Showing 151–175 of 200 documents
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Veronique R de Jager, MD, Prof. Rodney Dawson, MD, Prof. Andreas Diacon
…h uncomplicated, smear-positive, drug-susceptible pulmonary tuberculosis (TB).
L.D. Todoriko, I. Margineanu, Ihor Semianiv, Fajri Gafar, Teodora Butnaru, et al.
…ctors that affect the results of treatment of patients with tuberculosis. Materials and methods. A retrospective multi-center study was conducted on adult (> 18 years) patients diagnosed with drug-sensitive susceptible TB of any form and initiated treatment between 1st of Janu…
C.-S. Yoon, T.-O. Kim, Yoonku Kwon, Jinsoo Min
…ract Rationale: The standard treatment for drug-susceptible tuberculosis (TB) typically involves six months of short-course chemotherapy. However, in real-world practice, prolonged treatment is frequently employed. This study aims to identify predictors of prolonged treatment amo…
Yoonku Kwon, C.-S. Yoon, T.-O. Kim, Jeong‐Ki Min
…ent are recognized risk factors for recurrence in pulmonary tuberculosis (TB). Consequently, extended treatment has been recommended for these patients, although objective evidence to support this practice is limited. Methods: We conducted a retrospective analysis using data from…
Ismaila L. Manneh, Fatoumatta Darboe, Haddijatou Jobe, Binta Sarr Kuyateh, Ousainou Cham, et al.
…bility of effective treatment regimens for drug-susceptible Tuberculosis (TB), some patients still experience poor treatment outcomes. Currently tools for monitoring treatment outcomes are dependent on detection of mycobacteria in sputum, which are slow, expensive and poor at pre…
O.M. Shvets, О.С. Шевченко, Hanna Stepanenko
…e development in drug-susceptible newly diagnosed pulmonary tuberculosis patients. Those patients who developed insulin resistance during the 30 days of antitubercular therapy have expressed metabolic changes, that may be associated with impaired liver function due to the toxic e…
Yu.O. Matviienko, О. M. Rekalova, V.М. Zhadan, S.H. Yasyr, А.В. Тараненко, et al.
…s of integral hematological indices (IHI) in drug-sensitive tuberculosis (DSTB) after a previous coronavirus disease (COVID-19) under the influence of chronic stress caused by martial law. MATERIALS AND METHODS. A retrospective analysis of the results of the examination of 66 pat…
Greta Musteikienė, Skaidrius Miliauskas, Jurgita Zaveckienė, Daiva Urbonienė, Astra Vitkauskienė, et al.
<b>Introduction:</b> Tuberculosis (TB) biomarker discovery could aid the routine clinical practice and in shortening of clinical trials of new anti-TB drugs. <b>Aims and Objectives:</b> To evaluate the changes of selected host biomarkers (soluble intercellular adhesion molecule t…
S. Richardson, Pamela Vorster, Ronelle Burger, Matthias Rieger
<sec> <title>BACKGROUND</title> Tuberculosis (TB) is the leading cause of death in South Africa. Drug susceptible (DS) TB is effectively treated with a 6-month regimen, but inadequate medication adherence remains an important impediment to containing the spread of the disease and…
Jinsoo Min, Chaeuk Chung, Sung Soo Jung, Hye Kyeong Park, Sung-Soon Lee, et al.
<b>Introduction:</b> Subclinical tuberculosis (TB) disease is a potential target for public health intervention, because its early identification might reduce TB transmission. We described clinical and laboratory findings and treatment outcomes of subclinical TB disease among pat…
М.І. Lynnyk, V. І. Іgnatieva, Г. Л. Гуменюк, V.А. Svyatnenko, V.Ye. Ivashchenko, et al.
…stilities in Ukraine, led to a decrease in the detection of tuberculosis (TB) patients and an increase in mortality from this disease. Particular attention needs to be paid to the peculiarities of the course of pulmonary TB against the background of a coronavirus infection, which…
Abdulrhman Awadh Alharbi, Ibrahim Muhammad Al-Arej, Abdullatif Suliman Alsayegh, Meshal Ibrahim Zaid Al Owias, Bader Sayah Alanezi
Background: Tuberculosis (TB) is a highly infectious disease with a long history of impacting global health. Despite the availability of effective treatments, TB remains a significant cause of morbidity and mortality, particularly in low- and middle-income countries and among HIV…
Susanna S van Wyk, Marriott Nliwasa, James A. Seddon, Graeme Hoddinott, Lario Viljoen, et al.
ABSTRACT Background Transmission of drug-resistant tuberculosis (TB) is ongoing, and many households face catastrophic costs when a member is diagnosed and treated for drug-resistant TB. Finding individuals with drug-resistant TB and initiating treatment as early as possible is i…
Genevieve Dupuis, Mariia Dolynska, Silvia S. Chiang, C. Robert Horsburgh, Helen R. Stagg, et al.
Tuberculosis (TB) treatment is lengthy and causes side-effects, making treatment completion challenging. Some patients are “lost to follow-up” (LTFU) before completing treatment. Patients sometimes subsequently return to care if symptoms motivate them, or if health systems and/or…
Andrew D. Kerkhoff, Jason Zucker, Diane V. Havlir
Several novel antituberculosis agents, including long-acting injectable agents in mouse models, have shown promise in preclinical and early clinical studies. This encouraging news is offset by the failures of a tuberculosis (TB) vaccine to prevent disease recurrence and a 3-month…
Hamu J. Mlyuka, Alponce Liyoyo, Hadija Semvua, Raphael Zozimus Sangeda, Stellah Mpagama, et al.
<h3>Background</h3> High burden of Tuberculosis (TB) in Africa justify continued need for development of safe, efficacious, accessible and affordable anti-TB. Paradoxically, the continent contributes <3% of global clinical trial outputs. Lack of appropriate trainings has been …
Tigabu Kasie Ayele, Emile Franc Doungmo Goufo, Stella Mugisha
Tuberculosis (TB) is a transmittable bacterial infection, and it is one of the main health problems worldwide. This infection is preventable and can be cured with an appropriate treatment. The mathematical modeling technique could be applied successfully to investigate the transm…
Victoria Overbeck, Samantha Malatesta, Tara Carney, Bronwyn Myers, Charles Parry, et al.
…und The COVID-19 pandemic negatively impacted all levels of tuberculosis (TB) treatment services, including directly observed therapy (DOT) programs used to promote medication adherence. We compared the rate of adherence to DOT before and during the pandemic among observational r…
Kranti Garg
…effort to highlight anxiety and depression in patients with tuberculosis (TB).[1] However, the attempt is undermined by the limitation in the number of studies and its subgroup analysis. Anxiety and depression may be synonymous for a common man, but in scientific reviews, the res…
Win Pa Pa Thu, Fei Kean Loh, Ong C
<title>Extract</title> Tuberculosis (TB) treatment is not quick and fast. Currently, the World Health Organization (WHO) recommends either a 6–9 month standard TB treatment regime of isoniazid, rifampicin, pyrazinamide and ethambutol initially or the 4-month regime of rifapentine…
Benjamin Idoko Omede, Olumuyiwa James Peter, William Atokolo, Bolarinwa Bolaji, Tawakalt Abosede Ayoola
… of drug resistance has become a major obstacle in treating tuberculosis (TB), significantly contributing to the increasing disease burden. Therefore, it is essential to study the transmission dynamics of the disease, considering the factors that contribute to the strain’s impact…
Chih-Yu Liu, Rou-Tsern Chen, Chin‐Chung Shu, Shu‐Yung Lin
…se The standard short-course treatment for drug-susceptible tuberculosis (TB) is 6 months, but in certain cases, treatment duration may need to be extended. However, limited research has been conducted on the prevalence and factors associated with extended TB treatment. Methods A…
Ronald Opito, Keneth Kwenya, Mark Kizito, Susan Alwedo, Baker Bakashaba, et al.
Abstract Background Tuberculosis (TB) is the leading cause of death from a single infectious agent globally. An estimated 10 million people are newly diagnosed and 1.5 million die of the disease annually. Uganda is among the 30 high TB burdened countries, with Karamoja having a s…
Ann Schraufnagel, Rebecca Crowder, Peter Wambi, Suzan Nakasendwa, Alex Kityamuwesi, et al.
ABSTRACT Background Adolescents (ages 10-19) affected by tuberculosis (TB) face unique challenges to completing TB treatment, resulting in increased loss to follow-up and mortality as compared to younger children and older adults. Digital adherence technologies (DATs) may be a us…
Stephanie Palacios, Glenford Refre, Patricio Palmes, Ma. Cecilia Momville
… the efficacy and safety of a 4-month treatment regimen for tuberculosis have been reported in many countries. Our study evaluated the efficacy and safety of the newer 4-month treatment regimen relative to the traditional 6-month treatment regimen. We used review of literature to…