Showing 1–25 of 116 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Helen McShane
…ce strong cellular immune responses in humans using subunit vaccines. DNA vaccines induce both CD4+ and CD8+ T cells and thus offer a potential new approach to a TB vaccine. DNA vaccines encoding various antigens from M. tuberculosis have been evaluated in the murine model, and t…
Ben Morton, MD. MPH, MBChB
…us disease and the body's response and can help develop new vaccines and treatments. The purpose of this study is to set up a human challenge model using BCG to understand how the body responds to this. If our human challenge model works well it may be used to help researchers de…
GS Shepelkova, Vasiliy Reshetnikov, VG Avdienko, DV Shevyrev, VV Yeremeev, et al.
…aimed to compare the capabilities of three variants of mRNA vaccines encoding Esat6 epitopes of stimulating adaptive immune response formation in C57BL/6 mice (ELISpot, delayed hypersensitivity, IgG titers), as well as of protecting I/St mice against M. tuberculosis infection. Ef…
Mario Tovar, Joaquín Sanz, Yamir Moreno
…s 2B and 3 of the development pipeline. The impact of these vaccines on the general population needs to be addressed using disease-transmission models, and, in a country like China, which last year ranked third in number of cases worldwide, and where the population is undergoing …
Tjip S van der Werf, MD PhD
Prospective, randomized, double-blind, multicentre, placebo-controlled clinical phase IIa trial to evaluate safety and immunogenicity of RUTI® vaccine in Multidrug-resistant Tuberculosis (MDR-TB) patients favourably responding to standard MDR-TB treatment. Time point of vaccinati…
Eva Morgun, Jennifer Zhu, Sharan Bobbala, Melissa S. Aguilar, Junzhong Wang, et al.
…ant strains, an efficacious vaccine solution is imperative. Vaccines currently being developed for Mtb utilize protein antigens, which target MHC-restricted conventional T cells, overlooking the potential of Mycobacterium tuberculosis (Mtb) lipid antigens such as mycolic acid (MA…
Arpita Batta, Vineeta Singh, Bhartendu Nath Mishra, Tapankumar N. Dhole, Prahlad K. Seth
The aim of this study was to predict promiscuous vaccine candidates against Mycobacterium tuberculosis (MTb) using in silico reverse vaccinology. Antigenic peptides from selected MTb strain LJ319 (4,025 proteins) were analyzed by various immunoinformatics tools; from which 165 ou…
Vikas Jha, Kunal Gharat, Joshua Koli, Ashish Jhangiani, Vrushali Dhamapurkar, et al.
…ne technology aims to accelerate the development of subunit vaccines by identifying specific proteins in a pathogenic bacterial proteome that may be protective antigens. This approach was employed on four extracellular proteins namely Secreted fibronectin-binding protein C antige…
Ayan Mukherjee, Sukhen Samanta, Molla Zakirul Haque, Partha Sarathi Jana, Arun K. Das, et al.
Bovine tuberculosis (bTB) is a severe infectious disease that affects both domesticated and wild animals and has a negative impact on both public health and the global economy. The causative organism of the disease is Mycobacterium bovis and, sporadically, other pathogenic mycoba…
Randeep Guleria, Prof
Prospective, randomized, double-blind, multicentre, placebo-controlled clinical phase IIb trial to evaluate efficacy of RUTI® vaccine in DS- (Drug-Sensitive) and MDR-TB (Multidrug-resistant) patients favourably responding to standard MDR-TB treatment. Time point of vaccination st…
Jesús Gonzalo‐Asensio, Nacho Aguiló, Dessislava Marinova, Carlos Martı́n
Tuberculosis (TB) is the biggest killer of humanity. TB has killed more human beings than any other infectious disease in history, with an estimated loss of over a billion lives in the past 200 years (1). Despite effective treatment, in the WHO 2016 there were an estimated 10.4 m…
Chathika K. Weerasuriya, Rebecca C. Harris, Christopher Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, et al.
The original article contained errors in the Abstract which have all since been corrected.
Penny M. Heaton, Jeffrey S. Barrett
…scribes some of the institute's work on candidate drugs and vaccines against tuberculosis, the leading infectious diseases killer in the world. The Bill & Melinda Gates Medical Research Institute (Gates MRI) is a nonprofit biotechnology organization focused on diseases that dispr…
Ally Yeketi Ayinla
This project analyses the tuberculosis (TB) epidemic mathematically using compartmental modelling approach. Three models are presented to discuss drug susceptible and multi-drug resistant TB. The first model presented has 4 compartments; susceptible, exposed, infectious and recov…
Aishwarya Venkataraman, MRCPCH
…cille Calmette Guerin (BCG) vaccine is one of the most used vaccines of the world, to reduce the risks of natural tuberculous infection. The efficacy of BCG vaccination in newborns is well known and has a documented protective effect against meningitis and disseminated TB in chil…
Ana Alvarez, Mobeen H. Rathore
Data from clinical and epidemiological studies have led to several new recommendations in the areas of diagnosis and treatment of pediatric tuberculosis in the past few years. Due to the low incidence of tuberculosis in the United States, many primary care providers may not be fa…
О. М. Raznatovska, A. S. Moskaliuk, Тетяна Анатоліївна Грекова, L. I. Chernyshоva, O. O. Pushnova, et al.
BACKGROUND. The World Health Organization (WHO) reports an unknown contact history of pediatric tuberculosis (TB), especially in children younger than 5 years old. Tracing pediatric household contacts of patients with multidrug-resistant TB (MDR-TB) is considered to be a highly e…
Afifah Machlaurin
Tuberculosis (TB) was the leading cause of death due to infectious diseases. In Indonesia, TB incidence and mortality are still very high. Immediate steps to scale-up preventive, diagnostic, and treatment services for TB, specifically among hard-to-reach populations, were priorit…
Anna Cristina Calçada Carvalho, Afrânio Lineu Kritski
Tuberculosis in children (younger than 15 years) has often been considered a minor problem by national tuberculosis programmes. The low bacterial load of tuberculosis in children, which confers a lower risk of disease transmission,1Marais BJ Gie RP Schaaf HS et al.The natural his…
Saumya Sagar, Anupam Prakash
…rch and development for better diagnostics, treatments, and vaccines often lag. For example, India is one of the major countries carrying the world’s filariasis burden, mostly spread across the western and eastern coastal borders. Yet, just recently, the national programme has be…
Gülşen Akkoç, Seyhan Yılmaz, Sevgi Aslan Tuncay, Aylin Dizi Işık, Pınar Canizci Erdemli, et al.
Background: Tuberculosis (TB) remains a major cause of morbidity and mortality, with children primarily infected through close contact with adults. Data on household transmission in children in Türkiye are limited.Objective: This study aimed to determine the prevalence of latent …
Z.I. Pіskur, O.P. Kostyk, M.І. Sakhelashvili, L.І. Pylypiv, O.M. Shvets, et al.
Objective — to analyze the peculiarities of detection and course of various clinical forms of extrapulmonary tuberculosis (EPTB), the profile of drug resistance of the Mycobacterium tuberculosis (MBT) among children of different ages. Materials and methods. We retrospectively an…
Mohau S. Makatsa
Tuberculosis (TB) remains the infectious disease causing the greatest global mortality, with an estimated 10 million incident cases of TB and 1.45 million deaths in 2018. Although there is a cure for TB, the success of the treatment is hampered by multidrug resistant TB and HIV i…
Mockeliunas, Laurynas
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Each year, more than 10 million people are estimated to develop TB, and over 1.2 million die from the disease, and resistance to drugs is a major challenge. Another infectious disease, coronavirus di…
Kamath Madhusudhana
…um tuberculosis. Thatis about 2 billion people. Several new vaccines will pass Phase I clinical trials in the next few years. Thispaper briefly summarizes past and present challenges to developing a vaccine against tuberculosis as well astreating tuberculosis. TB is a pathogen th…