
Kozińska M, Filipczak D, Augustynowicz-Kopeć E
…as obtained. In the course of microbiological and molecular diagnostics, conducted from June 2021 to February 2022, divergent results were obtained from drug susceptibility testing and genotyping of MTB strains isolated from clinical materials from the patient. In the final stage…
Mandira Varma‐Basil, Mridula Bose
Tuberculosis (TB) continues to be a major global health problem despite the fact that with timely diagnosis and appropriate treatment, most patients can be completely cured of the disease. In spite of the availability of an effective treatment regimen, 9.0-11.0 million individual…
Е. М. Жукова, Е. П. Мышкова
…d treatment regimens and express methods of microbiological diagnostics established by the Executive order #951. <b>Methods:</b> The results of treatment of patients (n=378) treated in 2014 and 2018 (years before and after the implementation of the recommendations of WHO, MoH Exe…
Shahista, Jappreet Kaur, Amit Kumar Singh, Vivek Kumar Garg
Drug-resistant tuberculosis (DR-TB) is described as tuberculosis that is not responding to one or more anti-TB medications. A person is diagnosed with DR-TB if they do not respond to regular TB treatment; then a more challenging treatment regimen and a longer treatment duration a…
Satyavratan Govindarajan, S. R. Manuskandan, Ramakrishnan Swaminathan
…tes the MDR-TB condition using CXR images, its computerized diagnostics could be used in the early screening and followup of TB ridden patients for public health infection control in any setting.
Andrea Sanchini, Alessio Lanni, Federico Giannoni, Alessandro Mustazzolu
Despite available global efforts and funding, Tuberculosis (TB) continues to affect a considerable number of patients worldwide. Policy makers and stakeholders set clear goals to reduce TB incidence and mortality, but the emergence of multidrug-resistant TB (MDR-TB) and extensive…
Zafran Khan, Daniya Ualiyeva, Khalid Jamal, Babar Ali, Fayaz Ahmad, et al.
Mycobacterium tuberculosis (Mtb) is a causative agent of the infectious disease tuberculosis (TB), which has hampered susceptible populations in modern-day societies for years. Additionally, the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strai…
Muhammad Saleem, Syed Muhammad Ishaque, Muhammad Shafee Khosa, Zia Ud Din, Nargis Haider Kakar, et al.
Introduction: Mycobacterium tuberculosis (MTB) appears resistant to first line antibiotics e.g. rifampicin and isoniazid is said to be Multi-drug resistant Tuberculosis(MDR-TB), Globally 15.3 million cases emerge where as in Pakistan 1.8 million cases reported included Pakistan i…
Lindiwe Modest Faye, Carine Bokop, Sandeep Vasaikar, Teke Apalata, Ntandazo Dlatu
Infectious illnesses have always posed a threat to human health, with tuberculosis (TB) being a major concern. The use of various medications and antibiotics in the fight against such illnesses has led to the emergence of drug-resistant infectious diseases, which have become incr…
Antonino Catanzaro, MD
The goal of this study is to evaluate time to diagnosis for three assays (line probe, pyrosequencing, and Microscopic Observation Drug Susceptibility Assay \[MODS\]) to detect resistance to first and second-line anti-tuberculosis (TB) drugs in Mycobacterium tuberculosis (Mtb) str…
John Metcalfe, Peter Bacchetti, Aliasgar Esmail, Andrew Reckers, David Aguilar, et al.
Abstract Background Treatment monitoring of drug-resistant tuberculosis (DR-TB) in resource-limited settings is challenging. We developed a multi-analyte assay for eleven anti-TB drugs in small hair samples as an objective metric of drug exposure. Methods Small hair samples were …
Michael L. Chen
The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrob…
Girija Shankar Udgata, Srikanta Dash -
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB), one of the top 10 causes of death worldwide (ranking above HIV/AIDS). About a quarter of the world's population is infected with TB and thus at risk of developing TB disease. The Global TB Repo…
Kurt Wollenberg, Michael A. Harris, Andrei Gabrielian, Nelly Ciobanu, Dumitru Chesov, et al.
Abstract Background Recurrence of drug-resistant tuberculosis (DR-TB) after treatment occurs through relapse of the initial infection or reinfection by a new drug-resistant strain. Outbreaks of DR-TB in high burden regions present unique challenges in determining recurrence statu…
Faeez Muhammad, Laiba Siddiqui, Rabbia Gul
Tuberculosis (TB) is one of the leading infectious diseases that is highly transmissible. It is reported to cause approximately 10 million infections and 1.4 million deaths globally in the year of 2019.¹ Prompt detection and treatment of TB are essential to intercept the prolifer…
Ameya D. Bendre, Pooja Singh, Swati Jaiswal
…developing new drugs and treatments, advancing vaccines and diagnostics, exploring innovative approaches for multidrug- and extensively drug-resistant TB, and investigating the molecular and genetic factors that influence mycobacterial responses to therapy, all to improve TB diag…
Ambreen Shaikh, Camilla Rodrigues
…. Nucleic Acid Amplification Tests Advances in molecular TB diagnostics over the last decade have resulted in emerging technologies for TB testing that are both accurate and fast. Molecular tests are also used to detect resistant target gene mutations. Low-complexity tests such a…