Showing 1–25 of 95 documents
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Daifulah Al-Zahrani
Tuberculosis (TB) is considered by WHO as a worldwide wellbeing crisis in 1993. In 2011 33% of the total populace was believed to be contaminated with TB and 8.7 million instances of dynamic TB every year. BCG antibody is one of the successful control measures to forestall TB. It…
Helen McShane, Dr
…ce strong cellular immune responses in humans using subunit vaccines. DNA vaccines, recombinant viral vectors and protein/adjuvant combinations all induce both CD4+ and CD8+ T cells, however none of these antigen delivery systems induce high levels of antigen specific T cells, wh…
Eloise T. M. Filardi, Roberto Carlos Cruz Carbonell, Fernando R. Pavan, Felipe A. Cerni, Manuela B. Pucca
Vaccines represent one of the most significant achievements in medical science, constituting safe preparations or substances developed with the primary purpose of stimulating the immune system (1,2). Their central function is to protect the human body against a myriad of infectio…
François Spertini
…t" vaccination strategies, in which two different candidate vaccines expressing antigens in common are given weeks or months apart, have generated strong and sustained cellular immune responses correlating with an M.tb protective effect in preclinical animal models. In such a "pr…
Mark Hatherill, MD, FCPaed
…as been excluded. Clinical trials of new viral-vectored TB vaccines, including MVA85A, a modified vaccinia virus Ankara (MVA) vaccine expressing the Mycobacterium tuberculosis antigen 85A, have to date enrolled infants who were already vaccinated with routine BCG at birth. Howev…
Rajesh Kumar Radhakrishnan, Abhinav Vankayalapati, Olamipejo Durojaye, Padmaja Paidipally, Ramakrishna Vankayalapati
…o adults. Funding Sources NIH, CRDF Global Topic Categories Vaccines and Immunotherapy (VAC)
Chiara Tersigni, Luisa Galli
…bMed Scopus (13) Google Scholar]. Up to now, several new TB vaccines are in the pipeline with incomplete results regarding safety and efficacy in the pediatric age [[9]Schrager L.K. Vekemens J. Drager N. et al.The status of tuberculosis vaccine development.Lancet Infect Dis. 2020…
Dženan Kovačić, Adna Softić, Adna SALIHOVIĆ, Jovana Jotanović, Sarah Maris Hotić
…file across a wider population. To this end, the novel mRNA vaccines were proven to elicit immune responses against bacterial pathogens; by virtue, the technology may be applied in bacterial infection treatment. Meanwhile, no approved mRNA prophylactics for bacterial infections e…
Videlis Nduba
…evere adverse effects in immunocompromised individuals. New vaccines are key to the global effort to eliminate TB. New vaccines will need to protect against pulmonary, extrapulmonary and disseminated TB in all populations and are urgently needed. A vaccine strategy that targets a…
Thomas E. Tavolara, Muhammad Khan Niazi, Gillian Beamer, Metin N. Gürcan
Individual factors that lead to susceptibility to Mycobacterium tuberculosis infection among humans and animal models are not clearly defined. As a result, clinicians and scientists have little ability to diagnose and prognose the various clinical manifestations of tuberculosis, …
Muhammad Abdir Rahman Albarok, Muhammad Faris, Anang Endaryanto, Retno Asih Setyoningrum
Highlights: The Bacillus Calmette-Guérin (BCG) vaccination has been widely implemented in Indonesia, but cases of spinal tuberculosis (TB) in children can still be found. There are significant and moderate relationships between BCG vaccination and the occurrence of spinal TB in c…
Usama Sajjad, Khalid Khan Niazi, Gillian Beamer, Metin N. Gürcan
Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (M.tb), poses a substantial global health challenge, affecting over 2 billion individuals worldwide. Although the approved vaccine against TB, <i>M. bovis</i> Bacille Calmette-Guerin (BCG), successfully prevents TB me…
Muhammad Yasir, Khalid Basheer, Bilal Aslam, Marium Faiz
…anufacturer. Ascertaining the relative effectiveness of BCG vaccines from different producers may have implications when setting national and global policy, as use of strains that offer superior protection may be more cost-effective
Bibi Aalia, Syed Sajid Hussain Shah
OBJECTIVE: To assess for the neurological complications and Bacille Calmette-Guerin (BCG) vaccination status of children with tuberculosis meningitis (TBM). METHODS: This retrospective study was conducted in Ayub Teaching Hospital, Abbottabad, Pakistan. Data of diagnosed case of …
Srinivasa Arer
Background: Childhood tuberculosis is largely underestimated due to diagnostic difficulties and non-specific clinical manifestations, even in many tertiary care hospitals. With increase in coverage of BCG vaccination and improved nutritional status in children, modified clinical …
Gloria G. Guerrero, Rogélio Hernández‐Pando
…individuals. There are several new promising candidates for vaccines to replace or boost BCG-induced immunity. Several evidences exist from humans and mice on the role of the trained innate memory of monocytes and NK cells, on the second encounter with the same mycobacterial path…
Saeed, N., Al Ansari, H., Al Khawaja, S., Nasser, K., Al Yousef, E.
… from 1990 to 2013,before and after the introduction of new vaccines.Of 1455 reported cases of meningitis during the study period 73.1% were viral and 26.9% were bacterial etiology [tuberculous meningitis 8.3%;Streptococcus pneumoniae 4.9%,Haemophiius influenzoe 3.6% and Neisseri…
Shamaeel, Farzana Shiakh, Ghulam Shabbir Laghari, Yasmeen Memon
Objectives: To determine the frequency of BCG vaccination in children with tuberculous meningitis of age 01 to 12 years at Liaquat University Hospital Hyderabad. Study Design: Cross sectional descriptive study. Setting: Department of Pediatrics, Liaquat University Hospital, Jamsh…
Omair Mazhar, Sher Alam Khan, Muhammad Arsalan Qaisar, Zafar Iqbal Bhatti, Mahwish Akhtar Qureshi, et al.
Aim: The purpose of the study was to govern the incidence of various forms of tuberculosis and the status of BCG vaccination in children. Study design: A Cross-sectional study. Place and Duration of the Study: In the Pediatrics department of Jinnah hospital, Lahore for one-year d…
Wünsch Filho, V., de Castilho, E. A., Rodrigues, L. C., Huttly, S. R.
Helen McShane
…ce strong cellular immune responses in humans using subunit vaccines. DNA vaccines, recombinant viral vectors and protein/adjuvant combinations all induce both CD4+ and CD8+ T cells, however none of these antigen delivery systems induce high levels of antigen specific T cells, wh…
Stephen Gordon, MD
…uberculosis (TB). Efforts to come up with new and effective vaccines have not been successful. Partially, the lack of suitable disease models and protection correlates hinders the research of new vaccines. Controlled human infection model studies (CHIM) involve administering dise…
Mark F. Cotton, Helena Rabie
…ull Text Full Text PDF PubMed Scopus (35) Google Scholar As vaccines able to prevent pulmonary tuberculosis in children and adults remain elusive and are being actively studied, there is much interest in whether repeat BCG immunisation can fulfil this role. In The Lancet Global H…
Beatrice Napoli
Tuberculosis (TB) still represents one of the leading diseases globally, causing significant morbidity and mortality. Among the possible approaches to the disease, vaccination has been considered the most important measure for its prevention. Nowadays, it comprises the use of the…
Lyudmila Ilyinichna Kaspruk
According to the formula presented by WHO, it is possible to prevent and stop the development of an epidemic of an infectious disease only when at least 90 % of the population is covered by vaccination against this type of pathogen, provided that at least 95 % of vaccinated perso…