Showing 101–125 of 200 documents
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Ganesh Kumar Verma, Muniba Alim, Ramesh Chand, Vinay Verma, Himanshu Gupta
BACKGROUND: Tuberculous meningitis (TBM) remains a leading cause of morbidity and mortality in children, particularly in endemic regions. Early diagnosis is crucial for optimal outcomes, yet remains challenging due to nonspecific clinical presentations and limited diagnostic sens…
Jeremy Li, Charles Frenette, Vivian G. Loo
Abstract Background Accurate and rapid diagnosis of SARS-CoV-2 infection is essential to prevent nosocomial transmission. Patients with negative COVID-19 tests at admission may still be in the incubation phase during hospitalisation. False negative results can occur when patients…
Soumya Basu, Subhra Chakraborty
…peration, this article reviews the evolving landscape of TB diagnostics, from traditional methods like microscopy and culture to cutting-edge molecular techniques and biomarker-based approaches. We examined the benefits of efficient rapid results against potential trade-offs in a…
Andrine
…PD and TB/HIV co-morbidity. The test could both be used for diagnostics and disease progression tracking.<br/><br/>Methods: The study consists of three parts; a COPD study, IPF study and TB/HIV study. For the IPF study 32 urine samples (16 HC and 16 IPF), 11 lavages (6 HC and 5 I…
World Health Organization
This operational handbook provides practical guidance for implementing WHO policies and recommendations on rapid diagnostic technologies for tuberculosis (TB) and drug-resistant tuberculosis (DR-TB). The publication describes WHO-recommended diagnostic tests for the detection of …
С. А. Стерликов, Aleksandr Mikhailov
…t impact on the healthcare system, including the laboratory diagnostics system. It is advisable to assess the current state of the tuberculosis laboratory diagnostics system to develop solutions for its optimization. Purpose: to analyze the state of organization (coverage and qua…
Anura David, Lyndel Singh, Pedro Da Silva, Keneilwe Peloakgosi-Shikwambani, Zanele Nsingwane, et al.
…Cobas assays as reliable alternatives for TB and resistance diagnostics, particularly in settings where rapid, accurate detection of MTBC and RIF or INH resistance is crucial. Importance The study demonstrates high diagnostic accuracy of the Cobas® MTB and MTB/RIF-INH assays, on …
Tiffeney Mann, Rishi K Gupta, Byron W P Reeve, Gcobisa Ndlangalavu, Aneesh Chandran, et al.
Abstract Background Undiagnosed tuberculosis (TB) remains a major threat for people living with HIV (PLHIV). Multiple blood transcriptomic biomarkers have shown promise for TB diagnosis. We sought to evaluate their diagnostic accuracy and clinical utility for systematic pre-antir…
Amy Faugno, Alexandra Y Laidman, Jonathan D Perez Martinez, Anita J Campbell, Christopher C. Blyth
…scribing. This study investigates the impact of these rapid diagnostics on the timeliness of effective and optimal antibiotic prescribing in paediatric patients with bacteraemia. METHODS: A single centre retrospective cohort study was performed comparing paediatric bacteraemia ca…
Anchu R Nath, Nayanabai Shabadi, И. М. Сон, P V Manirsha
…andardized diagnostic algorithms, and integrating molecular diagnostics are essential to improve patient care. A multidisciplinary and collaborative approach is recommended to overcome existing barriers.
Seyed Shahabedin Mohammad Makki, Fariba Ghorbani, Katayoun Najafizadeh, Shadi Shafaghi, Hamid Reza Khoddami Vishteh
Introduction: Although several studies have shown the relationship between tuberculosis (TB) and anthracosis, few studies have investigated the diagnostic value of various methods of diagnosis of TB in these patients. Objectives: This study was conducted to investigate the diagno…
E. Yu. Nosova, M. A. Sviridenko, Anastasia Khakhalina, Ksenia Galkina, Yu. D. Mikhailova, et al.
…8 patients (including HIV-infected ones) requiring rapid TB diagnostics. The study was conducted from one portion of the sediment of the diagnostic sample using bacteriological methods (luminescent microscopy, cultivation on Middlebrook 7H9 medium in the Bactec MGIT 960 system an…
Lancaster, Kathryn
…tensified (concentrated AFB smear and tuberculosis culture) diagnostics and followed for 8 weeks. The primary endpoint was appropriate treatment (i.e. antituberculosis therapy for those with tuberculosis, no antituberculous therapy for those without tuberculosis). Results: Sevent…
Victor Næstholt Dahl, Andreas Fløe, Frauke Rudolf, Jakko van Ingen, Aase Bengaard Andersen, et al.
BACKGROUND: Clinical characteristics of patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) in Denmark are undescribed. This study investigated clinical characteristics and diagnostic practices in patients with pulmonary NTM isolates. METHODS: Patients in Centra…
Adam Penn‐Nicholson, Sophia B. Georghiou, Nelly Ciobanu, Mubin Kazi, Manpreet Bhalla, et al.
Abstract Background The WHO End TB Strategy requires universal drug susceptibility testing and treatment of all people with tuberculosis. However, available second-line diagnostic tools are cumbersome and require sophisticated laboratory infrastructure, and ultimately less than h…
Carlos Mejía-Chew, Lauren Yaeger, Kevin Montes, Thomas C. Bailey, Margaret A. Olsen
Abstract Background Health care administrative database research frequently uses standard medical codes to identify diagnoses or procedures. The aim of this review was to establish the diagnostic accuracy of codes used in administrative data research to identify nontuberculous my…
George McNally, Danielle Solomon, Stephen Morris‐Jones, Santino Capocci, Matt Brown, et al.
<h3>Background</h3> Diagnostic confirmation of TB disease is central to high-quality TB care. It ensures that patients receive the correct treatment, (for TB and conditions that may be mistaken for it) and also allows drug susceptibility testing. However, in 2021 only 61% of TB d…
Víctor Roca Campañá, Rosa Eugenia Jiménez Paneque, Hector Silva
Objectives: To assess the diagnostic utility of clinical features in the major diagnostic categories of Fever of unknown origin (FUO).Methods: One hundred and thirty-three patients meeting the classic criteria of FUO were included in the study. A structured diagnostic protocol wa…
Jee Whang Kim, Hemu Patel, Richard Halliwell, Raman Verma, RC Free, et al.
<h3>Introduction</h3> Use of rapid molecular diagnostics such as Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert-Ultra) is endorsed by World Health Organization for rapid diagnosis of TB. Xpert-Ultra has improved sensitivity, but utility in low TB-prevalent settings, where paucibaci…
Kinari Shah, Talemwa Nalugwa, Danaida Marcelo, Robinah Nakawunde, Trang Trinh, et al.
Abstract Background Recognizing new and improved diagnostics as a key step to reducing the global tuberculosis (TB) burden, the World Health Organization (WHO) publishes target product profiles (TPPs) to guide development of novel TB diagnostics; however, TPPs have not included t…
Naohisa Urabe, Makiko Takeichi, Susumu Sakamoto, Nozomi Tokita, Keiya Watanabe, et al.
BACKGROUND: Accurate diagnosis of Nontuberculous mycobacterial pulmonary disease (NTM-PD) depends on the quality of sputum specimens. While assessing sputum purulence may enhance diagnostic accuracy in NTM-PD, its utility has yet to be fully established. METHODS: This single-cent…
Mari Miki, Keisuke Miki, Eri Akiba, Hiroyuki Kagawa, Yohei Oshitani, et al.
BACKGROUND: Measurement of exhaled nitric oxide (FeNO) is a potentially useful diagnostic test for asthma. However, no study has explored the relationship between FeNO and respiratory symptoms of nontuberculous mycobacterial pulmonary disease (NTM-PD) complicated with asthma. The…
Elinor B. Fajer, Fernanda Dockhorn Costa, Daniele Maria Pelissari, Fredi Alexander Díaz-Quijano, Artemir Coelho de Brito, et al.
…, but their access to World Health Organization recommended diagnostics is poorly understood. Methods We conducted a retrospective cross-sectional study of newly diagnosed TB cases in Brazil’s notifiable disease registry, which includes information on diagnostic tests performed, …
Ajithkumar Ittaman, Junais Koleri, Moideenkutty Gurukkal, Hamad Abdel Hadi, Muna Maslamani, et al.
Abstract Background Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a valuable diagnostic tool for mediastinal lymphadenopathy, particularly in cases of sputum-negative tuberculosis (TB). This retrospective study evaluates the diagnosti…
Nora Engel
This chapter examines attempts to innovate TB diagnostics for the point of care, aimed at improving diagnosing in resource-constrained settings and cutting diagnostic delays. Drawing on ongoing and past fieldwork from global to local levels, the analysis contrasts challenges of e…