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World Health Organization
BioNTech Responsible Person
…aluate up to four dose levels of the BNT164 investigational vaccines (BNT164a1 and BNT164b1) to select a safe and tolerable dose in a three-dose schedule. This study includes: Part A (Phase Ib) and Part B (Phase IIa). In Part A, enrollment for BNT164a1 and BNT164b1 will be cond…
Peter Aaby
The World Health Organization (WHO) currently recommends BCG vaccination at birth in developing countries. Pre-term infants should be vaccinated when they reach the chronological age of 40 weeks. Due to difficulties in establishing the correct gestational age, the vaccination pol…
Mario Tovar, Yamir Moreno, Joaquín Sanz
Abstract In the development of vaccines against tuberculosis (TB), a number of factors represent burdensome difficulties for the design and interpretation of randomized control trials (RCTs) of vaccine efficacy. Among them, the complexity of the transmission chain of TB allows th…
Ochran Chetty, Cohen Chetty
… provide an overview of the clinical status of candidate TB vaccines and discuss the challenges and future development trends of novel TB vaccine research, in combination with a general overview of the Tuberculosis (TB) disease and Mycobacterium tuberculosis itself. Methods: Bibl…
Steven C. Derrick
ABSTRACT Our goal is to develop a pediatric combination vaccine to protect the vulnerable infant population against human immunodeficiency virus type 1 (HIV-1) and tuberculosis (TB) infections. The vaccine consists of an auxotroph Mycobacterium tuberculosis strain that coexpresse…
Aisenstat, Maximilian J A
Vaccines are an important tool for maintaining global health and preventing widespread disease. Many vaccines are liquid presentations that must be kept frozen until use, which are then thawed and administered via parenteral injection. While this approach has been successful, cha…
Daphne T. Lianou, Charalambia K. Michael, Efthymia Petinaki, Vasia S. Mavrogianni, George C. Fthenakis
…sheep and goat farms, respectively. The increased number of vaccines administered was associated with a higher average milk production in the respective farms. There was an association of vaccination against staphylococcal mastitis with a reduced recovery of staphylococci from th…
Zhuang Li, Yilu Zhao, Ling Yang, Linsheng Li, Zhaoyang Ye, et al.
Tuberculosis (TB) is a global infectious disease posing a serious threat to human health, caused by Mycobacterium tuberculosis (MTB) infection. Although vaccination is the most effective way to prevent and control TB, the existing Bacillus Calmette–Guérin (BCG) vaccine exhibits l…
Naoto Kuroda
…tizens is necessary. If infants in Japan do not receive BCG vaccines, tuberculosis might spread. We must prevent this from happening by publicizing inadequate evidence of causality between the BCG and prevention of the COVID-19. We also need to highlight the concern that a shorta…
Yu Hwa Choi
The purpose of this study is to evaluate safety, immunogenicity of ID93+GLA-SE compared to placebo following three intramuscular (IM) injections on Days 0, 28 and 56 in BCG-vaccinated QFT-negative healthy adolescent. The healthy adolescent will all have had the childhood TB vacci…
Yu Hwa Choi
The purpose of this study is to evaluate the experimental tuberculosis (TB) vaccine called ID93+GLA-SE. The safety, immunogenicity, and efficacy of ID93+GLA-SE will be compared to placebo, after three intramuscular (IM) injections one month apart in healthy healthcare workers. Th…
Azar Najafi, Nahid Mahdian, Bahman Yousefi, Mohsen Karbalaei, Ali Kermanjani, et al.
…d in vivo examinations, such as recombinant BCG (rBCG), DNA vaccines, and subunit vaccines. Factors, such as applicability of vaccine candidates in all individuals, cost-effectiveness, long-term immunity and stimulation of a wide range of responses are important factors. Now, mos…
Helen McShane
The dose of recombinant MVA used in the TB trials to date is relatively low compared with other trials using recombinant MVAs which have used up to 2.5 x 108pfu (A Hill, personal communication). Having demonstrated safety and immunogenicity of 5 x 107pfu of MVA85A, we now need to…
E Kırımi, Grace Gakii Muthuri, Cyrus Gitonga Ngari, Stephen Karanja
Numerous prevention intervention strategies have been developed to curtail the spread of pulmonary tuberculosis to susceptible populations. However, pulmonary tuberculosis continues to claim many lives worldwide. In this paper, a deterministic mathematical model incorporating an …
Helena Beckhäuser Ubaldo, Ketley Schnorrenberger, Líris Besen Wolniewicz
…dhood. Thus, analysis of vaccination coverage (VC) of these vaccines and its relationship with pertussis cases in children under one year may indicate the effectiveness of these strategies. To evaluate VC of dTpa in pregnant women and pentavalent vaccine, and its correlation with…
Helena Beckhäuser Ubaldo, Ketley Schnorrenberger, Líris Besen Wolniewicz
…dhood. Thus, analysis of vaccination coverage (VC) of these vaccines and its relationship with pertussis cases in children under one year may indicate the effectiveness of these strategies. To evaluate VC of dTpa in pregnant women and pentavalent vaccine, and its correlation with…
Samaila Aboubacar, Soumana Alido, Kamayé Moumouni, Mamoudou Abdou Djafar, Garba Moumouni, et al.
Introduction: Tuberculosis remains a public health problem worldwide. The BCG vaccination is one of response means. The objective of this work was to study impact of BCG vaccination on morbidity and mortality related to childhood tuberculosis in Niamey. Patients and methods: It w…
Constanza Estefanía Martínez-Olivares, Vasti Lozano-Ordaz, Dulce Mata‐Espinosa, Jorge Barrios‐Payán, Angel E. Ortiz-Cabrera, et al.
… aimed to experimentally validate these peptides as subunit vaccines by determining their cytotoxicity, immunogenicity, and protective efficacy against Mycobacterium tuberculosis (Mtb) in mice when administered as a booster to BCG vaccination. Mice were vaccinated with BCG and, t…
Ian Links, Laurence J. Denholm, Marilyn Evers, L. Kingham, Robert J. Greenstein
BACKGROUND: Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne's disease (or paratuberculosis), a chronic wasting disease of ruminants and other animals resulting from granulomatous enteritis. There are increasing concerns that MAP is zoonotic. The prevalence of Johne…
Dana Ştefana Popescu, Anca Deleanu, Gindrovel Dumitra
Vaccine coverage for vaccines provided through the National Immunization Program is an element that is evaluated annually, including in Romania. Unfortunately, with the exception of the tuberculosis vaccine which has an optimal vaccine coverage (over 95%) both in total and in ar…
Samaila Aboubacar, Soumana Alido, Kamayé Moumouni, Mamoudou Abdou Djafar, Garba Moumouni, et al.
Introduction: Tuberculosis remains a public health problem worldwide. The BCG vaccination is one of the response means. The objective of this work was to study the impact of BCG vaccination on morbidity and mortality related to childhood tuberculosis in Niamey. Patients and metho…
Ian Links, Laurence J. Denholm, Marilyn Evers, L. Kingham, Robert J. Greenstein
Abstract Background Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne’s disease (or paratuberculosis), a chronic wasting disease of ruminants and other animals resulting from granulomatous enteritis. There are increasing concerns that MAP is zoonotic. The prevalence …
François Spertini, MD
…ion in inducing protection against tuberculosis (TB). Novel vaccines are essential to fight against the current world epidemics in tuberculosis and resistance to anti-TB drugs. A randomized, double-blind, controlled Phase I study conducted at CHUV, Lausanne, Switzerland, to comp…
Laura Sibley, Andrew White, Karen E. Gooch, Lisa Stevens, Rachel Tanner, et al.
Abstract This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three of the unvaccinated animals w…