Showing 1–25 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Tulane University
Pediatric tuberculosis (TB) continues to pose diagnostic challenges in low- and middle-income countries with high rates of TB disease, due to the well-described impact of paucibacillary disease in children, and current TB culture and polymerase-chain reaction tests are of limited…
Alice Halliday, Pooja Jain, Long Hoàng, Robert Parker, Mica Tolosa-Wright, et al.
Background Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed. Objective To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain re…
Sofia Kostoudi, Robert Hammond
…aims to examine and analyze the present and proposed future diagnostics in the identification of latent tuberculosis. Design Systematic Review Methods PubMed and Scopus were scanned as primary databases during May 2022. Exclusion criteria for the papers scanned included patients …
Nsikak Godwin Etim, Tatfeng Youtchou Mirabeau, Olwayemisi A. Olorode, Miriam U. Nwodo, Sylvester Chibueze Izah
Various diagnostic methods are employed to detect tuberculosis (TB).One of the most commonly used tools is the microscopic examination of sputum samples, utilizing acid-fast staining to identify Mycobacterium tuberculosis.Chest X-rays are instrumental in identifying TB-related lu…
Jee Whang Kim, Hemu Patel, Richard Halliwell, Raman Verma, RC Free, et al.
<h3>Introduction</h3> Use of rapid molecular diagnostics such as Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert-Ultra) is endorsed by World Health Organization for rapid diagnosis of TB. Xpert-Ultra has improved sensitivity, but utility in low TB-prevalent settings, where paucibaci…
Maria Olivia Fotiou, Amelia Holloway, Anoop Kurian Mathew, Alexis Jones, Jessica Manson
Abstract Introduction Severe systemic lupus erythematosus (SLE) can present with multi-organ involvement, including respiratory manifestations. SLE can both mimic and trigger hyperinflammatory states, including haemophagocytic lymphohistiocytosis (HLH). This case describes a pati…
Declan Emegano, Nazife Sultanoğlu, Efe Precious Onakpojeruo, Berna Uzun, Dilber Uzun Ozsahin, et al.
BACKGROUND/AIMS: Latent tuberculosis infection (LTBI) remains a critical challenge in global tuberculosis (TB) control efforts, necessitating effective diagnostic techniques.This study provides a comprehensive analysis of 7 diagnostic methods for LTBI, including QuantiFERON-TB an…
Syed MA Zaidi, Anna K. Coussens, James A. Seddon, Tamara Kredo, Digby F. Warner, et al.
Abstract Background There is growing recognition that tuberculosis (TB) infection and disease exists as a spectrum of states beyond the current binary classification of latent and active TB. Our aim was to systematically map and synthesize published conceptual frameworks for diff…
Chendi Bih Hycenta, Vanessa Mwebaza Muwanga, Tracey Jooste, Martin Kidd, Simon C. Mendelsohn, et al.
<h3>Background</h3> Several host blood transcriptomic signatures have shown promise as tuberculosis (TB) diagnostic candidates, supporting the use of such biomarkers in prototype RNA-based point-of-care tests. Further validation of these signatures across different clinical and e…
Jung‐Kyu Lee, Dong-Hyun Joo, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung
<b>Backgrounds:</b> The first step in diagnosing latent tuberculosis (TB) in patients with confirmed TB infection is to exclude active TB. The currently recommended test for this is chest X-ray (CXR), with limited data on whether computed tomography (CT) can be a better alternati…
Yinghui Fu, Xue Yang, Hongyan Chen, Yugang Lu
Abstract Tuberculosis (TB) induced by Mycobacterium tuberculosis (Mtb) is a serious global health burden. This study sought to investigate the expression and diagnostic value of serum miR-145 in TB patients and explore the biological function of miR-145 using macrophages. Serum e…
Анна Старшинова, E. V. Istomina, Yulia Zinchenko, Michail Filatov, С. Б. Ланда, et al.
The diagnostic of tuberculosis infection, including the use of immunological methods, evolved significant changes. The introduction of new diagnostic tests allowed to improve the diagnosis of latent tuberculosis infection (LTI). However, the positive results of immunological test…
Linsheng Li, Zhuang Li, Ling Yang, Zhaoyang Ye, Ruizi Ni, et al.
Abstract Background Latent tuberculosis infection (LTBI) is a significant source of active tuberculosis (ATB), yet distinguishing between them is challenging because specific biomarkers are lacking. Methods We analyzed four microarray datasets (GSE19491, GSE37250, GSE54992, GSE28…
Zikun Huang, Cuifen Xiong, Qing Luo, Juxiang Zhu, Yongqin Guo, et al.
Despite efforts to control it, tuberculosis (TB) remains a significant challenge in the field of public health globally.1 Timely diagnosis of active TB is essential to control disease transmission.2 A recently discovered group of small non-coding RNAs, namely transfer RNA-derived…
Dr.Anmar Talib, Rafeef Y. Rashid Rashid
…ortant for extra pulmonary TB cases, although immunological diagnostics such as interferon-gamma release assays (IGRA) and T-spot methods that associated with the identification of latent TB infection. Although their routine use was still hindered by infrastructure and expense, e…
Hua Qiang Liu
Heat shock protein 16 kDa (HSP 16 kDa) is essential for the survival of latent Mycobacterium tuberculosis. Therefore, a peptide-MHC presentation of HSP 16 kDa could be a potential diagnostic and therapeutic target for latent tuberculosis (LTB). This study aimed to generate differ…
Xiuxiu Ji, Siyu Yao, Hongyan Jia, Qi Sun, Yingchao Wang, et al.
BACKGROUND: The World Health Organization encourages the development of novel diagnostic tools based on 'non-sputum' samples to meet global goals for tuberculosis (TB) control. We aimed to develop a machine learning-driven model for TB diagnosis, using long non-coding RNAs (lncRN…
Aman Yadav, Yasha Hasija
Tuberculosis and sarcoidosis are clinically overlap-ping granulomatous diseases that present significant diagnostic challenges, particularly when distinguishing between their subtypes. Traditional diagnostic methods often lack specificity, leading to misclassification and subopti…
Christianne Bourlon, Oscar Manuel Fierro-Angulo, Jesus A Garcia-Ramos, Rocío Camacho-Hernández, Roberta Demichelis, et al.
Introduction Latent tuberculosis infection (LTBI) affects one third of the world population. It is well known that patients with immunodeficiency are at a higher risk of developing active tuberculosis (ATBI). Hematopoietic stem cell transplant (HSCT) recipients have an incidence …
Jingyan Zhang, Qiangsen Zhong, Xiaochun Wang
Early and timely diagnosis is crucial for reducing the transmission of tuberculosis.In this study, we constructed and expressed PhoY2, a persistent infection related antigen of Mycobacterium tuberculosis and evaluated its potential as a diagnostic target through population experi…
Yuehong Xu, Xiaoying Li, Pu Liao, Changchun Niu
Abstract Background Our study aims to identify novel diagnostic biomarkers for distinguishing different infection statuses of M. tuberculosis. Methods Differential genes (DEGs) of different infection statuses of M. tuberculosis from the GEO datasets were analyzed using GEO2R. The…
Dinesh Rotake, A. Parakh, Shiv Govind Singh, Jitendra B. Zalke
An insilico diagnostic probes is designed for the detection of latent Tuberculosis caused by Mycobacterium Tuberculosis. Identification of a specific target is required to diagnose the condition of latent Tuberculosis. Till date, there is no specific detection of latent Tuberculo…
L. Kassegne, Philippe Fraisse
<title>Abstract</title> Background Most tuberculosis (TB) cases in high-income countries occur in foreign-born people, most of them coming from high incidence countries. However, migrants return more or less frequently to their birth countries. The aim of the study was to estimat…
Jungho Kim
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is a major global health concern.Approximately one-third of individuals globally harbors latent TB infection (LTBI), posing a significant challenge as 5%-10% of those infected may develop active TB, especially …
Joan Cayla, MD, Henrik Aggerbeck, M. Sc.
…C-Tb test. The TESEC-06 trial is an open comparison of the diagnostics performance of C-Tb compared to QuantiFERON®-TB Gold In-Tube, in combination with a double-blind randomized split-body safety assessment of C-Tb versus Tuberculin PPD RT23 SSI. The trial is designed to addre…