Showing 101–125 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Yang Liu, Yuanyuan Zhang, Ning Yao, Zhiyong Zhang, Qing Wang, et al.
…ment information as well as the vaccination records of live vaccines. Two stool samples were collected for virus detection and the vaccine-derived poliovirus was analyzed. A total of 26 primary immunodeficiency patients were enrolled among 3312 monitored cases, including 5 cases …
Joann Diray‐Arce, Asimenia Angelidou, Kristoffer Jarlov Jensen, Maria Giulia Conti, Rachel S. Kelly, et al.
Summary Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology, including metabolomics, enables new characterization of vaccine mechanisms of action, these tools have yet to be applied to infants at high risk of infectio…
Ben Morton, MD. MPH, MBChB
…us disease and the body's response and can help develop new vaccines and treatments. The purpose of this study is to set up a human challenge model using BCG to understand how the body responds to this. If our human challenge model works well it may be used to help researchers de…
И В Фельдблюм, M. Yu. Devyatkov, M. Kh. Alyeva
Relevance Hepatitis B and tuberculosis are a serious global health problem. Babies under one are at high risk of a severe form of these diseases and mortality. Immunization of newborns plays a key role both in the individual prevention of hepatitis B and tuberculosis and in reduc…
Shuihua Lu
There are four populations in Recombinant Mycobacterium tuberculosis Vaccine Freeze-dried (AEC/BC02) phase I clinical research. The clinical study adopt open research design. Population I have 25 subjects who received Tuberculin purified protein derivative(TB-PPD) skin test and …
И В Фельдблюм, M. Yu. Devyatkov, M. Kh. Alyeva
Relevance Hepatitis B and tuberculosis are a serious global health problem. Babies under one are at high risk of a severe form of these diseases and mortality. Immunization of newborns plays a key role both in the individual prevention of hepatitis B and tuberculosis and in reduc…
Tingting Li, K. J. Zhu, Yujie Kuang, Hongbo Qu, Zhang Qi, et al.
Abstract Background: Tuberculin skin test (TST) has been the most commonly used test for diagnosis of tuberculosis (TB) infection in China for many years, because of well-established algorithms for test interpretation and a good cost-effectiveness. To our knowledge , there is no …
Ramón A. Juste, Mariví Geijó, Natalia Elguezábal, Iker A. Sevilla, Marta Alonso‐Hearn, et al.
…ontrasting the literature, no deleterious effects of killed vaccines on females were observed. Mortality reduction would offset vaccination costs and could improve livestock systems efficiency and potentially reduce antibiotic use. Clinical trial registered with Spanish Agency fo…
Tong Yu, ChenChao Zhang, Jun-Hong Xing, Tong Zhang, Zhiqiang Xu, et al.
…, the urgent development of innovative and efficacious mRNA vaccines is imperative. In our study, we synthesized six unique mRNA vaccine formulations: the Receptor Binding Domain (RBD) monomer vaccine, RBD dimer (2RBD) vaccine, RBD-Ferritin (RBD-Fe) vaccine, ubiquitin-modified wi…
Helen McShane, Professor
The purpose of this study is to: 1. Demonstrate the safety of a novel TB vaccine (ID93/GLA-SE) when given to both BCG-vaccinated and BCG-naïve volunteers. 2. Provide preliminary immunogenicity data of this novel TB vaccine (ID93/GLA-SE). This clinical trial will apply an aeroso…
Dr.V.Krishna Mohan, PhD
An Open-labelled, Phase I Clinical Trial to Assess the Safety, Reactogenicity, Tolerability, and Immunogenicity of MTBVAC in healthy Indian adult volunteers A total of 30 subjects with Quantiferon®-TB Gold Plus assay negative and ages 18 to 65 years will be enrolled in this trial…
Mustafa Aslan, İlke Özer Aslan, Öner Özdemır
Dear Editor, COVID-19 is a new type of respiratory infection and might lead to serious pneumonia causing acute respiratory distress syndrome (ARDS). Most people infected with SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) manifest as having asymptomatic or mild to m…
Zhou Xing, PhD, Fiona M Smaill, MD
The purpose of this Phase 1 study is to evaluate the safety and immune responses of a new tuberculosis vaccine, Ad5Ag85A, administered to healthy volunteers. 48 subjects will be recruited, 24 who have previously been vaccinated with BCG and 24 who have not received BCG vaccine. T…
Hadi Peeridogaheh, Roghayeh Teimourpour, Shahram Habibzadeh, Jafar Mohammadshahi, Aida Gholoobi, et al.
…ere first immunized with BCG and then administered with DNA vaccines. Methods: In order to evaluate the immunogenicity of three DNA constructs, the levels of several immunomodulatory cytokines were measured in vaccinated mice. Thirty female BALB/c mice were divided into the follo…
E. M. Bogorodskaya, I. V. Nozdrevatykh, E. L. Khristoforova, Evgeny Belilovskiy
…ty before and after mass immunization with anti-coronavirus vaccines. Materials & Methods. An analysis was made of the incidence of a new coronavirus infection COVID-19 among employees of the Moscow Research and Clinical Center for Tuberculosis Control during April 1, 2020–Se…
Roșie Woodroffe, Kelly Astley, Rose Barnecut, Peter N. M. Brotherton, Christl A. Donnelly, et al.
Abstract In the United Kingdom, the management of bovine tuberculosis (bTB) challenges the coexistence of people and wildlife. Control of this cattle disease is hindered by transmission of its causative agent, Mycobacterium bovis , between cattle and badgers Meles meles . Badger …
Kendra Brett, Melissa Severn
… general use, and it is one of the most widely administered vaccines. Nevertheless, there are still some questions with regards to the effectiveness of the BCG vaccine, particularly, the duration of the effect, and the ability to protect against pulmonary TB in adults. A global r…
Tosin Yetunde Senbadejo, Tajudeen Oladunni GANIYU, Elijah Kolawole Oladipo, Olugbenga Samson Onile
…ainst tuberculosis, hence the need to design more effective vaccines that will protect adults and immunocompromised patients. Methods and materials: Proteins used in this study were retrieved from the NCBI database. The tools used for the design of the vaccine include AntigenPro …
Mohammad Javad Nasiri, Denise Rossato Silva, Foad Rommasi, Mohammad Mahdi Zahmatkesh, Zohreh Tajabadi, et al.
…he following keywords were used: tuberculosis, vaccination, vaccines and PTLD. PubMed/MEDLINE and Embase were used as the search engine, focusing on English-language literature only. RESULTS: We identified 9 vaccines potentially useful in PTLD. Influenza, pneumococcal and anti-CO…
Rosie Woodroffe, Kelly Astley, Rose Barnecut, Christl Donnelly, Henry Grub, et al.
In the United Kingdom, the management of bovine tuberculosis (bTB) challenges the coexistence of people and wildlife. Control of this cattle disease is hindered by transmission of its causative agent, Mycobacterium bovis, between cattle and badgers Meles meles. Badger culling has…
Jongga Adiyaksa, Fithriyah Sjatha
…ce of Mycobacterium tuberculosis (MTB) remains. A number of vaccines proposed to cure and prevent tuberculosis (TB) infection are undergoing various stages of clinical trials. Although vaccine production is progressing, more attention is needed. A number of TB vaccines are curren…
David F. Ackart, Faye Lanni, Victoria Mitcham, G. Brooke Anderson, Michael A. Lyons, et al.
Introduction:To design a human papillomavirus (HPV) vaccination promotion campaign as a basis for introducing a national HPV vaccination programme in Kuwait, 20 Kuwaiti parents of children eligible for vaccination were individually interviewed on their health beliefs.Methods: Bas…
National Institute of Allergy and Infectious Diseases (NIAID)
A nonrandomized, open-label trial will be conducted with a total of 64 healthy male and non-pregnant females, ages 18-45 years. Participants in Group A will enroll 32 participants to receive 2x10\^6 colony- forming units CFU TICE(R) BCG vaccination on Day 1 and 4x10\^6 CFU challe…
M B Mouton, R M Horowitz, V M Limbert, L Bachnak, L A Morici, et al.
…ung infections. We hope to utilize this in developing novel vaccines for tuberculosis that target correlates of protection for lasting protection for all individuals. This abstract is funded by: NIH
Helen McShane
…erience with recombinant fowlpox viruses in Oxford Three FP vaccines encoding different malaria antigens have been used so far in clinical trials in Oxford, FP9 ME-TRAP, FP9 CS and FP9 PP. To date 87 doses of FP9 ME-TRAP have been given to 55 volunteers in Oxford using various re…