Showing 151–175 of 200 documents
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Nur Ain Mohd Asri, Keh Min Xuan, Rafeah Suppian, Mohd Nor Norazmi, Maryam Azlan, et al.
…ss this problem as well as the government's goal to produce vaccines that are high-quality, efficient, and secure following the guidelines established by the National Pharmaceutical Regulatory Agency (NPRA).
 Therefore, the development of TB mucosal vaccines over the past fe…
Gishnu Harikumar Parvathy, Dhananjay Bhandiwad, Lars Eggers, Linda von Borstel, Jochen Behrends, et al.
…edge regarding the sexually dimorphic immune response to TB vaccines, where no accepted correlates of protection are yet available. In this context, our goal was to explore how individual sex influences the protective effects of TB vaccines. For this purpose, we vaccinated female…
Julia M. Scordo, Tucker J. Piergallini, Nicole D Reuter, Colwyn A. Headley, Vida Hodara, et al.
…s, which account for one-third of deaths in this age group. Vaccines are a primary tool to combat infection, yet they are less effective in the elderly population. While many groups have aimed to address this problem by studying vaccine-induced peripheral blood responses in the e…
Mangalakumari Jeyanathan, Dominik Fritz, Sam Afkhami, Emilio Aguirre, Karen Howie, et al.
Background Adenovirus-vectored (Ad-vectored) vaccines are typically administered via i.m. injection to humans and are incapable of inducing respiratory mucosal immunity. However, aerosol delivery of Ad-vectored vaccines remains poorly characterized, and its ability to induce muco…
B. M. Ayoub, E. Ramadan, N. Ashoush, M. M. Tadros, M. S. Hendy, et al.
Diabetes mellitus (DM) is one of the major risk factors for COVID-19 complications as it is one of the chronic immune-compromising conditions especially if patients have uncontrolled diabetes, poor HbA1c and/or irregular blood glucose levels. Diabetic patients' mortality rates wi…
V. A. Kukarkina, А. А. Голубкова, A. S. Podymova, A. A. Kukarkina
The objective of the study is to assess the scope and timing of tuberculosis vaccination in children with perinatal exposure to HIV, to determine the effectiveness of vaccination by the scarsize and results of Mantoux test in 12 month safter vaccination. Subjects and methods . Do…
Aakash Pandey, Abigail B. Feuka, Melinda K. Cosgrove, Megan E. Moriarty, Anthony Duffiney, et al.
…r vaccination campaigns, and further research on increasing vaccines efficacy and uptake rate in free-ranging deer are important for disease management.
Oluwaseun Oluwatosin Taofeek, Solomon Osarumwense Alile, Evans Mauta Elcanah, Louis Odinakaose Ezediuno, Ifeoluwa Adeniyi George, et al.
…nce its optimization and informing development of future TB vaccines.
Ahyar Ahmad, Andriansjah Rukmana, Miski Aghnia Khairinisa, Dian Ayu Eka Pitaloka, Rosana Agus, et al.
…archers to look for more effective options, such as subunit vaccines. This condition requires the development of a more effective subunit vaccine to protect active TB in productive and adult ages. There is an urgent need for more effective vaccines, as the Bacillus Calmette-Guéri…
Jesús Cortes, Tamar Jaaziel Monteiro, Kleidi Monteiro, Jacqueline Monteiro, Ofélia Monteiro, et al.
Introduction Healthcare workers (HCWs) faced a heightened risk of SARS-CoV-2 infection compared to the general population. The BCG vaccine, used for over a century, is known to modulate immune responses to various pathogens, including the SARS-CoV-2. This study examines the assoc…
Maja Stošić, Marko Veljković
Background: Since the beginning of the pandemic, COVID-19 affected lot of tuberculosis (TB) cases globally. Co-infection can lead to severe acute illness with possibilities of amplification of mortality and chronic lung sequelae. There is lack of data on COVID-19 vaccination cove…
Mayu Iwai, Takashi Fukushima, Noriyuki Watanabe, Atsuhiko Ohta, Atsuko Watanabe, et al.
To the Editors: A 16-month-old girl was referred to our hospital with a recently enlarging chest wall tumor. She was not vulnerable to infection and neither she nor her family had contact with anyone diagnosed with tuberculosis. She had received a bacillus Calmette–Guérin (BCG) …
Allison Portnoy, Rebecca A. Clark, Chathika K. Weerasuriya, Christinah Mukandavire, Matthew Quaife, et al.
…tential financial risk protection from introducing novel TB vaccines, and how health and economic benefits would be distributed across income quintiles. Methods: We modelled the impact of introducing TB vaccines meeting the WHO preferred product characteristics in 105 LMICs. For …
Andrew D. Kerkhoff, Jake M. Pry, Mwiza Haambokoma, Noelle Le Tourneau, Sandra Simbeza, et al.
Abstract Background New tuberculosis (TB) vaccines for adults and adolescents are crucial for achieving global control targets, and several candidates may be ready for introduction within five years. We conducted a convergent mixed-methods study in Lusaka, Zambia, among community…
Mudit Kumar
…capacity, it will be beneficial to have a limited number of vaccines available for the more vulnerable population by the end of 2020 and for the rest of the global population by the end of 2021. Keywords: Coronavirus; COVID-19; SARS-CoV-2; vaccine development, DNA vaccine, RNA va…
Hira Tanvir, Rebecca A. Clark, Tom Sumner, Katherine C. Horton, Tomos O. Prŷs‐Jones, et al.
…ause of infectious disease death. Modelling predicts new TB vaccines may reduce global burden but rely on assumptions about vaccine efficacy by TB disease stage and TB natural history, which may be incorrect. We explored the sensitivity of estimates of the impact of new TB vaccin…
Kara Jensen
Over 3.3 million children are living with HIV, infected primarily by mother-to-child transmission (MTCT). Breast milk exposure of HIV accounts for up to 44% of MTCT events. Despite serious efforts to prevent vertical HIV transmission, infant testing is often delayed and access to…
Zhongkai SHI, MD, Jan Andersson, MD
Phase I, randomized, double blinded, Placebo-controlled, immunogenicity and dose-range finding study of AERAS-404 in Bacille Calmette-Guerin (BCG) healthy adult male and sterile females. This ia a Phase I, randomized, placebo-controlled, double-blind study in three groups of hea…
Naomi E. Aronson, MD, Merlin L. Robb, MD
The purpose of this research is to find out if a single dose of pre-travel vaccination with BCG can lessen tuberculosis (TB) infection by producing an immune response when given to adults traveling to countries with a high or moderate burden of TB. BCG will be compared with a pla…
Stephen Spector, MD, Amaran Moodley, M.D
…ine efficacy has prompted investigators to develop novel TB vaccines and to experiment with enhancing the immune response to the current BCG vaccine. Increasing data indicate that children with low vitamin D levels and specific genetic variants that lower functional levels of vi…
Nitya Krishnan, Miles Priestman, Iria Uhía, Natalie Charitakis, Izabella T. Glegola-Madejska, et al.
…tility of this model to measure the effectiveness of two TB vaccines: the currently licenced BCG and a novel subunit vaccine candidate. To assess the efficacy of the skin challenge model a pharmacometric model was built describing the decline of fluorescence over time. The result…
Michaela Theilmann, Pascal Geldsetzer, Till Bärnighausen, Nikkil Sudharsanan
Abstract The Bacillus Calmette–Guérin (BCG) vaccine for tuberculosis (TB) is widely used globally. Many high-income countries discontinued nationwide vaccination policies as the TB prevalence decreased. However, there is continued interest in whether the general childhood immunit…
Ali Ali Velayati
…ases and their complications. One of the most controversial vaccines for its therapeutic effect on COVID-19 is the BCG vaccine. The BCG vaccine has been used worldwide since 1921. The first BCG strain was introduced in 1947, but mass production and nationwide prescribing began in…
GS Shepelkova, Vasiliy Reshetnikov, VG Avdienko, DV Shevyrev, VV Yeremeev, et al.
…aimed to compare the capabilities of three variants of mRNA vaccines encoding Esat6 epitopes of stimulating adaptive immune response formation in C57BL/6 mice (ELISpot, delayed hypersensitivity, IgG titers), as well as of protecting I/St mice against M. tuberculosis infection. Ef…
Jinhee Lee, DVM, PhD, Jae Chol Choi, MD, PhD, Youngmok Park, MD, PhD, Kwang Joo Park, MD, PhD, Jinsoo Min, MD, PhD
The purpose of this study is to evaluate the safety and explore the immunogenicity of ID93+GLA-SE compared to placebo following three intramuscular (IM) injections on Days 0, 28 and 56 in the Bacillus Calmette-Guérin (BCG)-vaccinated older adults aged 55 to 74 with negative or po…