Showing 1–25 of 200 documents
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Wenping Gong, Jianping Xie, Hao Li, Ashok Aspatwar
…prevention of COVID-19, and the latest progress of novel TB vaccines.BCG: Old tree sprouts new budsAlthough BCG vaccination can effectively protect infants and young children from M. tuberculosis infection, especially in the prevention of severe TB diseases such as disseminated t…
Mohamed E. El Zowalaty, Hossam M. Ashour
…able protection. Currently, there are at least 16 candidate vaccines in various stages of clinical development in the global TB vaccine pipeline, as was reviewed elsewhere.2TuBerculosis Vaccine Initiative (TBVI)Pipeline of Vaccines.https://www.tbvi.eu/what-we-do/pipeline-of-vacci…
N.А. Matsegora, A.V. Kaprosh
…uding the AEC/BC02, Ad5 Ag85A and ChAdOx185A-MVA85A phase 1 vaccines, MTBVAC, ID93+GLA-SE, TB / FLU-04L and the GamB phase vaccine. 2a, amplifiers DAR-901, H56:IC31, M72/AS01, BCG revaccination and RUTI vaccine in phase 2b, VPM1002 and MIP/Immuvac in phase 3. Candidate TB vaccine…
Zhou Xing, PhD, Fiona M Smaill, MD
The purpose of this Phase 1 study is to evaluate the safety and immune responses of a new tuberculosis vaccine, Ad5Ag85A, administered to healthy volunteers. 48 subjects will be recruited, 24 who have previously been vaccinated with BCG and 24 who have not received BCG vaccine. T…
Kendra Brett, Melissa Severn
… general use, and it is one of the most widely administered vaccines. Nevertheless, there are still some questions with regards to the effectiveness of the BCG vaccine, particularly, the duration of the effect, and the ability to protect against pulmonary TB in adults. A global r…
Fan Jiang, Lingling Wang, Jie Wang, Peng Cheng, Jing Shen, et al.
…ics techniques in designing safe and effective tuberculosis vaccines.
Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
The study is aimed to evaluate the safety and immunogenicity of the medicinal product "GamTBvac" - a recombinant subunit vaccine against the tuberculosis. The study is designed as a comparative placebo-controlled study with a two-fold increase of an applied dose among healthy vol…
Irina V. Lyadova, A. A. Starikov
The spread of the novel coronavirus infection (COVID-19) makes the search for new approaches to prevent the infection of great importance. As one of the relevant approaches, the vaccination of risk groups with BCG vaccine has recently been suggested. BCG (Mycobacterium bovis, Bac…
Wenping Gong, Ashok Aspatwar, Jianping Xie, Hao Li
…f reduced bacterial burden in primates.• Argued that future vaccines must be designed to elicit a precisely tuned humoral immune response. • Corrected errors in the labeling of figures in the supplementary materials.• Confirmed that the corrections do not affect any experimental …
Chacon, Alexis
…not recommended for PLWH. Thus, the development of novel TB vaccines, which are safe and effective in PLWH, remains an urgent global necessity. We have found that humanized mice (hu-mice) are ideal models to research this as they can be successfully infected with HIV, TB and HIV/…
E Freire Rodrigues, Andreia Leite, M Cabral, G Duarte, Ana Paula Lerner Marques, et al.
Abstract Issue Tuberculosis (TB) incidence in Portugal is < 20/100000 people, with high-incidence municipalities in urban areas such as Amadora. In 2016, the national vaccination programme moved the BCG vaccine from universal to restricted risk groups. Amadora, due to the …
Л. Н. Мотанова, M. N. Kudrya
Introduction . BCG vaccination is included in the vaccination schedules of many countries. Numerous studies show its high efficacy, especially in regions with a high prevalence of the disease, and the limited efficacy of revaccination. The objective of the study : to estimate the…
Angelique Luabeya, MD
This is a Phase I, open-label, dose-escalation study with three study groups. This study will be conducted in 25 HIV negative subjects, 17 of whom will have Latent Tuberculosis Infection (LTBI) and 8 of whom will not have LTBI at study enrollment. The investigational product is A…
Ian Toma, MD, PhD
Maternal infections affect the basal immune status of neonates. One of the possible mechanism is the fetomaternal microchimerism, in which some cells and active substances are exchanged bi-directionally between maternal and fetal circulation through placenta. Even in the absence …
Xiaofang Zhao, Caihong Guo, Lianwen Wang, Zhijun Liu
…TB in adults varies significantly. Currently, six candidate vaccines aimed at preventing or delaying the progression from LTBI to active TB have advanced to Phase III clinical trials, among which the novel M72/AS01E candidate vaccine elicits a sustained immunogenicity with a prot…
Z. Mohamed, R.H. Pando, Mohd Nor Norazmi
Background: New effective tuberculosis (TB) vaccines are urgently needed to control the disease which infects about 10 million people and kills about 2 million people annually. The existing TB vaccine, Bacille Calmette Guerin (BCG), is the only available licenced vaccine which is…
E. M. Bogorodskaya, D.А. Kudlаy, L. V. Slogotskaya
…. The article presents data on development of new candidate vaccines and mechanisms of their effect on various parts of the immune system. Candidate vaccines are of particular interest, these candidate vaccines are used not only for prevention before infants are exposed to the in…
Kailong Zhao, Zhijun Liu, Caihong Guo, Huili Xiang, Lili Liu, et al.
In China, approximately 350 million people with latent tuberculosis infection (LTBI) are the major source of new TB cases, meanwhile, BCG vaccination for newborns and children under five fails to fully arrest the TB epidemic due to the mechanisms of vaccine failure. It is expecte…
Sam Ebenezer Rajadas, Vignesh Sounderrajan, Rajendran Amarnath Prabhakaran, Ragini Agrawal, Lavanya Jeyadoss, et al.
Abstract Background Vaccine development against tuberculosis remains a global health imperative, necessitating robust immunogenicity and safety profiles. Nanoparticle-based delivery systems offer promising avenues to enhance vaccine efficacy while ensuring tolerability. This stud…
Pere-Joan Cardona, MD, PhD, Joan Costa, MD, PhD
The aim of this study is to evaluate the safety of a new vaccine against Tuberculosis (RUTI) when administered to healthy adult volunteers, compared to placebo; and determine its safe dosage range. An initial evaluation of immune responses to the vaccine compared to placebo will …
Videlis Nduba, Anna H. van’t Hoog, Annefleur de Bruijn, Ellen M.H. Mitchell, Kayla Laserson, et al.
Abstract Background: Adolescents are a prime target group for tuberculosis (TB) vaccine trials that include prevention of infection (POI). The BCG vaccine is given at birth and does not prevent TB infection. TB infection, a critical endpoint for POI vaccine trials would need to b…
Julio HR Croda, PhD
In the last decade, the incidence of tuberculosis (TB) has declined in much of the world, but has increased in Central and South America. Since 2000, the prison population in these localizations has grown by 206%, the highest increase in the world. In the same period, the reporte…
Hüseyin Aytaç Erdem, Gamze Şanlıdağ, Ece Çınar, Melike Yaşar, Hüsnü Pullukçu, et al.
While severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to spread rapidly worldwide, some issues such as the uncertainty of the disease progress, whether intensive care will be needed, and risk classification are still important for clinicians. It is notable …
Fatima Abbas Khalid, Muataz Mohamed Eldirdery, Maowia M. Mukhtar
Abstract Background Tuberculin skin test (TST) is a delayed hypersensitivity reaction of latent TB infected patients and BCG vaccinated individuals. It is recommended for screening of mycobacterium infection in many countries. Kassala state in eastern Sudan is known as the highes…
Sudhasini Panda, Jeffrey Morgan, Catherine Cheng, Mayuko Saito, Robert H. Gilman, et al.
…he challenge in advancing tuberculosis (TB) diagnostics and vaccines arises from our limited understanding of diverse Mtb antigens triggering distinct T cell responses in spectrum of TB infection. We addressed this with a comprehensive analysis, screening 20,610 Mtb-derived T cel…