Showing 1–25 of 200 documents
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Emily MacLean, H. Manisha Yapa
… High priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting.https://www.who.int/publications/i/item/WHO-HTM-TB-2014.18Date: 2014Date accessed: February 12, 2024Google Scholar although signatures performed better than W4SS. All signatures…
David SC Hui, MD
Tuberculosis (TB) is an endemic infectious disease in Hong Kong and a global health threat. Tuberculous pleuritis (TBP) is the most common form of extrapulmonary tuberculosis in China. Its presentation is frequently non-specific and the diagnosis is challenging due to its pauciba…
Ka Pang Chan, MBChB
…tagenomic NGS (mNGS) has been applied in infectious disease diagnostics. Chang et al. have previously evaluated the use of mNGS in blood and urine samples for tuberculosis diagnostics. They revealed that such methodology is limited by the low MTB concentration and the background …
Elin Folkesson
…nd post-treatment cure. These approaches could transform TB diagnostics, reduce diagnostic delays, and support global TB elimination efforts.</p><h3>List of scientific papers</h3><p dir="ltr">I. A protein signature associated with active tuberculosis ident…
Elin Folkesson
…nd post-treatment cure. These approaches could transform TB diagnostics, reduce diagnostic delays, and support global TB elimination efforts.</p><h3>List of scientific papers</h3><p dir="ltr">I. A protein signature associated with active tuberculosis ident…
Barkha Vimal, Saurabh Purohit, Albail Singh Yadav
Background: Abdominal tuberculosis (TB) remains a significant diagnostic challenge due to its nonspecific presentation and the limited sensitivity and specificity of conventional diagnostic modalities such as ultrasonography (USG) and contrast-enhanced computed tomography (CECT).…
R. Nath, Pranav Ish, Kumari Harshita, Ashish Sethi
…acillary loads, which lower the sensitivity of conventional diagnostics.[7] AI models trained on diverse datasets may help detect subtle radiological or clinical patterns, thus improving case detection in this vulnerable subgroup. Molecular diagnostics are also being transformed …
All India Institute of Medical Sciences
The goal of this Diagnostic accuracy study is * To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and * To study the correlation of imaging findings in tubercular meningitis and spinal tubercular arachnoiditis with clinical out…
Justin Onyebuchi Nwofe, Laura Madukaji, Daniel Chinenyeike Offie, Dickson Adeolu Adetoye, Emmanuel Adewale Ojo, et al.
Abstract Introduction Tuberculosis (TB) diagnosis remains the weakest link in the care cascade, particularly among people living with HIV and AIDS (PLHIV) with advanced HIV disease (AHD), who are often cannot produce quality sputum for standard tests. Urine-based assays such as D…
Harriet N. Garlant, Kalaiarasan Ellappan, Noyal Mariya Joseph, Carrie Turner, Vishnukanth Govindaraj, et al.
…et Product Profiles (TPPs) call for rapid, non-sputum-based diagnostics with high sensitivity and specificity. This study evaluates our previously published TB-associated host-immune biomarkers alongside small-size signatures from other studies, in our previously published non-hu…
Rangasamy Ramanthan, M. Jayapritha
…ngs, to improve TB detection. Expanding access to molecular diagnostics and integrating nutritional interventions are essential for better management.
Ganesh Kumar Verma, Muniba Alim, Ramesh Chand, Vinay Verma, Himanshu Gupta
BACKGROUND: Tuberculous meningitis (TBM) remains a leading cause of morbidity and mortality in children, particularly in endemic regions. Early diagnosis is crucial for optimal outcomes, yet remains challenging due to nonspecific clinical presentations and limited diagnostic sens…
E. Yu. Nosova, M. A. Sviridenko, Anastasia Khakhalina, Ksenia Galkina, Yu. D. Mikhailova, et al.
…8 patients (including HIV-infected ones) requiring rapid TB diagnostics. The study was conducted from one portion of the sediment of the diagnostic sample using bacteriological methods (luminescent microscopy, cultivation on Middlebrook 7H9 medium in the Bactec MGIT 960 system an…
Anchu R Nath, Nayanabai Shabadi, И. М. Сон, P V Manirsha
…andardized diagnostic algorithms, and integrating molecular diagnostics are essential to improve patient care. A multidisciplinary and collaborative approach is recommended to overcome existing barriers.
MBBS, MD, Navakumar Manickam
Cutaneous tuberculosis (CTB) is a rare form of extrapulmonary tuberculosis, accounting for less than 2% of all TB cases. Its atypical presentations, which deviate from the classical forms like lupus vulgaris and tuberculosis verrucosa cutis, pose significant diagnostic challenges…
Upasana Das, Kalyani Prava Gauda, Indrani Mohanty, Atanu Kumar Bal, Sasmita Hotta
Introduction: Infection with tuberculosis is a worldwide health concern. Nearly every organ in the body can be affected by Extrapulmonary Tuberculosis (EPTB). A simple diagnosis of Pulmonary Tuberculosis (PTB) can be made using radiography and a positive sputum test. On the other…
Shani Abidi, Handri Andika
Background: Tuberculosis (TB) remains a major global health challenge, with its variable clinical presentations often complicating timely and accurate diagnosis. Diagnostic imaging modalities such as chest X-ray, computed tomography (CT), magnetic resonance imaging (MRI), and pos…
Christine Tzelios, Ruvandhi R. Nathavitharana
…OHigh-priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting. World Health Organization, Geneva2014Google Scholar Above this sensitivity threshold, the receiver operating characteristic curves did not differ significantly between the five…
Aditya Kumar Jha
…ar microscopy and culture have low sensitivity, so advanced diagnostics like PCR, histopathology, FNAC, and Xpert MTB/ RIF are needed. This study aimed to assess the clinical features and diagnostic accuracy of these methods in smear-negative cervical tuberculous lymphadenitis. M…
Tamer A. Addissouky
…Short conclusion A multifaceted approach combining advanced diagnostics, optimized therapeutics, and strategic prevention is essential for addressing the global ITB burden. Future research should focus on developing point-of-care diagnostics, personalized treatment protocols, and…
Sohail Hussain, Faiza Nafees Khan, Aimen Noor Ul Ain, Momina Shahid, Imtiaz Begum, et al.
Abstract Background Tuberculosis (TB) of the abdomen is a rare form of extrapulmonary TB with indeterminate symptoms that are commonly mistaken for malignancies, leading to substantial diagnostic problems. This report describes the intricacies of diagnosing abdominal TB and empha…
Imane Chaoui, Samir Taoudi, Amal Oudghiri, J. Benamor, J.E. Bourkadi, et al.
…a very common form of extrapulmonary tuberculosis (TB). pTB diagnostics represents a major burning challenge worldwide due to the limitations of available conventional diagnostic tools. These latter include microscopic examination of the pleural fluid for acid-fast bacilli, mycob…
Muhammad Ahmad Raza, Muazzam Tufail, Laamia Altuf, Kinza Chaudhary, Sidra Ghazanfar, et al.
Background: Central nervous system infections (CNSIs) are a significant cause of morbidity and mortality globally. Accurate diagnosis is crucial for effective management and improved outcomes.Objective: To determine the diagnostic accuracy of magnetic resonance imaging (MRI) for …
Seiwon Lee
It is intended for patients who have been admitted to the outpatient or emergency room or are hospitalized For patients who diagnose pulmonary tuberculosis or extrapulmonary tuberculosis using Xpert TB/RIF, additionally, diagnose pulmonary tuberculosis or extrapulmonary tuberculo…
Murwan Mohamed Saeed, Laila Sulman AbdElrhman
Background: Tuberculosis is an infectious caseating granulomatous disease that cause by mycobacterium mainly mycobacterium tuberculosis and mycobacterium bovis, it is a systemic disease that effect any body organ, but mainly affect the lung. EHO classified tuberculosis into pulmo…