Showing 151–175 of 200 documents
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Hojoon Sohn, Lekha Puri, Thi Ngoc Anh Nguyen, Anna H. van’t Hoog, Thi Van Anh Nguyen, et al.
…low to meet the 2035 end TB targets. Use of rapid molecular diagnostics that can be deployed in peripheral settings has the potential to address gaps in TB care cascade, improve case detection, and ultimately limit the on-going transmission of the disease. Methods: We assessed th…
Paul Paul, Rajput, Singh, Bera
Mycobacterium tuberculosis is the primary causative agent in the progression of TB, which is the leading cause of mortality in every region of the globe. On the other hand, it is not impossible for it to influence other regions of the body, such as the spine, the kidneys, the bra…
Derek C. Johnson, Kimberly Rodriguez, Diana Gómez-López, Darío Rodriguez, Diana Dávila, et al.
…ontext and can successfully be integrated into basic clinic diagnostics. The added testing capacity improved diagnostic and management capacity of the clinic, especially regarding asymptomatic STIs, and thus improved quality of care for key populations. A translated version of th…
MBBS, MD, Navakumar Manickam
Cutaneous tuberculosis (CTB) is a rare form of extrapulmonary tuberculosis, accounting for less than 2% of all TB cases. Its atypical presentations, which deviate from the classical forms like lupus vulgaris and tuberculosis verrucosa cutis, pose significant diagnostic challenges…
Jacobus De Waard, PhD
Determine the diagnostic accuracy for pulmonary tuberculosis in adults of the E-Nose in Venezuela. Acronyms: Tuberculosis (TB) Receiver Operating Curve (ROC) Common Terminology Criteria for Adverse Effects (CTCAE) The aim of the study is to determine the diagnostic utility of …
Muhammad Danasabe Isah, Muhammad Makusidi
…sistant strain. Intriguingly, the conventional tuberculosis diagnostics though time consuming and inefficient, its use still predominates in high disease burden settings. Meanwhile, the slow transition to use of advanced tuberculosis diagnostic methods seems to have an economic u…
Arunagiri Pandiyan
INTRODUCTION: According to WHO global tuberculosis report 2018, Worldwide, TB is one of the top 10 causes of death and the leading cause from a single infectious agent (above HIV/AIDS). False-negative results and misdiagnosis of TB suspects are common in developing nations, as mo…
Conor O’Halloran, Paul Burr, Danièlle Gunn‐Moore, Jayne C. Hope
The domestic dog (Canis lupus familiaris) is a competent host for Mycobacterium (M.) bovis infection but no ante-mortem diagnostic tests have been fully validated for this species. The aim of this study was to compare the performance of ante-mortem diagnostic tests across samples…
Eskild Petersen, David S.C. Hui, Jean B. Nachega, Francine Ntoumi, Delia Goletti, et al.
…ortant precedent for increasing access to affordable drugs, diagnostics and vaccines for other epidemic diseases affecting resource-poor countries. In April, 2021, a Brazil judge suspended drug patent extensions, a preliminary decision that could lower costs for drugs critical to…
Chendi Bih Hycenta, Vanessa Mwebaza Muwanga, Tracey Jooste, Martin Kidd, Simon C. Mendelsohn, et al.
<h3>Background</h3> Several host blood transcriptomic signatures have shown promise as tuberculosis (TB) diagnostic candidates, supporting the use of such biomarkers in prototype RNA-based point-of-care tests. Further validation of these signatures across different clinical and e…
Mona Mlika, Mohamed Majdi Zorgati, Mehdi Abdennadher, Imen Bouassida, Faouzi El Mezni, et al.
Background The diagnosis of lung cancer is based on the microscopic exam of tissue or liquid. During the recent decade, many biomarkers have been pointed to have a potential diagnostic role. These biomarkers may be assessed in blood, pleural effusion or sputum and they could avoi…
Wendbenedo Yasmine Astrid Sana, Tani Sagna, Ina Marie Angèle Traore, Absatou Ky Ba, Fatou Gueye Tall, et al.
Introduction: Burkina Faso, a West African country, has also seen a resurgence in new cases of tuberculosis. It would be useful to have an overview of how prevalence and diagnostic methods have changed in recent years. The aim of this study was to estimate the prevalence of tuber…
OJHA SAURABH GHANSHYAM -, PULKIT GUPTA -, Ved Prakash, Anil Maurya -, Shubham Tiwari
Abstract: CONTEXT: Tuberculosis (TB) remains endemic in India. Little local data have been reported on bronchoscopic evaluation of sputum‑negative pulmonary TB patients, which poses a significant diagnostic and therapeutic challenge. AIMS: To determine the diagnostic value of bro…
Huanqing Xiong, Huiqin Wang, Jiaying Gao, Shihong Zhao, Yujuan Li, et al.
Abstract Background : The Interferon-gamma release assay (IGRA) and Genechip are new tuberculosis diagnostic methods, but there have been limited studies conducted on combined application in tuberculosis. Starting in January 2021, Tangdu Hospital of Air Force Medical University b…
Alyssa Sales, Hien Thi Thu Le, Seke Muzazu, Evelyn Muleba Kunda‐Ng'andu, María del Mar Castro, et al.
Abstract Millions of tuberculosis (TB) cases are estimated to be undiagnosed and unreported annually. Sputum has been the primary approach for diagnostic testing but tongue swabs are being investigated as an alternative to expand testing. To understand potential uptake and implem…
A. Sivaprakasam, V. Gangadharan, G. Karthiga, P. Anandeswari
Background: Spontaneous sputum smear gave negative results in clinically and radiologically suspected pulmonary tuberculosis (TB) patients. Hence, the study aimed to evaluate the diagnostic yield of induced sputum with direct smear, concentrated smear, liquid culture, and GeneXpe…
Navya Krishna Naidu, Nagaraj Kondagunta, Visweswara Rao Guthi
Abstract Background: India has the highest tuberculosis (TB) burden in the world and account for nearly one-fourth of the global burden of TB. Although the Indian government provides a basic national health service, an increasingly large number of health-care interactions in Indi…
Lifan Zhang, Lidan Zhao, Yuchen Liu, Xiaochun Shi, Xiaoqing Liu
Abstract Background Systemic Lupus Erythematosus (SLE), an autoimmune disease, involves multiple immune dysfunctions. The progression of M.tb infection is closely related to the host's immune status. Abnormal immune functions increase the risk of active tuberculosis (ATB), partic…
Levern Africa, Michaile G. Anthony, Asanda Mfawze, Asikhangele Mtshabe, Marilyn Mentoor, et al.
…ulmonary tuberculosis (PTB). At enrolment, collection of TB diagnostics samples included respiratory samples (gastric aspirate, induced sputum and expectorated sputum), blood, urine and stool. Questionnaires on the acceptability and feasibility were collected from caregivers and …
Thiru Kumaran, S Gheena, R. Gayatri Devi
… was to assess the popular perception about the advances in diagnostics of HIV among the general population. An online survey with a self-structured questionnaire was prepared based on the advances in diagnostics of HIV/AIDS. A questionnaire containing 10 questions was distribute…
So Yun Lim, Jin-Yeong Kim, Sung Hee Park, Jiwon Jung, Min Jae Kim, et al.
Abstract Background There are limited data in real clinical practice on the diagnostic value of BAL (bronchoalveolar lavage) fluid galactomannan (GM) assay in patients with suspected invasive pulmonary aspergillosis (IPA) who had negative serum GM results. Methods This study was …
DR. RAJNI CHOUDHARY
INTRODUCTION: Tuberculosis (TB) caused by Mycobacterium tuberculosis is a global health concern. According to Global TB Report 2021, the incidence of tuberculosis was 19,33,381. Late diagnosis and delay in treatment causes increase in mortality and morbidity. A reliable and rapid…
Tamer A. Addissouky
…Short conclusion A multifaceted approach combining advanced diagnostics, optimized therapeutics, and strategic prevention is essential for addressing the global ITB burden. Future research should focus on developing point-of-care diagnostics, personalized treatment protocols, and…
D. Ashley Hill
…agnostic decision-making tree. A multimodal approach to bTB diagnostics, utilizing histopathology, culture, and PCR in parallel, was beneficial in identifying and correcting discrepant results for both cattle and feral swine submissions. Eurasian wild boar descendants from Texas …
Syed MA Zaidi, Anna K. Coussens, James A. Seddon, Tamara Kredo, Digby F. Warner, et al.
Abstract Background There is growing recognition that tuberculosis (TB) infection and disease exists as a spectrum of states beyond the current binary classification of latent and active TB. Our aim was to systematically map and synthesize published conceptual frameworks for diff…