Showing 1–8 of 8 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Wenping Gong, Jianping Xie, Hao Li, Ashok Aspatwar
…/tuberculosis). However, it is reported that the protective efficacy of BCG is highly variable and ranges between 0% and 80%, and its protection lasts only for 10 to 15 years [2]. Therefore, developing a new effective TB vaccine is pressing and challenging for governments and sci…
Wenping Gong, Ashok Aspatwar, Jianping Xie, Hao Li
…24, demands urgent innovation [1]. The limited and variable efficacy (0-80%) of the Bacille Calmette-Guérin (BCG) vaccine in adults, a challenge starkly highlighted during the COVID-19 pandemic, underscores the critical need for novel prophylactic and therapeutic strategies [2][3…
Julio HR Croda, PhD
…ncarceration (on average 3 years), primary prophylaxis with BCG revaccination may be a cost-effective alternative associated with mass screening for control of the disease. Recently, in a phase 2 clinical trial, the BCG vaccine was shown to be 45% effective in preventing sustaine…
Mohamed E. El Zowalaty, Hossam M. Ashour
…emely drug-resistant Mtb. In addition, the only approved TB vaccine is the current vaccine Bacille Calmette-Guérin (BCG), which provides partial and variable protection. Currently, there are at least 16 candidate vaccines in various stages of clinical development in the global TB…
Xiaofang Zhao, Caihong Guo, Lianwen Wang, Zhijun Liu
…merge in the absence of systematic interventions. While the BCG vaccine provides substantial protection against infantile TB, its efficacy against pulmonary TB in adults varies significantly. Currently, six candidate vaccines aimed at preventing or delaying the progression from L…
Jann-Yuan Wang, Ph.D.
… investigators designed this prospective study to follow up adult household contacts with LTBI for 2 years and compare the efficacy of 9-month isoniazid and 4-month rifampicin). In countries with a low incidence of tuberculosis (TB), most new, active cases have occurred among pe…
Jay A. Fishman
… clinical practice guidelines: diagnosis of tuberculosis in adults and children.Clin Infect Dis. 2017; 64: 111-115Crossref PubMed Scopus (390) Google Scholar, 3Aguado JM Torre-Cisneros J Fortun J et al.Tuberculosis in solid-organ transplant recipients: consensus statement of the …
Queen Mary University of London
…lood mononuclear cells (PBMC) isolated from * asymptomatic adults being screened for LTBI (LTBI screenees) * adults with newly-diagnosed active tuberculosis (active cases) ii) To determine whether strains of Mtb isolated from CD34+ PBMC of recent household TB contacts are geneti…