Showing 1–25 of 200 documents
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Jie Tan, Jun Huang, Jin Wang
…dy aimed to evaluate the efficacy of bedaquiline-containing regimens versus conventional regimens for cavitary MDR-PTB based on CT imaging. This retrospective study included 100 patients with cavitary MDR-PTB treated from June 2023 to June 2025. Patients were divided into a Conve…
Seyed Saeed Hashemi Nazari, Saeid Fallah, Vahideh Raeisi
Context The number of tuberculosis (TB) patients and multidrug-resistant species of Mycobacterium tuberculosis are increasing worldwide. Effective treatment is still the key factor to control TB in the society. Aims The aim of the study was to compare the efficacy of fixed-dose c…
World Health Organization
Courtney M. Yuen, Moorine Sekadde, Brian Kaiser, Brenda Waning, Stephen M. Graham
…for TB disease or infection, the length of common treatment regimens poses a challenge to the implementation of child-friendly TB care. Undergoing TB disease treatment, which previously ranged from 6 months for drug-sensitive TB to up to 2 years for multidrug-resistant TB (MDR-TB…
Sarah Meredith, MD, Andrew Nunn, PhD
… the rise, there is a need to investigate optimal treatment regimens using effective drugs. The STREAM study is an international, multi-centre, parallel-group, open-label, randomised, controlled trial in patients with multi-drug resistant tuberculosis (MDR-TB) including patients…
Sedona Sweeny
…iming to assess the costs to patients and providers of such regimens and to estimate the cost-effectiveness and poverty impact of an introduction of new MDR-TB regimens in the three countries participating in the main study. Multidrug resistant tuberculosis (MDR TB), tuberculosi…
Kwonjune J. Seung, Cathy Hewison
…rug-resistant tuberculosis to more effective and safer drug regimens that avoid debilitating side-effects, such as permanent hearing loss.2Farmer PE Better and safer treatment for multidrug-resistant tuberculosis.Lancet. 2018; 392: 798-800Summary Full Text Full Text PDF PubMed Sc…
N.А. Lytvynenko, Y. I. Feschenko, Maryna Pogrebna, A.S. Lapheta, L.V. Shcherbakova, et al.
…iveness of various shortened standard or modified treatment regimens for patients with multidrugresistant tuberculosis. Materials and methods. A prospective observational study was carried out to study different shortened AMBT regimens for 346 patients with multidrug-resistant t…
Tari Nur Fauziyantini, Umi Yuniarni, Lanny Mulqie
…since 2023, Indonesia has implemented several TB-RO therapy regimens, namely BPaLM (6 months), BPaL (6 months), 9 month regimen, and long-term regimen (18-24 months). The choice of regimen is based on the patient's condition, treatment history, and level of resistance to certain …
Innocent Murhula Kashongwe, Leopoldine Mbulula, Fina Mawete, Nicole Anshambi, Nadine Maingowa, et al.
…w approach improved favorable outcomes. Both short and long regimens reached a high level of favorable outcome compared to the previous study. The short regimen, well supervised seems to be superior to the long regimen in term of Death rate and loss to follow up (LTFU).
R. Swapna, Karanth M P Swathi, M. Somashekar, Asit Kumar Chakraborty, J.S. Akshata, et al.
…entional longer regimen. Evaluating the performance of both regimens in a programmatic setting will help in tailoring the treatment regimen of MDR-TB. Objectives: To estimate the duration of sputum smear conversion in the shorter MDR-TB regimen. 2. To compare the treatment outcom…
Taipei Medical University WanFang Hospital
… (Ri-TB) and TB patients for whom rifamycin-sparing anti-TB regimens are preferred due to drug-drug interaction (Rs-TB). Trial intervention The novel regimen will be given in two phases: 1. An intensive phase consisting of isoniazid, bedaquiline, moxifloxacin and pyrazinamide …
Wenhong Zhang, PhD
The purpose of this study is to assess the efficacy, safety and tolerability of a combination of levofloxacin, linezolid, cycloserine and pyrazinamide (or clofazimine if resistant to pyrazinamide) treatments for 24 to 32 weeks (regimen consisted of clofazimine for 36\~44 weeks) i…
Raehan Satya Deanasa, Arya Marganda Simanjuntak, Fara Syafira, Putri Mahirah Afladhanti, Anisa Hawari, et al.
… and moxifloxacin was active in ABSTRACT INTRODUCTION Newer regimens are needed and expected to have a shorter therapeutic time to increase drug adherence to completion in drug sensitive tuberculosis (DS-TB) patients.METHODS We conducted first a systematic review and meta-analysi…
Suman Saurabh, Pankaj Bhardwaj
…ed as a key drug with its inclusion in all the standardized regimens for drug-resistant tuberculosis. Therefore, it is important to prevent the emergence of resistance to bedaquiline. Active drug safety monitoring (aDSM) should be rigorously implemented in addition to ensuring co…
Xueyi Chen, Oscar J Nino-Meza, Mona O. Sarhan, Bhavatharini Arun, Byeonghoon Jeon, et al.
…dicted tissue exposures which were used to design optimized regimens (Fig.1).Figure 1.Study design. Dynamic positron emission tomography (PET) was performed using radioanalogs of antibiotics (18F-pretomanid, 18F-sutezolid, 18F-linezolid and 76Br-bedaquiline) active against MDR st…
Heping Xiao, M.D
Multi-center, prospective study is performed to investigate the efficacy of new short-course regimen for retreatment pulmonary tuberculosis patients. To obtain optimized short-course regimen, decrease treatment cost and improve success rate. China is the country with the second…
Zarir Udwadia, Jennifer Furin
…n it comes to rolling out bedaquiline (BDQ)-based, all-oral regimens for drug-resistant forms of tuberculosis (DR-TB). India is home to the largest population of people living with DR-TB in the world,[2] and improving access to innovative diagnostic and therapeutic approaches is …
Е. А. Бородулина, М.В. Ураксина, E. P. Еremenko, T. M. Larionova, A. N. Gerasimov
…tment method seems relevant. Aim: To analyze the prescribed regimens and the reason for their correction in newly identified patients before verifying the diagnosis of tuberculosis. Material and Methods. The following methods were used to detect MBT: luminescent microscopy, molec…
Bern-Thomas Nyang'wa, MD
… controlled, phase II-III trial; evaluating short treatment regimens containing bedaquiline and pretomanid in combination with existing and re-purposed anti-TB drugs for the treatment of biologically confirmed pulmonary multi drug-resistant TB (MDR-TB). This is a multi-centre, o…
Ajay Gupta
…torically required long, toxic, and operationally demanding regimens–often extending beyond 18 months and associated with treatment fatigue, high default rates, and severe adverse effects. Against this background, the World Health Organization recommended the all-oral, 6-month BP…
Rivaldo Heru Setiawan
…) contributing substantially to poor outcomes. Conventional regimens span 18–24 months, leading to limited adherence and treatment success. Shorter treatment regimens (STRs), such as the BPaL regimen (bedaquiline, pretomanid, and linezolid), have emerged as promising alternatives…
Preethi Koyyana, Mohana Pradeepika Machcha, Rajasekharam Gunta, Dhilleswara Rao Pudi
… reduction of social stigmatization. In contrast to earlier regimens that contained injectable drugs, the World Health Organization has recommended all-oral regimens for the treatment of Multidrug-Resistant/Rifampicin-Resistant-TB since 2018, which represents a significant advanc…
Muhammad Rifqy Alvy Widodo, Ida Srisurani Wiji Astuti, Inke Kusumastuti, Angga Mardro Raharjo, Supangat Supangat, et al.
… comparison between the administration of individual MDR-TB regimens and short-term regimens concerning anxiety levels in MDR-TB patients at Dr. Soebandi Regional General Hospital, Jember. Methods: This was an analytical observational study with a cross-sectional design. It was c…
Jyoti Bajpai, Darshan Kumar Bajaj, Sandeep Kumar, Rashmi Kushwaha, Surya Kant, et al.
…fication test)&LPA(Line Probe Assay)and availability of regimens with duration of 9-11months in contrast to previous lengthy regimens things have become better. Present study was undertaken to study microbiological conversion and adverse effect profile of shorter regimen <b>M…