Showing 176–200 of 200 documents
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Kaisheng Su, Ximeng Li, Zhenyu Jiang, Yifang Mei
…y, and additionally come with a substantial cost-burden for healthcare systems largely due to additional treatment and hospitalization needs. Furthermore, the treatment of RDs may also need to be put on hold when TB infections occur.7 Under such conditions, preventing LTBI reacti…
Tuberculosis (TB) is a worldwide health, economic, and social burden, especially in developing countries.Drug-resistant TB (DR-TB) is the most serious type of this burden.Thus, it is necessary to screen drug-resistant mutations by using a simple and rapid detection method.A total…
Shafi Ullah Zahid, Ahmad Khan, Hasibullah Aminpoor, Mohammad Jaweed
…ficits including paraplegia or even quadriplegia, with huge health, economic and psychological burden. We are reporting a case of Pott’s disease involving the cervical spine (C5/C6) in a 50-year-old man who presented with unusually quadriparesis and severe neck tenderness on touc…
Gavin Churchyard, PhD, MD, Annelies Van Rie, PhD, MD, Rob M Warren, PhD, Salome Charalambous, PhD
…sed with RR-TB. We will additionally perform an exploratory health economics evaluation of both arms, and will determine the feasibility of the WGS DST strategy. The trial will be a single blinded randomised controlled, pragmatic, medical device trial evaluating a Whole Genome S…
Mareli Claassens, PhD
…amme will be used to develop the model which will include a health economics component. The study will strengthen DR-TB diagnosis, surveillance and control, inform DR-TB case finding policy in Namibia and regionally, inform resource allocation by identifying high transmission ar…
Pengpeng Yang, Yuzhu Song, Xueshan Xia, A‐Mei Zhang, Afanas'ev, et al.
Tuberculosis (TB) is a worldwide health, economic, and social burden, especially in developing countries.Drug-resistant TB (DR-TB) is the most serious type of this burden.Thus, it is necessary to screen drug-resistant mutations by using a simple and rapid detection method.A total…
Olivier Marcy, MD, PhD, Maryline Bonnet, MD, PhD, Eric Wobudeya, MD, PhD
…nia later being diagnosed as TB. However, the current World Health Organization (WHO) standard of care (SOC) for young children with pneumonia considers a diagnosis of TB only if the child has a history of prolonged symptoms or fails to respond to antibiotic treatments. Hence, TB…
Tiffeney Mann, Rishi K Gupta, Byron W P Reeve, Gcobisa Ndlangalavu, Aneesh Chandran, et al.
…led consecutive adults referred to start ART at a community health centre in Cape Town, South Africa, irrespective of symptoms. Sputa were obtained (using induction if required) for two liquid cultures. Whole-blood RNA samples underwent transcriptional profiling using a custom Na…
Fleur ter Ellen, Kaat Tielens, Christine Fenenga, Liesbeth Mieras, Anne Schoenmakers, et al.
…reduce the transmission of Mycobacterium leprae , the World Health Organization recommends single-dose rifampicin (SDR) as post-exposure prophylaxis (PEP) for contacts of leprosy patients. Various approaches to administer SDR-PEP have been piloted. However, requirements and crite…
Alice Halliday, Pooja Jain, Long Hoàng, Robert Parker, Mica Tolosa-Wright, et al.
…ures, measured each of the new technologies and performed a health economic analysis in which the best-performing tests were evaluated for cost-effectiveness. The diagnostic accuracy of the transcriptomic tests ranged from an AUC of 0.81 to 0.84 for detecting all TB in our cohort…
Evita Puspita Sari, Neily Zakiyah, Prayudi Santoso, Melisa Intan Barliana
…rug Resistant Tuberculosis (MDR-TB) remains a burden on the healthcare system and public health. Evidence on cost and cost-effectiveness of MDR-TB treatment option is necessary in order to provide evidence-based recommendation for policymakers. The main therapy for MDR-TB consist…
Charl Bezuidenhout, Lawrence Long, Brooke E Nichols, Gesine Meyer‐Rath, Matthew P. Fox, et al.
…m all household contacts of confirmed tuberculosis cases. A health economic assessment was executed to estimate and compare the cost and cost-effectiveness of different in-home, point-of-care testing strategies. Incremental cost effectiveness ratios of strategies utilizing differ…
Emecheta G. Okwudire, Ugonna M. Ezenwugo, Johnpatrick U. Ugwoegbu, Chika A. Okoro, Ifeanyichukwu Isiozor
…ficits including paraplegia or even quadriplegia, with huge health, economic and psychological burden. Following is a case report of Pott’s disease involving the cervical spine in a 33-year old farmer presenting unusually with paraplegia and a negative Mantoux test. It is reporte…
Simon C. Mendelsohn, Stanley Kimbung Mbandi, Mark Hatherill, Thomas J. Scriba
…assessment of prospective diagnostic accuracy in real-world health-care settings. In The Lancet Respiratory Medicine, Carolin Turner and colleagues4Turner CT Gupta RK Tsaliki E et al.Blood transcriptional biomarkers for active pulmonary tuberculosis in a high-burden setting: a pr…
M Park, Giovanni Satta, Joan Nanan, B Tomas-Cordero, Meg Coleman, et al.
…ficant lead time advantage to culture. The data argue for a health-economic analysis to determine its value as a first-line test that replaces smear in people with possible mediastinal nodal TB.
MÁ García Bereguiain
Tuberculosis (TB) is a worldwide health, economic, and social burden, especially in developing countries.Drug-resistant TB (DR-TB) is the most serious type of this burden.Thus, it is necessary to screen drug-resistant mutations by using a simple and rapid detection method.A total…
Cedric Kafie, Mona Salaheldin Mohamed, Miranda Zary, Chimweta Ian Chilala, Shruti Bahukudumbi, et al.
…(16 studies) and was generally cost saving when compared to healthcare provider directly observed therapy (DOT), particularly when costs to patients were included--though findings were largely from high-income countries. Cost-effectiveness findings were highly variable, ranging f…
Grant Theron, PhD
…udio analysis, use of mixed methods research - drawing from health economics, implementation science, and medical anthropology - to inform product design and assess barriers and facilitators to implementation, and uniquely for a TB diagnostic test, its potential deployment as a p…
Kin Wang To
…udies powered to show the cost effectiveness of TBST on the health economics for preventing development of TBI into active TB. Moreover, generalisation of the test results to general population is problematic as the methodologies and subjects in clinical studies are very heteroge…
Akshay Garg, Poonam Shakya, Ravindra Pal Singh, Pradeep Kumar Singh
… concern in veterinary medicine due to its impact on animal health, economic stability, and public safety. Effective diagnosis is essential for disease control, with traditional methods such as the intradermal tuberculin test serving as the gold standard. However, advancements in…
Rishi Kumar Gupta, Mahdad Noursadeghi
…n of infection. In the study published by The Lancet Global Health, Simon C Mendelsohn and colleagues2Mendelsohn SC Fiore-Gartland A Penn-Nicholson A et al.Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diag…
MÁ García Bereguiain
Tuberculosis (TB) is a worldwide health, economic, and social burden, especially in developing countries.Drug-resistant TB (DR-TB) is the most serious type of this burden.Thus, it is necessary to screen drug-resistant mutations by using a simple and rapid detection method.A total…
Adithya Cattamanchi, MD
…diagnostics development, laboratory medicine, epidemiology, health economics and mathematical modeling with highly experienced clinical study sites in 10 countries. The Rapid Research in Diagnostics Development for TB Network (R2D2 TB Network) study seeks to identify and rigorou…
James Louis–Jean, Magdonald Aime
…e a global pandemic, causing major global issues, including health, economic, and age-preference, among other issues. This text summarizes the nature of the emerging COVID-19 global pandemic while analyzing several factors concerning the etiology of the virus. This is done in an …
Kinfu Tato, Abdu Mohamed, Mukarim Abdurahaman
…ne tuberculosis poses a significant global threat to public health and economic stability, particularly in developing nations like Ethiopia, where community awareness and appropriate practices are often limited. This study aimed to assess the knowledge, attitudes, and practices o…