Showing 1–12 of 12 documents
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Mark F. Cotton, Helena Rabie
… control through vaccination remains a global priority. The efficacy of BCG given to neonates to prevent tuberculosis meningitis and miliary tuberculosis is well known.1Trunz BB Fine P Dye C Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis wo…
Eloise T. M. Filardi, Roberto Carlos Cruz Carbonell, Fernando R. Pavan, Felipe A. Cerni, Manuela B. Pucca
Vaccines represent one of the most significant achievements in medical science, constituting safe preparations or substances developed with the primary purpose of stimulating the immune system (1,2). Their central function is to protect the human body against a myriad of infectio…
Helen McShane, Dr
…erially naïve individuals, those previously vaccinated with BCG and latently infected individuals. Additionally, 5 x 10\^7 pfu MVA containing HIV antigens administered twice, 4 weeks apart, in HIV positive individuals, is safe. We will use 5 x 107 pfu MVA85A intradermally in this…
Helen McShane
…ally naïve individuals and those previously vaccinated with BCG. We will use the same vaccination regime in this study. Subjects will be defined as being latently infected if they have a positive elispot response to ESAT6 or CFP10. Subjects will be identified from TB contact clin…
Mark Hatherill, MD, FCPaed
Rationale: The Bacille Calmette-Guérin (BCG) vaccine protects children against disseminated tuberculosis (TB) including TB meningitis and miliary TB, but efficacy against pulmonary TB is inconsistent among children and adults. Administration of live attenuated BCG to infants know…
Usama Sajjad, Khalid Khan Niazi, Gillian Beamer, Metin N. Gürcan
…over 2 billion individuals worldwide. Although the approved vaccine against TB, <i>M. bovis</i> Bacille Calmette-Guerin (BCG), successfully prevents TB meningitis and systemic TB in children, efficacy against pulmonary TB in adults is highly variable, ranging from 0% to 80…
Thomas E. Tavolara, Muhammad Khan Niazi, Gillian Beamer, Metin N. Gürcan
…utcomes, vaccination with M. bovis Bacille Calmette-Guerin (BCG) vaccine is used globally in children to prevent systemic disease and tuberculous meningitis. However, in adults, epidemiological studies show variable protection ranging from 0% to 80%. As a part of a larger study t…
Stephen Gordon, MD
Despite tremendous efforts, an effective tuberculosis (TB) vaccine remains elusive. TB continues to infect and kill many. In 2021, TB infected more than 10 million and killed 1.6 million people. To date, the M.bovis bacille Calmette Guerin (BCG) is the only licensed vaccine again…
Beatrice Napoli
…days, it comprises the use of the Bacillus Calmette-Guérin (BCG) vaccine, developed one century ago but still the first-line weapon against TB. Despite evident challenges, that include variability in efficacy, vaccination with BCG has been proven to significantly reduce the incid…
Videlis Nduba
BCG, the only licensed vaccine against tuberculosis in use today, protects against severe extrapulmonary forms of TB in humans (miliary and meningeal forms), but offers variable protection against the most common respiratory form of the disease (pulmonary TB), with ranges of effi…
Dženan Kovačić, Adna Softić, Adna SALIHOVIĆ, Jovana Jotanović, Sarah Maris Hotić
…numerous reasons for such statistics is the relatively poor efficacy of the near-century-old BCG vaccine. In spite of it being the only approved vaccine for TB, its benefit is predominantly observed in preventing paediatric miliary TB and TB meningitis, whilst it offers considera…
Rafael Laniado-Laborín
…s, the clinical manifestations are very similar to those of adults with fever and productive cough. Lymphadenopathy is the most common type of extrapulmonary TB in children. The most commonly involved sites are the anterior cervical, posterior cervical triangle, submandibular, an…