Showing 126–150 of 200 documents
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Zhao,Jinyun, Mao,Weifang, Jin,Faxiang, Xu,Wenfang
…rug resistance patterns, mutation profiles in Mycobacterium tuberculosis isolates and clinical characteristics of tuberculosis patients in Shaoxing, Zhejiang, China.Methods: Clinical specimens and data from tuberculosis patients admitted in 2024 were collected. Cultures were esta…
L.D. Todoriko, V.I. Petrenko, О.С. Шевченко, S.B. Noreіko, Ihor Semianiv, et al.
…molecular genetic aspects of the formation of resistance in tuberculosis patients to avoid it during use of modern treatment programs. Objective — to assess the situation with the evolution of resistance of Mycobacteria tuberculosis and the stages of drug resistance development u…
Valeriu Crudu, Alexandru Codreanu, Sofia Alexandru, Valentina Vilc, Ana Donica, et al.
Tuberculosis, one of the ancient infections that especially affects humans, the main target organ of this disease being the lung, is caused by M. tuberculosis and remains one of the most important public health problems, especially in developing countries. The emergence of multid…
Ambuj Kumar Kushwaha, Abhisheka Bansal, Gunjan Arora, Divya Kushwaha
Tuberculosis (TB) and malaria remain two of the most formidable infectious diseases, continuing to exert a disproportionate toll on global health despite decades of scientific and medical advances. Pathogenic Mycobacterium species are responsible for major human diseases such as …
Siddharth G. Chatterjee
Background: India has largest population of drug resistant tuberculosis, the treatment of which is long and full of adverse drug reactions. Despite the ongoing research in clinical and pharmacological aspects, quality of life in drug-resistant tuberculosis remains less explored. …
Misnarliah, Andi Ernawati
Tuberculosis is still a global health problem. Prolonged treatment of tuberculosis and using several anti-tuberculosis drugs (OAT) can cause side effects, one of which is multidrug resistance. Cases of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium s…
Muhammad Sibte Hasan Mahmood
Multidrug-resistant tuberculosis (MDR-TB) is among the most troubling component of the pandemic of anti-microbial resistance since TB patients that fail treatment have a high peril of death. Extensively drug-resistant tuberculosis (XDR-TB) has emerged as a major public health pro…
Justin Ginting, Katharina Ellen Dominika, Ardo Sanjaya, Julia Windi Gunadi
Mycobacterium tuberculosis is a pathogen that causes the infectious disease tuberculosis. Based on its resistance, tuberculosis can be divided into Drug-susceptible Tuberculosis (DS-TB) and Drug-resistant Tuberculosis (DR-TB). MDR-TB is one type of DR-TB when M. tuberculosis comp…
Putri Bungsu Machmud, Dwi Gayatri, Sudarto Ronoatmodjo
BACKGROUND: Tuberculosis and its resistance are a major global health problem in the world. The increased incidence and mortality of tuberculosis in Indonesia remain a big public health issue especially in Jakarta Province. No published studies have focused on assessing the outco…
Aimen Ali
Tuberculosis is a worldwide public health problem that affects people from all walks of life, including those in the United States, where it is more frequent among immunocompromised patients and other high-risk groups. Tuberculosis is a disease that can be active or latent. Postp…
St George's Healthcare NHS Trust
Drug resistant tuberculosis is a growing problem world wide. The current methods for diagnosis are time consuming and may delay diagnosis and treatment for many weeks. In this study the investigators wish to take sputum samples from patients to see if the investigators can valida…
Mohammad Yasir Essar, Arash Nemat, Shoaib Ahmad, Ahsan Zil‐E‐Ali, Roy Rillera Marzo, et al.
…ith a huge burden of respiratory health diseases, including tuberculosis [1].According to the Global Tuberculosis report, Afghanistan is one of the countries with the highest incidence of tuberculosis in the WHO Eastern Mediterranean Region (EMRO).There are an estimated annual 13…
О.С. Шевченко, О.О. Pohorielova
Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problems in the world. That’s why the purpose of our study was to investigate the dynamics of the incidence of multidrug-resistant and extensively drug-resistant tuberc…
Cheng Ding, Wang,Shuting, Shangguan,Yanwan, Feng,Xuewen, Guo,Wanru, et al.
…Correspondence: Kaijin Xu Email zdyxyxkj@zju.edu.cnPurpose: Tuberculosis remains a major public health problem globally, especially in undeveloped countries. This study aimed to evaluate and review the long-term epidemic trends of tuberculosis in China.Methods: Data were extracte…
S. N. Alyushin, Alena Skrahina, Maryna Dziusmikeyeva, Varvara Solodovnikova, Aliaksandr Skrahin
The mortality rate among tuberculosis patients requiring intensive care is high. The development of severe conditions in patients with tuberculosis may be associated with the course of the underlying disease and with concomitant pathology. The aim of this work was to study the ri…
Vinayak Talwar, Abhishek Sadasivan
Sir, Tuberculosis (TB) is a preventable and curable infectious disease caused by the bacteria Mycobacterium tuberculosis. It affects the lungs but can also spread to other parts of the body. TB is transmitted through the air when an infected person coughs, sneezes or speaks. The …
RAFIK I. BAYRAMOV, J.M. Ismaitzada, İrada Akhundova, R.M. Abuzarav, Mehriban Seyfaddinova
…this purpose, 62 patients with<br> drug-resistant pulmonary tuberculosis were examined: bacterioscopic and bacteriological sputum exami-<br> nation, X-ray and CT examinations of the chest, Diaskintest, and to detect susceptibility to anti-tuberculosis<br> drug sputum examination …
Mohammed Solayman Hossain, Hoonhee Seo, Md Abdur Rahim, Md Sarower Hossen Shuvo, Indrajeet Barman, et al.
Tuberculosis (TB) remains a global health crisis, with the emergence of multidrugresistant strains necessitating the development of novel therapeutic strategies.Approximately one-fourth of the world's population, or 2 billion people, are infected with latent TB.The rise of multid…
Neil Sharma, Manish Singhal, Rachana Agrawal, Manoj Kumar Sharma, Sona Goyal
Context: Tuberculosis is a major health problem in India .Accurate and also fast diagnosis of tuberculosis has remained a challenge and we determined the impact of CBNAAT on notification of tuberculosis cases in Rajasthan. Aims: The Aim of the present Study was use of CBNAAT in t…
Mandeep Singh, Nikhil Gupta, Rajendra Prasad
Multidrug resistant tuberculosis (MDR-TB) has been an area of growing concern and is posing a threat to the control of tuberculosis (TB). The exact magnitude of problem of resistance to anti-tuberculosis drugs worldwide was not known till the 1994-97 global project on anti-tuberc…
Natalie J.E. Waller, Chen‐Yi Cheung, Gregory M. Cook, Matthew B. McNeil
…he increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished the efficacy of almost all available antibiotics, complicating efforts to combat the spread of this global health burden. Alongside the development of new drugs, optimised drug combinations ar…
Pankaj Jorwal, Anivita Aggarwal, Parul Kodan, Nitin Gupta, Sudeshna Ghosh, et al.
Dear Editor, Extensively drug-resistant tuberculosis (XDR-TB) is defined as a strain of Mycobacterium tuberculosis that is resistant to isoniazid, rifampicin, any one of the fluoroquinolones and any one of the aminoglycosides.[1] Although nomograms for predicting drug resistant t…
Pascal Lapierre, Joseph Shea, Shannon G. Murphy, Carol Smith, Donna Kohlerschmidt, et al.
Tuberculosis has been a bane of humanity for centuries and, still to this day, is estimated to affect more than two billion people worldwide (CDCGlobal, 2024). The slow growth rate of Mycobacterium tuberculosis (MTB) is a major challenge for timely diagnosis and appropriate treat…
N. A. Sosova, T. A. Zadremaylova, Н. М. Коновалова, A. V. Abramchenko, M. I. Romanova, et al.
…ctive: to compare treatment effectiveness of drug resistant tuberculosis (MDR, pre-XDR, XDR) depending on the HIV status of patients in Stavropol Region from 2019 to 2022. Subjects and Methods . In a retrospective study, chemotherapy outcomes for pulmonary tuberculosis (TB) were …
Aisha Alnami
Tuberculosis (TB) is a bacterial infection responsible for more than 1.5 million deaths per year. The emergence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) poses an urgent need for novel antituberculosis drugs. Filamentous temperature-sensitive p…