Showing 1–25 of 115 documents
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Inna Friesen, Timo Ulrichs, L. A. Hryshchuk, H. S. Saturska
Objective — to compare the epidemiological situation of chemoresistant tuberculosis in Germany and Ukraine, in addition analyzing the nature and features of chemoresistant tuberculosis in 192 patients treated at the Ternopil Regional TB Dispensary Ukraine during 2017—2018.
 …
Sora Yasri, Viroj Wiwanitkit
… of extensively drug-resistant M. tuberculosis. The genetic epidemiology study on the extensively drug-resistant M. tuberculosis isolate can provide helpful data for local public health planning. Here, the authors reappraise on the available data[34] on molecular epidemiology of …
Olha Konstantynovska, Oleksandr Liashenko, Petro Poteiko, Anton Rohozhyn, Ivan Hrek, et al.
Ukraine ranks fourth globally with the highest number of MDR (multiple drug resistant) and XDR (extensively drug resistant) TB cases in the world. Recent study showed M. tuberculosis isolates were as high as 35% XDR in Ukraine, and the most common strains among the XDR-TB are due…
Mandlenkosi Manika, Lindiwe Modest Faye, Ntandazo Dlatu, Mojisola Clara Hosu
…ssion of resistance-associated genetic mutations. Molecular epidemiology provides critical insights into mutation profiles and resistance associations, yet the interplay among key mutations and their contributions to complex resistance patterns remains poorly understood, particul…
M. Kumar, Sonam Sharma
…ering aspects such as transmission, pathogenesis, worldwide epidemiology, diagnostic methods, treatment protocols, drug resistance, preventive measures, and current research endeavours. Focus is directed towards innovative molecular diagnostics, the incorporation of artificial in…
Kamonnut Singkhamanan
Pseudomonas aeruginosa (n = 112) isolates from various clinical specimens of hospitalized patients in Songklanagarind Hospital, southern Thailand from February 2012 to January 2013 were analyzed for susceptibility to 10 different antibiotics using a disk diffusion method and gene…
Kumari Neelam, Ira Sharma, Devinder Kumar, Kunal Goel, Virender Singh, et al.
…ummarizes the latest developments in the field, focusing on epidemiology, pathogenesis, diagnostic innovations, novel anti-tuberculosis drugs, combination therapy approaches, surgical interventions, adjunctive therapies, and the importance of multidisciplinary approaches. Emergin…
Fariza Fadzil, S R Ramli, Hui‐min Neoh
…s the timeline of pulmonary tuberculosis (PTB) in Malaysia, epidemiology, management and outlook of the disease in the country. PTB was first reported in Malaya in the early 20th century and caused high morbidity and mortality. With the establishment of the National TB Control Pr…
Neelima Sharma, Arjun Khanna, Shivani Chandra, Saurav Basu, Kanwaljit Chopra, et al.
Background: Multidrug-resistant tuberculosis (MDR-TB) referring to tuberculosis that is resistant to both rifampicin and isoniazid is a major challenge against meeting TB elimination targets. We conducted this operational research study with the objective of describing MDR-TB tre…
Sonia Islam Khan
… narrative review explores the current understanding of the epidemiology, clinical features, diagnostic approaches, and challenges related to treatment failure in TB. Globally, an estimated 10 million new TB cases and 1.3 million TB-related deaths were reported in 2022, with the …
T. D. (Tosheva) Rakhmatovna
Extensively drug-resistant tuberculosis (XDR-TB) represents a serious threat to global public health, especially in resource-limited countries. This paper reviews current data on the prevalence, mechanisms of resistance, and clinical-epidemiological features of XDR-TB, as well as…
Medina
With 5,000 new active cases each year, tuberculosis in Chile remains as the most important communicable disease in the country. Since the type of control programs are linked to the epidemiologic situation as far as infection, morbidity and mortality are concerned, an effective su…
Gizachew Taddesse Akalu, Belay Tessema, Waganeh Sinshaw, Misikir Amare, Getu Diriba, et al.
Abstract Background Conventional wisdom wrongly holds that the microbiological of M. tuberculosis complex in clinical specimens via culture and phenotypic drug susceptibility testing allows people to be correctly diagnosed and ensures an effective treatment regimen to be selected…
Thinley Dorji
Introduction: Multidrug resistant tuberculosis (MDR-TB) is defined as a case of tuberculosis resistant to rifampicin and isoniazid which are the first line anti tuberculosis drugs. Globally emergences of MDR-TB possess a challenge to TB control. In Bhutan, the proportion of MDR-T…
A. S. (Abdullaeva) Sh
A third of the world's population is infected with Mycobacterium tuberculosis (MTB) and more than 9 million cases of tuberculosis (TB) are diagnosed annually, resulting in almost 2 million deaths each year (WHO., 2015). TB accounts for more than a quarter of all preventable death…
Azfar A. Ishaqui, Salman A. Ahmad, Shoaib Alam, Narendar Kumar, Javeria Farooq, et al.
Objectives: Tuberculosis (TB) continues to drive infectious mortality worldwide. The study characterized the evolution of drug-susceptible TB (DS-TB), multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB) in 30 WHO high-burden countries, linking current patt…
Safaa Alkhawaja
Introduction: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide, drug resistance is one of the major contributors to that. No existing published data about the burden of Multi-Drug Resistant (MDR) TB in the kingdom of Bahrain, the aim of our study is to…
Olivera Bojovic, D. Gudelj, S. Lucic, Božidarka Rakočević
Background: In the conditions of declining rate of drug-resistant tuberculosis and high success rate of treatment of these cases, occurrence of MDR/XDR-TB due to complexity of its treatment remains the main problem in controlling this disease in Montenegro. Methods and materials:…
О. А. Пасечник, В. Л. Стасенко
The results of modeling the further development of the epidemic process of tuberculosis in several regions of the world, including the Russian Federation, indicate an unfavorable prognosis in the spread of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculo…
Nigussie Assefa Kassaw, Jemal Haidar, Dawit Getachew Assefa, Daniel Fiseha, Dereje Habte, et al.
Ethiopia is among the thirty-high tuberculosis (TB) burden countries with multidrug resistant tuberculosis (MDR-TB) and Tuberculosis/Human Immunodeficiency Virus (TB/HIV). Given the public health importance of the problem, it is apparent that probing the work done in this regard …
Luísa Heinzen Cescon, Ana Júlia Probst Nichellatti
Drug-resistant tuberculosis represents one of the main challenges for disease control in Brazil. Cases of multidrug-resistant tuberculosis (TB-MDR) and extensively drug-resistant tuberculosis (TB-XDR) increase treatment duration, costs, and the risk of unfavorable outcomes. This …
Suphanat Wongsanuphat, Charuttaporn Jitpeera, Orathai Suwanchairob, Wannisa Theprongthong, Patcharin Tantiworrawit, et al.
On 31 May 2019, the Division of Epidemiology (DoE) was notified of a confirmed extensively drug-resistant tuberculosis (XDR-TB) case in Bangkok. The DoE and local teams conducted a joint investigation to describe the epidemiological characteristics of the case, identify possible …
Dong Jin Joo
We argue in favor of a concerted and coordinated response to stop tuberculosis (TB) by monitoring global TB spread, drug-resistance surveillance and populations at risk using available molecular and web tools to identify circulating clones of Mycobacterium tuberculosis complex (M…
N.A. Pavluchenkova, A.V. Mikheeva, E. A. Sakharitova
The spread of multidrug-resistant and extensively drug-resistant tuberculosis (MDR and XDR) requires the search and implementation of not only new diagnostic methods, but also innovations in the treatment of the disease. Aim. The assessment of current treatment options for multid…
Yue Wang, Weibing Wang
Given that existing tuberculosis interventions and strategies are not going to enable achievement of WHO's goal to eliminate tuberculosis by 2050,1Xu K Ding C Mangan CJ et al.Tuberculosis in China: A longitudinal predictive model of the general population and recommendations for …