Showing 176–200 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Shyam Sundar Meena, Pritesh Goutam, Meena LS
…them. Adjuvants are the one such factor that can be used in vaccines to crack such problems. Many vaccines are under clinical trials in which subunit vaccine has taken attention because they are safer and can be standardized. There are many adjuvants which have been tested in com…
Tanzeela Sameen Saeed, Maythem Saeed, Muhammad Fahad Abdullah, M. N. Qureshi, Armeen Saeed
…pulmonary TB, prompting the need for novel strategies. mRNA vaccines, successful in the fight against COVID-19, are now being explored for TB prevention. Methods We conducted a comprehensive narrative review of the current state of mRNA vaccine development for TB. Literature was …
Eziamaka J. Enemuo, Kenechukwu K. Iloh, Agozie C. Ubesie, Henrietta U. Okafor, Anthony Nnaemeka Ikefuna
Background: Although Bacillus Calmette Guerin (BCG) vaccine remains one of the most important public health preventive measures against tuberculosis (TB), the presence of a BCG scar may not imply an immune response. Tuberculin reactivity after BCG vaccination has been the most co…
Masoud Keikha, Majid Eslami, Bahman Yousefi, Mohsen Karbalaei
…lts to latent forms of disease. Among the new generation of vaccines, fusion multistage subunit vaccines have prodigious effect on immune responses. By virtue of simultaneous presence of both expressed antigens from active and latent forms of TB in the structure of these recombin…
Muhammad Irfan, Syed Usama Masood, Talha Laique
Background: BCG is a vaccine obtained by attenuating Mycobacterium bovis. It is a fairly safe vaccine with no associated complications. Aim: To determine the frequency of accelerated BCG response in BCG vaccinated children. Study design: Descriptive case series. Methodology: A to…
O. A. Kuznetsova, А. А. Голубкова, Н. В. Башмакова
Relevance . In perinatal centres problems of timely vaccination of newborns arise more often than in maternity hospitals, as vaccinations against viral hepatitis B and tuberculosis in accordance with the National Calendar are carried out in an early neonatal period and in time co…
Julia M. Scordo, Tucker J. Piergallini, Colwyn A. Headley, Vida Hodara, Nicole Reuter, et al.
…ons account for one-third of deaths in elderly individuals. Vaccines are a primary tool to combat infection, yet they are less effective in the elderly population. While many groups have aimed to address this problem by studying vaccine-induced peripheral blood responses in the e…
Carlos Eduardo Duarte, Guilherme Gaeski Passuello, Raquel Neves, Fernanda Cappi Santos Duarte
Introduction: BCG vaccine (bacillus Calmette–Guérin) has been developed against tuberculosis and proven to be used for other purposes by activating and/or training innate immunity. The protective effect against the new coronavirus should be investigated and tested while a specifi…
Mina Kelleni
Multiple reports all over the world are hypothesizing a possible relationship between BCG vaccination, and a lesser incidence of and mortality from COVID-191. China is considered as one of the heavily affected countries and it was the first to report COVID-19, the author will exa…
R. M. Mariita, Jonathan M. Musila
The Covid-19 pandemic, which originated from Wuhan, Hubei province, China, and quickly spread to the rest of the globe is caused by SARS-CoV-2 coronavirus. Preliminary data suggest a relationship between the BCG vaccine and the prevalence of Covid-19. The vaccine is used in the p…
Puck T. Pelzer, Logan Stuck, Leonardo Martínez, Alexandra S Richards, Carlos Acuña-Villaorduña, et al.
BACKGROUND: Tuberculosis vaccine trials using disease as the primary endpoint are large, time consuming, and expensive. An earlier immunological measure of the protection against disease would accelerate tuberculosis vaccine development. We aimed to assess whether the effectivene…
Ann Barber, M.C.M. de Jong
In the Republic of Ireland (RoI), bovine Tuberculosis (bTB) in cattle continues to circulate despite considerable efforts placed on controlling the infection. The European badger (Meles meles) is considered by most scientist to be implicit in the transmission and maintenance of b…
Hua Wang
…sy patients. The history and latest developments in leprosy vaccines are explored in this chapter.
Vincenzo Patella, Alessandro Sanduzzi, Dario Bruzzese, Giovanni Florio, Raffaele Brancaccio, et al.
Background: Epidemiological studies show that BCG-vaccinated population seems to be more likely protected from COVID-19 infection, but WHO gave a stark warning on use of BCG vaccine without confirmed COVID-19 trials. The aim of the study is to evaluate whether TB vaccination, per…
Rebecca A. Clark, Christinah Mukandavire, Allison Portnoy, Chathika K. Weerasuriya, Arminder Deol, et al.
…sis is a leading infectious cause of death worldwide. Novel vaccines will be required to reach global targets and reverse setbacks from the COVID-19 pandemic. We estimated the impact of novel tuberculosis vaccines in low- and middle-income countries (LMICs) under alternative deli…
Abhishek Mishra, Wen-Chien Wang, Varsha Rawat, Ekramy E. Sayedahmed, Suresh K. Mittal, et al.
…e has a partial efficacy against tuberculosis, many booster vaccines have been investigated to improve its efficacy. We developed novel, replication deficient bovine adenovirus (BAdv)- based TB vaccines that encode secreted mycobacterial Ag85B, ESAT6 and CFP10. Because a first ge…
A. O. Egonmwan, D. Okuonghae
Since 1921, the Bacille Calmette–Guerin (BCG) vaccine continues to be the most widely used vaccine for the prevention of Tuberculosis (TB). However, the immunity induced by BCG wanes out after some time making the vaccinated individual susceptible to TB infection. In this work, w…
Waqo Boru, George Makalliwa, Caroline Patricia Musita
Although vaccination is a cost-effective, equitable, and impactful public health intervention in curbing the spread of infectious disease, low uptake is a significant concern, especially among high-risk population groups. Nearly half of the population is unvaccinated in Nairobi, …
Elena Plamenova Stefanova, Eva Sierra, Antonio Fernández, Óscar Quesada‐Canales, Yania Paz-Sánchez, et al.
(MAP), were collected at slaughter from a farm with a confirmed history of paratuberculosis (PTB). These goats had subclinical infections. PTB-compatible lesions in the MS LNs, ICV lamina propria (LP), and Peyer's patches (PPs) were graded separately. Furthermore, the load of aci…
Ehsan Rashidian, Ali Forouharmehr, Amin Jaydari
Background: Tuberculosis is known as one of the most dangerous diseases caused by Mycobacterium tuberculosis. Although different strategies have been applied to prevent this disease, it is still considered a killer disease in the world. Objectives: This project was conducted to d…
Zhaolin Huang
…afety and immunogenicity of low-dose adjuvants and low-dose vaccines in the upper arm deltoid muscle intramuscularly in the double negative population. Thirty (PPD-QFT-) healthy adult subjects aged 18-45 were selected and divided into placebo group, low-dose adjuvant group, and l…
Vitaly V. Ganusov, Dipanjan Chakraborty
…ach can be used to rigorously quantify efficacy of other TB vaccines in ULD-infected mice. Funding Sources NIH/NIAID R01AI158963 Topic Categories Vaccines and Immunotherapy (VAC)
Divya Goswami, Gautam Kalwadia, Kunal Saini, Anita Sondhi
… of TB, necessitating the importance of better and improved vaccines. The emergence of drug-resistant TB, like MDR-TB (multidrug-resistant TB and XDR-TB (extensively drug-resistant TB, has made the situation even more serious. Nearly nineteen new TB vaccines are in clinical trial…
Helly Mayankkumar Joshi, Yugam Rajeshkumar Oza, Meirajuddin J. Tousif, Anjali Srikanth Mannava, Jash K. Shah, et al.
This systematic review critically investigates the administration of the Bacillus Calmette-Guérin (BCG) vaccine in neonates with severe combined immunodeficiency (SCID). The BCG vaccine, derived from Mycobacterium bovis, is a live attenuated vaccine recognized for its significant…
Monique Ribeiro de Lima, André Cesar Leandro, Andreia Lamoglia Souza, Márcio Mantuano Barradas, Eric Henrique Roma, et al.
…sis infection in adulthood. New advances in delivery of DNA vaccines by electroporation have been made in the past decade. We evaluated the safety and immunogenicity of DNA-hsp65 vaccine administered by intramuscular electroporation (EP) in cynomolgus macaques. Animals received t…